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Current advances in the application of proteomics in apoptosis research
LiShun Wang,GuoQiang Chen
Science China Life Sciences , 2011, DOI: 10.1007/s11427-010-4123-0
Abstract: Apoptosis, or programmed cell death, is a complex, genetically-determined process involved in the development and maintenance of homeostasis in multicellular organisms. Dysregulation of apoptosis has been implicated in a number of diseases, including cancer and autoimmune disease. Thus, the investigation of apoptotic regulation has evoked considerable interest. Many apoptotic proteins have been shown to be post-translationally modulated, such as by protein cleavage, translocation, protein-protein interaction, and various post-translational modifications, which fall precisely within the range of proteomic analysis. Recently, contemporary proteomic technologies have achieved significant advances and have accelerated research in functional and chemical proteomics, which have been applied to the field of apoptosis research and have the potential to be a driving force for the field. This review highlights some of the major achievements in the application of proteomics in apoptosis research and discusses new directions and challenges for the near future.
Application of differential proteomics in mechanism research of acupuncture  [cached]
Lin-na Yu
Zhong Xi Yi Jie He Xue Bao , 2011,
Abstract: Proteomics, a new branch of science, has been used to study protein expressions on the molecular level with a dynamic perspective. Organisms under varying states may express different proteins, which results in the set-up of differential proteomics. Research methods of differential proteomics include the separation and identification of proteins. Differential proteomics has a rapid development in recent years. In the study of acupuncture, researchers have reached certain achievements using differential proteomics to investigate the mechanisms of acupuncture treatment for some diseases, including acute spinal cord injury, ischemic cerebrovascular disease, Parkinson’s disease and neuralgia.
Application of Genomics/Proteomics Technologies in the Research of Biocompatibility of Biomaterials  [PDF]
L¨1 Xiao-Ying, HUANG Yan, YU Ya-Dong, YANG Ya-Min
无机材料学报 , 2013, DOI: 10.3724/sp.j.1077.2013.12269
Abstract: Biocompatibility is a key scientific issue in the research area of biomaterials. With the development of molecular biology techniques, the evaluation of biocompatibility of biomaterials has deepened from the animal level and cellular level to molecular level. The development of biomics technologies provide effective tools for high-throughput evaluating molecular biocompatibility on whole scale, and understanding the interaction mechanism between biomaterial and human body. In this paper, current research of biocompatibility and the application of biomics technologies in biocompatibility study of biomaterials were reviewed.
Advance of molecular marker application in the tobacco research
XZ Liu, HY Zhang
African Journal of Biotechnology , 2008,
Abstract: Tobacco (Nicotiana spp.) is one of the most important commercial crops in the world. During the last two decades, molecular markers have entered the scene of genetic improvement in different fields of agricultural research. The principles and characteristics of several molecular markers such as RFLP, RAPD, AFLP, microsatellites and minisatellites applied in tobacco genetics and breeding were reviewed. The application and development of molecular marker in tobacco genetic research was presented emphatically in the following areas: evolutionary genetics, population genetics and genotyping of cultivars, mapping and tagging of genes, and diversity analysis of germplasm. Finally, the perspective of molecular marker’s application in tobacco genetic breeding in the future was discussed.
Recent advance in research technique of plant membrane proteomics

ZHANG Jiang-wei,CHEN Shang-wu,MA Hui-qin,

中国生物工程杂志 , 2007,
Abstract: Plant membrane proteomics is one of the most active research fields in plant science.Proteomics is becoming an important content in the plant physiology.The preparation of plant membrane proteins and the methods of protein identification are reviewed.Furthermore,a review is given about the progress in plant membrane proteomics including plasma membrane,tonoplast and other membrane system.The database for the proteomics is introduced as well.Finally,the prospect of the plant membrane proteomics is raised for reference.
Proteomics in Pancreatic Cancer Research  [PDF]
Ruihui Geng,Zhaoshen Li,Shude Li,Jun Gao
International Journal of Proteomics , 2011, DOI: 10.1155/2011/365350
Abstract: Pancreatic cancer is a highly aggressive malignancy with a poor prognosis and deeply affects the life of people. Therefore, the earlier diagnosis and better treatments are urgently needed. In recent years, the proteomic technologies are well established and growing rapidly and have been widely applied in clinical applications, especially in pancreatic cancer research. In this paper, we attempt to discuss the development of current proteomic technologies and the application of proteomics to the field of pancreatic cancer research. This will explore the potential perspective in revealing pathogenesis, making the diagnosis earlier and treatment. 1. Introduction Pancreatic cancer is a highly aggressive malignancy with a poor prognosis; however, the present treatments are incapable of producing a desired effect. The patients generally die within six months after diagnosis, and the overall five-year survival rate is less than 5% [1]. Its incidence is increasing in China and other countries. Therefore, the earlier diagnosis and better treatments are urgently needed. In recent years, the development of quantitative proteomics technology has stimulated considerable interest in applying the technology for clinical applications, such as revealing pathogenesis, making the diagnosis earlier, and treatment. In this paper, we provide an overview of recent findings in proteomics of pancreatic cancer. 2. The Outline of Proteomics Research The term “proteome” was first used in 1994 and describes the entire set of proteins expressed by a given genome, cell, tissue, or organism [2]. Initially, the word proteomics referred to the techniques used to analyze a large number of proteins at the same time; however, at present this word covers any approach that yields information on the abundance, properties, interactions, activities, or structures of proteins in a sample. Proteomics is the main tool for proteome research. The rapid development of proteomics was made possible by the progress in analytical instrumentation, especially in mass spectrometry, and it is increasingly becoming the foundation in leading scientific workgroups and in clinical research labs. Current proteomics research can be defined as two types [3] (i) cell-mapping proteomics which aims to define protein-protein interactions to build a picture of the complex networks that constitute intracellular signaling pathways and (ii) protein expression proteomics and which monitors global expression of large numbers of proteins within a cell type or tissue and quantitatively identifies how patterns of expression
Research advance in application of RAPD techniques in entomology

HU Yanhong,CHI Defu,

应用生态学报 , 2004,
Abstract: This paper summarized the application of RAPD techniques in insect taxology and ecology,relative of species,systemic development,identification of pest,diagnosing for pest resistance,construction of molecular linkage map,and molecular assistant breeding.The problems existing in the applications of RAPD in entomology were indicated,and their countermeasures were given.It was mentioned that with the development of theories and experimental techniques,insect molecular biology would make new progress and conquer all those problems.
Research Advance on Mechanism and Application of HATs and HDACs in Epithelial-Mesenchymal Transition of Lung Cancer  [cached]
Rui CHANG,Jiacong YOU,Qinghua ZHOU
Chinese Journal of Lung Cancer , 2013, DOI: 10.3779/j.issn.1009-3419.2013.04.07
Abstract: Lung cancer is one of the most common diseases that endanger health and life of people domestically. A number of recurrence and death of lung cancer originated from metastasis. As a key step in metastasis of lung cancer, epithelial to mesenchymal transition involved down-regulation of E-cadherin, as well as regulated by EMT transcription factors. HATs and HDACs is a protein family that catalyzes acetylation and deacetylation of histones. Not only they have vital functions in tumor pathogenesis, but also participate in the EMT of lung cancer. HATs and HDACs interact with certain EMT transcription factors. Moreover, the function of these EMT transcription factors may be regulated by acetylation, which has influence on EMT program in lung cancer. Therefore, this review introduces the event of HATs and HDACs function in EMT of lung cancer, and investigate the molecular mechanism of their interaction. Then, the potential of HDAC inhibitor utilization in the inhibition of EMT and lung cancer therapy were discussed, as to pave the way for the related basic research and clinical practice.
Application of genomics and proteomics in study of traditional Chinese medicine  [cached]
Wen Jin-Kun
Zhong Xi Yi Jie He Xue Bao , 2004,
Abstract: The technique of genomics and proteomics is one of the fastest developments with the farest-reaching consequences in the high and new biotechnology in the world of today. It can be used to screen the target molecules of the action of traditional Chinese medicines, to identify the new effective components from traditional Chinese medicines,and to explore the mechanisms of the effects of traditional Chinese medicines. It meets the shortcomings of the conventional methodology being applied in the current studies of traditional Chinese medicine. Application of the theories and technique of genomics and proteomics in the study of traditional Chinese medicine would be of great significance for opening new research field of traditional Chinese medicine, for facilitating the integration of traditional Chinese medicine and modern biological science and technology, and for promoting the internationalization of traditional Chinese medicine.
Applications of proteomics in hepatic diseases research
Wei Sun,Fuchu He
Science China Life Sciences , 2004, DOI: 10.1360/03yc0014
Abstract: Proteomics has become an important part in the leading research area and been widely used in the disease-associated study. In hepatic research field, proteomics could be applied in study of hepatic diseases including liver cancer, cirrhosis and hepatotoxicities, etc. Significant proteins could be identified as biomarkers, drug targets and clues for pathogenesis illumination.
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