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Cefoperazone induced hypersensitivity vasculitis  [cached]
Katiyar Subodh,Prakash Shivesh
Indian Journal of Dermatology , 2009,
Abstract: Cefoperazone has been reported to cause vasculitic complications only once before. Here, we report yet another case of hypersensitivity vasculitis associated with cefoperazone. A 28-year-old lady with pneumococcal pneumonia developed hypersensitivity vasculitis on the fifth day of cefoperazone therapy. Hypersensitivity vasculitis resolved gradually after removal of the agent and did not recur. Although hypersensitivity vasculitis has multiple causes, coexistence of hypersensitivity vasculitis and cefoperazone treatment, and the quick resolution of the disease after removal of the drug, strongly favors a causative relationship. To our knowledge, this is the second report of a hypersensitivity vasculitis associated with cefoperazone and hence the drug should be considered as a possible cause while evaluating a case of drug induced hypersensitivity vasculitis.
Hypersensitivity vasculitis induced by streptococcus pneumoniae  [cached]
Inamadar Arun,Sampagavi V
Indian Journal of Dermatology, Venereology and Leprology , 1994,
Abstract: A 10-year-old female child with pneumococcai meningitis complicated by hypersensitivity vasculitis presenting as purpuric and ecchymotic lesions is reported.
Cefoperazone / sulbacTam induced hyponatremia
Mitra Souvik,Basu Sujit
Indian Journal of Medical Sciences , 2006,
Comparison in a rat thigh abscess model of imipenem, meropenem and cefoperazone-sulbactam against Acinetobacter baumannii strains in terms of bactericidal efficacy and resistance selection
Kolayli Fetiye, Aynur Karadenizli, Erdem Okay, Sarpkaya Oz, Fatma Budak, Sibel Gundes, Haluk Vahaboglu
Annals of Clinical Microbiology and Antimicrobials , 2004, DOI: 10.1186/1476-0711-3-2
Abstract: A total of 18 strains were inoculated in 54 animals (one strain for three animals). Randomly selected 10 among these 18 strains were inoculated in another 10 rats as the control group. Imipenem, meropenem and cefoperazone-sulbactam were the antibiotics compared. After four days of treatment, Wistar albino rats (200 to 250 g) were sacrificed and the abscess materials were processed for mean colony counts and for the presence of resistant mutants.The mean CFUs per gram (mean ± (std. deviation) [×104]) of the abscess were: 9,14 (25,24), 2,11 (3,78), 1,20 (1,70) in the imipenem (n = 17), meropenem (n = 18) and cefoperazone-sulbactam (n = 17) groups, respectively. The differences were not significant. On the other hand, no resistant mutant was detected in abscess materials.This study indicated; first, cefoperazone-sulbactam is comparable to carbapenems in bactericidal efficacy in this particular abscess model and second, emergence of resistance due to spontaneous mutations is not at least a frequent phenomenon among A. baumannii.Acinetobacter species are associated with fatal infections in hospitals, particularly in intensive care units [1]. Severe underlying conditions like head trauma or head surgery that cause gross aspiration are major risk factors for Acinetobacter infections [2,3]. The relation between Acinetobacter spp and an ominous outcome do not, however, solely depend on the fact that the members of this genus tend to cause infections in patients with severe underlying conditions. Another determining feature is these bacteria often appear as multiply resistant to antibiotics [4].Multiple resistance in Acinetobacter is believed -in most instances- to be related to the abnormal expression of chromosomally encoded, inherited mechanisms, like porins, penicillin bounding proteins and chromosomal beta-lactamases [5-8].Resistance to beta-lactams due to altered intrinsic mechanisms is not unique to Acinetobacter. Down regulated porins co-operate with over expressed ch
Hypersensitivity Vasculitis with Leukocytoclastic Vasculitis Associated with Alpha-1-Proteinase Inhibitor
Nicola W. Mwirigi,Charles F. Thomas Jr.
Case Reports in Medicine , 2009, DOI: 10.1155/2009/941258
Abstract: Prolastin is a commercially available form of alpha-1-antitrypsin (AAT) that is derived from pooled human plasma and used for treatment of severe alpha-1-antitrypsin deficiency (AATD). We describe a patient with AATD who developed presumed hypersensitivity vasculitis (HV) following a Prolastin infusion. Hypersensitivity vasculitis (HV), or cutaneous vasculitis, is characterized by inflammation of the small vessels of the skin with resultant ischemia to the distally supplied areas. To our knowledge, this is the first reported case of presumed hypersensitivity vasculitis following Prolastin infusion.
Comparison of in vitro activities of ceftazidime, piperacillin-tazobactam, and cefoperazone-sulbactam, and the implication on empirical therapy in patients with cancer  [cached]
Prabhash K,Medhekar A,Biswas S,Kurkure P
Indian Journal of Cancer , 2009,
Abstract: Background: Infection is a common cause of morbidity and mortality in cancer patients. In most of these cases empirical treatment is provided because the focus of infection is not identified. Empiric antibiotics provided to these patients are based on isolates, sensitivity, and on guidelines. Here we have compared three antibiotics recommended as empirical treatment by the Infectious Disease Society of America (IDSA). Aims: To compare the three antibiotic sensitivities for gram negative isolates at our institute. Objective: To choose the optimal antibiotic as the empirical treatment for cancer patients developing infections. Materials and Methods: We collected the data on isolates and antibiotic sensitivity patterns of isolates for ceftazidime, piperacillin + tazobactum, and cefoperazone from the medical oncology department. We subsequently compared the sensitivity of these three antibiotics. Statistical Methods: The isolates were mapped using the WHONET 5.4 software. The analysis was conducted using SPSS 15.0 for Windows. McNemar Chi-square test was used to compare the sensitivity percentages between any two antibiotics. The agreement between the antibiotic and the gold standard was calculated using the Kappa statistic. Two tailed p values were reported. Results: The results showed that there was a difference among sensitivities for these antibiotics. It appears that the sensitivity of ceftazidime was inferior to the two other antibiotics. Also cefoperazone has better sensitivity as compared to piperacillin + tazobactum. Conclusion: In spite of these three antibiotics being recommended by IDSA our data suggest that it should not be followed blindly and local sensitivity data is important for formulating institutional guidelines for using antibiotics.
Simultaneous Determination of Sulbactam Sodium and Cefoperazone Sodium in Sulperazon by High Performance Liquid Chromatography

LI Fa-sheng,XU Zhi-xiu,XIAO Hong-bin,LIANG Xin-mian,

色谱 , 2000,
Abstract: A reversed-phase, isocratic high performance liquid chromatographic method with acid mobile phase can separate sulbactam and cafoperazone within 12 minutes. Column packed with Hypersil ODS2(250 mm x 4.6 mm i.d., 5 microns) was manufactured by Dalian Elite Company. Mobile phase is composed of water (adjusted to pH 4.0 with 1% phosphoric acid) and acetonitrile (80:20, V/V). The detection was performed at 210 nm and the injection volume was 2 microL. Cefoperazone and sulbactam have good linearity in the ranges of 100 mg/L to 800 mg/L and 100 mg/L to 1,000 mg/L with the correlation coefficients of 0.9991 and 0.9997 respectively. This method is easily to be operated and can be applied for manufacturing and medicinal study.
Drug Induced Hypersensitivity and the HLA Complex  [PDF]
Ana Alfirevic,Munir Pirmohamed
Pharmaceuticals , 2011, DOI: 10.3390/ph4010069
Abstract: Drug-induced hypersensitivity reactions are of major concern and present a burden for national healthcare systems due to their often severe nature, high rate of hospital admissions and high mortality. They manifest with a wide range of symptoms and signs, and can be initiated by a wide range of structurally diverse chemical compounds. The pathophysiological mechanisms underlying hypersensitivity reactions are not well understood, but it is thought that they are immune mediated. MHC region on Chromosome 6 contains many genes with immune function. Classical MHC molecules are highly polymorphic cell surface glycoproteins whose function is to present peptide antigens to T cells. In addition to conferring protection from some diseases, HLA alleles are also associated with an increased risk of other diseases, including drug-induced hypersensitivity. Pharmacogenetic approach to predict the risk of drug-induced hypersensitivity has been established for several drugs. We will discuss the progress of hypersensitivity pharmacogenetics over the last few years and focus on current efforts of the international community to develop consortia which aim to standardize disease phenotypes and to identify affected individuals through international collaborations. In addition, we will discuss the clinical utility of HLA typing as predictive or diagnostic testing for drug-induced hypersensitivity.
Severe leukocytoclastic vasculitis secondary to the use of a naproxen and requiring amputation: a case report
Keri Brown, Jeanine Martin, Susan Zito
Journal of Medical Case Reports , 2010, DOI: 10.1186/1752-1947-4-204
Abstract: We present the case of a 33-year-old African American woman with below the knee and bilateral digital gangrene from hypersensitivity vasculitis secondary to the non-steroidal anti-inflammatory medication naproxen.This is an original case report focusing on the rheumatologic management of leukocytoclastic vasculitis. However, other specialties, such as internal medicine, dermatology, infectious disease, general surgery and pathology, can gain valuable information by reviewing this case report. Reporting a case of leukocytoclastic vasculitis secondary to treatment with naproxen will advance our understanding of this disease etiology by adding yet another non-steroidal anti-inflammatory drug to the list of potential causes of leukocytoclastic vasculitis.The term leukocytoclastic vasculitis (LCV) has been used interchangeably with other descriptions of small-vessel vasculitides, including drug-induced vasculitis, allergic vasculitis, hypersensitivity angiitis, and hypersensitivity vasculitis (HSV) [1]. Leucocytoclastic angiitis is an isolated condition without systemic vasculitis or glomerulonephritis [2,3]. The American College of Rheumatology (ACR) has developed criteria for the classification of hypersensitivy vasculitis [4,1]. When used diagnostically the positive predictive value of these criteria is only ~30% [1]. In addition, other limitations include the lack of differentiation of hypersensitivity vasculitis from Henoch-Sch?nlein purpura (HSP) [1]. Michel et al. proposed a different classification methodology using the same database of patients with vasculitis as that used for the ACR criteria to differentiate HSV from HSP [1]. Using this classification, the presence of three or more of these criteria (see Additional File 1), has a sensitivity of 71% and a specificity of 84% for the diagnosis of HSV [1].The inflammation of small blood vessels, most commonly postcapillary venules, is the cardinal histologic feature of LCV [1]. Other characteristic features includ
Propylthiouracil-induced lupus-like or vasculitis syndrome
Cuneyt Tetikkurt, Mehmet Yuruyen, Seza Tetikkurt, Nihal Bayar, Imran Ozdemir
Multidisciplinary Respiratory Medicine , 2012, DOI: 10.1186/2049-6958-7-14
Abstract: This is a case of PTU induced-autoimmune disease in whom the accurate distinction between drug-induced-lupus (DIL) and vasculitis was not possible due to the significant overlap of clinical and laboratory findings causing a significant diagnostic challenge for the chest physician.
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