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Gene frequencies of ABO and Rh(D) blood group alleles in Lagos, South-West Nigeria
OA Iyiola, OO Igunnugbemi, OG Bello
Egyptian Journal of Medical Human Genetics , 2012,
Abstract: Background: It has been well documented that the ABO and Rhesus remain clinically the most significant blood group systems. There is limited information on the gene frequency of the ABO and Rhesus blood groups from Lagos, South-West Nigeria. Data from this study will be of immense use to the geneticists, biologists, blood transfusion services policy maker and clinicians. Aim of this study: This study aims to provide descriptive information on the genetic composition and variation of population in Lagos State, Nigeria, with respect to blood group and Rhesus factor contributing to the existing knowledge. Subjects and methods: This study investigated the gene frequencies for the ABO and Rh(D) alleles in a population consisting of different ages in Lagos, Nigeria, over a period spanning 12 years (1998–2009). The 23,832 and 23,764 individuals were typed for ABO and Rh blood groups, respectively. We analyzed the genotypic and allelic frequencies based on Hardy–Weinberg equations. Chi-square goodness-of-fit statistic was calculated to compare observed and expected frequencies and to investigate heterogeneity between years. Results: 5504 (23.1%), 5072 (21.3%), 647 (2.7%) and 12,609 (52.9%) were blood groups A, B, AB and O, respectively. Over the period of this study, we observed an overall trend of ABO blood group was O> B > A> AB in both males and females. We also observed that blood group O was the most encountered phenotype while group AB was the least phenotype encountered among the studied population in both genders. This distribution differs significantly (p<0.05) from those expected under the Hardy–Weinberg law. With regard to the Rh blood group, individuals with Rh positive (DD and Dd) were 0.69 and 0.28. Rh negative (dd) was 0.03. This also showed that Rh(D) positive was the most phenotype observed in this study. This distribution do not differ significantly (p>0.05) from those expected under the Hardy–Weinberg law. Conclusion: Our results demonstrate that there exist genetic variability and polymorphism as regards ABO and Rh blood group among the population sampled. These findings would be useful to geneticists and clinicians when planning to address future health challenges relating blood transfusion and marriage counseling.
Prevalence and gene frequencies of A1A2BO and Rh(D) blood group alleles among some Muslim populations of North India
R Hussain, M Fareed, A Shah, M Afzal
Egyptian Journal of Medical Human Genetics , 2013,
Abstract: Background: Research on ABO group system has been of immense interest, due to its medical importance in different diseases. Till date only a few studies have been done on the prevalence and gene frequencies of A1A2BO and Rh(D) blood groups among the Muslim populations of Uttar Pradesh, North India. The data generated in the present work may be useful for health planners while making efforts to face the future health challenges in the region. Aim: This study was conducted to determine the prevalence and gene frequencies of A1A2BO and Rh(D) blood groups among six Muslim populations of Aligarh district, Uttar Pradesh, North India. Subjects and methods: Blood samples from a total of 724 healthy, unrelated individuals were drawn at random from the six different endogamous groups of Muslim populations of Uttar Pradesh, North India. A1A2BO and Rh blood grouping were carried out by standard slide agglutination method and allele frequencies were determined. Results: In total 724 samples analyzed, the most frequent blood group was found to be group O 29.97% (n= 217), followed by A1 26.52% (n=192), B 20.03% (n= 145), A1B 19.34% (n= 140), A2 2.90% (n= 21) and A2B 1.24% (n= 9). The overall phenotypic frequencies of A1A2BO blood groups were O >A1>B> A1B>A2>A2B. The calculated allelic frequencies were 0.5619, 0.2214, 0.1973 and 0.0259 for group Io, Ib, Ia1 and Ia2, respectively. The Chi-square differences for A1A2BO blood groups among different Muslim populations were found to be significant (v2 =41.22, df= 25, p <0.02). Out of total 724 samples, 613 (84.67%) samples were Rh+ve and 111 (15.33%) were Rhve.
Frequencies of ABO Gene and Rh Blood Groups in Hamadan, Iran  [cached]
Hamid Pour-Jafari,Morteza Hashemzadeh Chaleshtari,Mohammad Reza Imani
Journal of Research in Health Sciences , 2011,
Abstract: Background: Determining of gene frequencies of A, Band 0 genes from ABO blood group system and D and d genes from Rhesus system are objectives of the present study. Methods: The study was a cross sectional descriptive study. All the voluntary blood donors, 7361 people, attending to the Hamadan, Iran, Blood Bank during 1996 were studied. Primary information from the sex of blood donors and their results of ABO & Rh blood types were obtained from the official records of Hamadan Blood Bank. Then the frequencies of genes A, B, 0 of ABO system and D and d genes of Rhesus system were calculated. The final results were compared with each other according to their sex. Results: In ABO system, the most frequent blood types were 0, A, Band AB, respectively. Conclusion: The frequent alleles were 0, A, B, respectively. The frequency of AB type in women was about twice than the men. About 92% of subjects were Rh positive.
Modeling the effect of age at calving × breed group of dam's interaction on weaning weight of Charolais-Zebu crossbred calves
Toral, Fábio Luiz Buranelo;Torres Júnior, Roberto Augusto de Almeida;Lopes, Paulo Sávio;Silva, Luiz Otávio Campos da;Reis Filho, Jo?o Cruz;
Revista Brasileira de Zootecnia , 2010, DOI: 10.1590/S1516-35982010000500015
Abstract: the objective of this study was to evaluate alternatives for modeling the interaction between age of dam at calving (aod) and the dam genetic group (dgg) on the weaning weight (w225) of charolais-zebu (ch-z) crossbred calves. data from 56,965 crossbred calves were analyzed by the least square method. regression coefficients for age of dam at calving were estimated nested into each class of the dam genetic group (cla model); for age of dam at calving × dam charolais percentage (age of dam at calving × fch) and age of dam at calving × dam heterozygosity (age of dam at calving × fh) (fchfh model); for age of dam at calving × dam charolais percentage (fch model); for age of dam at calving × fh (fh model); or only for age of dam at calving (nint model). segmented polynomials were used to model the general shape of the age of dam at calving effect and its interaction with dam genetic group. the knots were at 6.33 and 10.66 years of age of dam at calving and general linear and quadratic coefficient regression and specific quadratic coefficient regression after each knot were fitted. the regression coefficients were estimated nested within sex of the calf in all situations. according to the f test for sum of squared residuals differences, the inclusion of the age of dam at calving × fh interaction did not improve the fit of the model and the cla model provided the best fit. however, the estimates of the age of dam at calving and dam genetic group interaction from the cla model for dam genetic group × sex of the calf classes with few records were not appropriate, but the estimates of the age of dam at calving and dam genetic group interaction from the fch model for those classes were appropriate. the differences were small in the estimates of the age of dam of calving and dam genetic group interaction from the cla or fch models for dam genetic group × sex of the calf classes with many records.
Onchocerciasis and ABO Blood Group Status: A Field Based Study
K.N. Opara
International Journal of Tropical Medicine , 2012,
Abstract: The distribution of ABO blood group was investigated among onchocerciasis patients in Agbokim, a rural community within the Cross River basin Nigeria. A total of 398 individuals comprising 224 clinically and parasitologically confirmed onchocerciasis patients and 174 apparently healthy age-matched individuals (control) were used for this study. Frequencies of the blood groups were 62.06% for blood group O, A (17.84%); B (16.58%) and AB (3. 52%). The gene frequencies were, O (0.621), A (0.178), B (0.166) and AB (0.035), while the allelic frequencies were P = 0.11, q = 0.10 and r = 0.79. There was a significant (p< 0.05) association between ABO blood group system and onchocerciasis infection with blood group O subjects being more susceptible to infection than the other blood groups. The possible exploitation of this association in the production of candidate vaccine and/or potent drug against the adult worm is discussed.
Tipificación de tres marcadores genéticos de caracteres de importancia comercial en ganado Charolais: implicaciones en la ganadería para carne en México
Parra-Bracamonte,Gaspar M; Sifuentes-Rincón,Ana M; Arellano-Vera,Williams; Almanza-González,Alberto; De la Rosa-Reyna,Xochitl F;
Revista Colombiana de Ciencias Pecuarias , 2009,
Abstract: samples from registered charolais sire candidate bulls for breeding herds and managed in a performance test station (n=130) were analyzed in order to estimate genotypic and allelic frequencies of three single nucleotide polymorphisms associated to beef quality traits. two calpain gene snp markers, capn316 and capn4751, and the charolais private mutation q204x associated to double-muscling phenotype, were assessed. high frequency of normal allele was observed in capn316 (f=0.85) and similar frequencies for normal and favorable alleles in capn4751 (f=0.58 and 0.42, respectively). for q204x, a low prevalence for the double muscling promoter allele was observed (f=0.03) attributable to negative selection criterion over this trait in the last 30 years. implication and validation effects of the marker effects on the beef production system are discussed. implementation of marker assisted management could help system development, support creation of quality meat niches and facilitate the increasing profitability for current beef production industry.
k-Casein, b-lactoglobulin and growth hormone allele frequencies and genetic distances in Nelore, Gyr, Guzerá, Caracu, Charolais, Canchim and Santa Gertrudis cattle
Kemenes, Paola Augusta;Regitano, Luciana Correia de Almeida;Rosa, Artur Jord?o de Magalh?es;Packer, Irineu Umberto;Razook, Alexander George;Figueiredo, Leopoldo Andrade de;Silva, Nirlei Aparecida;Etchegaray, Maria Ant?nia L.;Coutinho, Luiz Lehmann;
Genetics and Molecular Biology , 1999, DOI: 10.1590/S1415-47571999000400012
Abstract: the genotypes for k-casein (k-cn), b-lactoglobulin (b-lg) and growth hormone (gh) were determined by polymerase chain reaction (pcr) and restriction enzyme digestion in seven breeds of cattle (nelore, gyr, guzerá, caracu, charolais, canchim and santa gertrudis). k-casein had two alleles with the a allele occurring at a higher frequency in bos indicus breeds (0.93, 0.92 and 0.91% for gyr, guzerá and nelore, respectively). the b-lactoglobulin locus had two alleles in all of the breeds. european breeds had a higher frequency of the b-lg a allele than zebu breeds. the gh locus had two alleles (l and v) in bos taurus and was monomorphic (l allele only) in all of the bos indicus breeds evaluated. the highest frequency for the v allele was observed in charolais cattle. the markers used revealed a considerable similarity among breeds, with two main groups being discernible. one group consisted of zebu and santa gertrudis breeds and the other consisted of european and canchim breeds.
k-Casein, b-lactoglobulin and growth hormone allele frequencies and genetic distances in Nelore, Gyr, Guzerá, Caracu, Charolais, Canchim and Santa Gertrudis cattle  [cached]
Kemenes Paola Augusta,Regitano Luciana Correia de Almeida,Rosa Artur Jord?o de Magalh?es,Packer Irineu Umberto
Genetics and Molecular Biology , 1999,
Abstract: The genotypes for k-casein (k-CN), b-lactoglobulin (b-LG) and growth hormone (GH) were determined by polymerase chain reaction (PCR) and restriction enzyme digestion in seven breeds of cattle (Nelore, Gyr, Guzerá, Caracu, Charolais, Canchim and Santa Gertrudis). k-Casein had two alleles with the A allele occurring at a higher frequency in Bos indicus breeds (0.93, 0.92 and 0.91% for Gyr, Guzerá and Nelore, respectively). The b-lactoglobulin locus had two alleles in all of the breeds. European breeds had a higher frequency of the b-LG A allele than Zebu breeds. The GH locus had two alleles (L and V) in Bos taurus and was monomorphic (L allele only) in all of the Bos indicus breeds evaluated. The highest frequency for the V allele was observed in Charolais cattle. The markers used revealed a considerable similarity among breeds, with two main groups being discernible. One group consisted of Zebu and Santa Gertrudis breeds and the other consisted of European and Canchim breeds.
Distribution of ABO, Rh, MNSs, Kell and Duffy blood-group antigens in population of Vojvodina  [PDF]
Vojvodi? Svetlana
Medicinski Pregled , 2003, DOI: 10.2298/mpns0304173v
Abstract: Introduction Analysis of erythrocyte blood group antigen polymorphisms and genetic variability in population of Vojvodina was performed by investigating gene and genotype frequencies which determine antigens of ABO, Rh, MNSs, Kell and Duffy blood-group systems. Material and methods We investigated 350 unrelated persons from Vojvodina in regard to appurtenance of ABO, Rh, MNSs, Kell and Duffy blood-group systems. We calculated gene, genotype, phenotype frequencies and proportion significance test. Results and discussion Results of investigation revealed that gene and genotype frequencies of investigated blood-group systems are similar to corresponding data for majority of European populations, while statistically significant differences were established in inhabitants of geographically distant regions. Values of proportion significance test revealed statistically significant differences of genotype frequencies for ABO and MNSs blood-group antigens in populations of: Australian Aborigines, Chinese population, Arabians, Blacks, Eskimos, American Indians (Navaho and Pueblo) and population of Papua New Guinea. Statistically significant differences of genotype frequencies were established in inhabitants of narrow geographical areas of Europe such as: Finland, Germany, Sweden, Albania, England and Netherlands. Conclusion Our results point to the fact that erythrocyte blood-groups have different frequencies in some parts of the world, and that there are great differences in frequencies of some blood-groups among inhabitants of various continents and races. Genetical peculiarity of the population of Vojvodina points to the fact that differences in blood-group frequencies are also present among inhabitants of narrow geographical areas.
The history of the Diego blood group
Junqueira, Pedro C.;Castilho, Lilian;
Revista Brasileira de Hematologia e Hemoterapia , 2002, DOI: 10.1590/S1516-84842002000100004
Abstract: diego blood group initially, because it appeared to be rare, was considered as a family or 'private factor'. with further investigation, it was possible to trace this blood group from an individual family in venezuela to the indians across the continent of america and eventually to the mongolian race in asia. this review article follows the developments over the years and the history of the diego blood group.
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