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Evaluation of Antagonism of Penicillium TS67 Against Soybean Root Rot Disease and Corn Southern Leaf Blight
青霉TS67菌株对大豆根腐病和玉米小斑病的防治效果评价

WANG Xi,WANG Su-Ying,GAO Peng-Hui,
王 霞
,王素英,高朋辉

微生物学通报 , 2008,
Abstract: Through pot experiments, the disease index and control efficiency of TS67 cell, the fermentation liquid of TS67 and the supernatant of TS67 separately act on Fusarium oxysporum and Bipolaris maydis was detected. Experiment results analysis with SPSS statistical analysis software indicated all treatments of TS67 could inhibit both of soybean root rot disease and corn southern leaf blight (P<0.01). Using dressing seeding with the mixture of TS67 cell and Fusarium oxysporum on soybean, the maximum control efficiency of soybean root rot disease (63.98%) was obtained. Spraying the fermentation liquid of TS67 before infecting corn southern leaf blight, the maximum control efficiency of corn southern leaf blight (53.34%) was obtained. Furthermore, experiment results indicated that dressing seeding with TS67 on soybean promoted soybean seeding growth.
萝卜溶菌酶抑菌效果的初步研究  [PDF]
华南农业大学学报 , 1997,
Abstract: 研究了萝卜溶菌酶对白色葡萄球菌,金黄色葡萄球菌,枯草杆等3种革兰氏阳性基本国策和变形菌、大肠杆菌,鼠伤寒沙门氏杆菌,多杀巴斯德氏杆菌,雏白痢沙门氏菌,产气杆菌等6种革兰氏阴性菌及酿酒酵母,总状毛霉,黑根霉、黑曲霉、青霉等5种真菌的抑制效果,同时还研究了萝卜溶菌酶对白菜软腐病菌,柑橘溃疡病菌,番茄青枯病菌,水稻细条病菌,水稻白叶枯病菌及烟草青枯病菌等6种植物病原细菌的抑菌效果。实验证明:萝卜溶菌酶
黑茶优势菌对绿茶浸提液发酵过程多酚类化合物的影响  [PDF]
黄秋桂,张灵枝,龚雪梅,杨伟琼,曾淑婷
食品科学 , 2014,
Abstract: ?利用从普洱茶中分离出的黑曲霉、根霉和从茯砖茶中分离出的冠突散囊菌接种云南大叶种晒青毛茶茶汤,进行单一菌株发酵,对发酵过程茶多酚类化合物的含量变化进行分析。结果表明:随着发酵时间的延长,茶多酚含量显著降低,黄酮类化合物总量在黑曲霉、冠突散囊菌作用下分别减少72%、31.76%,在根霉作用下增加了94.92%;儿茶素各组分的含量变化较大,其中表没食子儿茶素、表没食子儿茶素没食子酸酯、表儿茶素、表儿茶素没食子酸酯均呈现显著的下降趋势,而儿茶素、没食子酸在不同菌株作用下表现出不同的变化规律;茶黄素在黑曲霉、根霉作用下先增加后减少,冠突散囊菌则相反;茶红素总体呈下降趋向,茶褐素在根霉、冠突散囊菌作用下显著增加。
Bioactive Metabolites Produced by Fungi Cultures  [PDF]
L. M. Levy,G. M. Cabrera,Jorge E. Wright,A. M. Seldes
Molecules , 2000, DOI: 10.3390/50300354
Abstract: A screening of metabolites guided by antimicrobial and citotoxic bioassays was conducted with several fungi. The bioactive compounds were isolated and identified from the active extracts.
Hypolipidemic effect of the bioactive extract from Morchella conica
尖顶羊肚菌活性提取物降血脂作用的研究

YIN Wei-Wei,ZHANG Song,WU Jin-Feng,
殷伟伟
,张松,吴金凤

菌物学报 , 2009,
Abstract: 尖顶羊肚菌是一种珍贵、稀有的食药用真菌.研究表明,尖顶羊肚菌具有增强肌体免疫力、抗疲劳、抗病毒、抗氧化、抑制肿瘤等作用(Elmastas etal.2006:孙晓明等2001;余群力1997).然而关于尖顶羊肚菌活性提取物降血脂的研究尚不多见.
Production of Bioactive Secondary Metabolites by Marine Vibrionaceae  [PDF]
Maria Mansson,Lone Gram,Thomas O. Larsen
Marine Drugs , 2011, DOI: 10.3390/md9091440
Abstract: Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to produce bioactive secondary metabolites and studies have been limited to only a few species. Most of the compounds isolated from vibrios so far are non-ribosomal peptides or hybrids thereof, with examples of N-containing compounds produced independent of nonribosomal peptide synthetases (NRPS). Though covering a limited chemical space, vibrios produce compounds with attractive biological activities, including antibacterial, anticancer, and antivirulence activities. This review highlights some of the most interesting structures from this group of bacteria. Many compounds found in vibrios have also been isolated from other distantly related bacteria. This cosmopolitan occurrence of metabolites indicates a high incidence of horizontal gene transfer, which raises interesting questions concerning the ecological function of some of these molecules. This account underlines the pending potential for exploring new bacterial sources of bioactive compounds and the challenges related to their investigation.
Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites  [PDF]
Samuel Abbas,Michelle Kelly,John Bowling,James Sims,Amanda Waters,Mark Hamann
Marine Drugs , 2011, DOI: 10.3390/md9112423
Abstract: Porifera have long been a reservoir for the discovery of bioactive compounds and drug discovery. Most research in the area has focused on sponges from tropical and temperate waters, but more recently the focus has shifted to the less accessible colder waters of the Antarctic and, to a lesser extent, the Arctic. The Antarctic region in particular has been a more popular location for natural products discovery and has provided promising candidates for drug development. This article reviews groups of bioactive compounds that have been isolated and reported from the southern reaches of the Arctic Circle, surveys the known sponge diversity present in the Arctic waters, and details a recent sponge collection by our group in the Aleutian Islands, Alaska. The collection has yielded previously undescribed sponge species along with primary activity against opportunistic infectious diseases, malaria, and HCV. The discovery of new sponge species and bioactive crude extracts gives optimism for the isolation of new bioactive compounds from a relatively unexplored source.
Bioactive Metabolites from Spilanthes acmella Murr.  [PDF]
Supaluk Prachayasittikul,Saowapa Suphapong,Apilak Worachartcheewan,Ratana Lawung,Somsak Ruchirawat,Virapong Prachayasittikul
Molecules , 2009, DOI: 10.3390/molecules14020850
Abstract: Spilanthes acmella Murr. (Compositae) has been used as a traditional medicine for toothache, rheumatism and fever. Its extracts had been shown to exhibit vasorelaxant and antioxidant activities. Herein, its antimicrobial, antioxidant and cytotoxic activities were evaluated. Agar dilution method assays against 27 strains of microorganisms were performed. Results showed that fractions from the chloroform and methanol extracts inhibited the growth of many tested organisms, e.g. Corynebacterium diphtheriae NCTC 10356 with minimum inhibitory concentration (MIC) of 64-256 mg/mL and Bacillus subtilis ATCC 6633 with MIC of 128-256 mg/mL. The tested fractions all exhibited antioxidant properties in both DPPH and SOD assays. Potent radical scavenging activity was observed in the DPPH assay. No cytotoxic effects of the extracts against KB and HuCCA-1 cell lines were evident. Bioassay-guided isolation resulted in a diverse group of bioactive compounds such as phenolics [vanillic acid (2), trans-ferulic acid (5) and trans-isoferulic acid (6)], coumarin (scopoletin, 4) and triterpenoids like 3-acetylaleuritolic acid (1), b-sitostenone (3), stigmasterol and stigmasteryl-3-O-b-D-glucopyranosides, in addition to a mixture of stigmasteryl-and b-sitosteryl-3-O-b-D-glucopyranosides. The compounds 1–6 represent bioactive metabolites of S. acmella Murr. that were never previously reported. Our findings demonstrate for the first time the potential benefits of this medicinal plant as a rich source of high therapeutic value compounds for medicines, cosmetics, supplements and as a health food.
Bioactive metabolites from Trichoderma harzianum and Trichoderma longibrachiatum
P.K. Tarus, C.C. Lang’at-Thoruwa, A.W. Wanyonyi, S.C. Chhabra
Bulletin of the Chemical Society of Ethiopia , 2003,
Abstract: The tea plant, Camellia sinensis (L.) O. Kuntze is an important crop in the agriculturally based economy of Kenya. Many diseases affect the tea plant but the most prevalent is armillaria root rot caused by the fungus Armillaria mellea. Compounds from the fermentation of Trichoderma species in different media were bioassayed against some selected gram-positive and gram-negative bacteria, fungi including Armillaria mellea, a yeast and a Mucor. Compounds obtained from T. harzianum, and T. longibrachiatum when cultured in various media were investigated individually for in-vitro antifungal and antibacterial activities by agar diffusion technique. Some of the compounds produced definite antifungal and antibacterial activities. 2-Phenylethanol (1) and tyrosol (2) obtained from T. harzianum are reported for the first time from Trichoderma species. The most active metabolite isolated from these strains was 6-n-pentyl-α-pyrone (3), which showed the highest antifungal and antibacterial activity and completely inhibited the growth of Armillaria mellea fungus at a concentration of 200 ppm. Compound 4 (sorbicillin) exhibited moderate activity against the fungal test organisms. KEY WORDS: Trichoderma harzianum, Trichoderma longibrachiatum, 2-Phenylethanol, Tyrosol, 6-n-Pentyl- -pyrone, Armillaria Mellea Bull. Chem. Soc. Ethiop. 2003, 17(2), 185-190.
Research Trends: Bioactive Metabolites of Fungal Origin
A.K. Onifade
Research Journal of Biological Sciences , 2012,
Abstract: The need to combat human, agronomic and veterinary diseases or pests has sustained research interests directed at finding new medications from under-exploited biodiversity. The adoption of bioassay techniques, which correlate with prevention, inhibition and reversal of diseases or elimination of pests in screening natural products for bioactive compounds, is critical to the discovery of new medications. This study focuses on the chemistry and biological activity of fungal secondary metabolites that connect academia with industry. It discusses the technical skills needed to find biologically active compounds from fungi.
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