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Hybrid Clinical and Histopathological Pattern in Annular Lesions: An Overlap between Annular Elastolytic Giant Cell Granuloma and Granuloma Annulare?
Felipe Ladeira de Oliveira,Luisa Kelmer C rtes de Barros Silveira,Alice de Miranda Machado,José Augusto da Costa Nery
Case Reports in Dermatological Medicine , 2012, DOI: 10.1155/2012/102915
Abstract: Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unclear pathogenesis which belongs to the group of disorders in the skin and elastic fibers with similar clinical features of granuloma annulare (GA). This case report is intended to describe a rare hybrid pattern in histopathology demonstrating coexistence of AEGCG and GA. An endocrine disease, such as diabetes mellitus (DM), could contribute to the coexistence of both lesions, and this possibility must be included in the medical investigation.
Generalized Granuloma Annulare In An Actinic Distribution
Sandhu kamaldeep,Kumar A J
Indian Journal of Dermatology , 2004,
Abstract: Generalized granuloma annulare is an uncommon form. Lesions localized to sunexposed areas are rare. We herein report a case of actinically distributed generalized granuloma annulare in a diabetic female.
Subcutaneous granuloma annulare  [cached]
Dhar Sandipan,Kanwar Amrinder,Das Asim,Kaur Surinder
Indian Journal of Dermatology, Venereology and Leprology , 1994,
Abstract: Two cases of subcutaneos granuloma annulare are reported. Clinical presentation was in the form of hard subcutaneous nodules; histopathology confirmed the clinical diagnosis. The cases were unique because of onset in adult hood, occurrence over unusual sites and absence of classical lesions of granuloma annulare elsewhere.
Subcutaneous granuloma annulare  [cached]
Dhar Sandipan,Kanwar Amrinder,Das Asim,Kaur Surinder
Indian Journal of Dermatology, Venereology and Leprology , 1993,
Abstract: Two cases of subcutaneous granuloma annulare are reported. Clinical presentation was in the form of hard subcutaneous nodules, histopathology confirmed the clinical diagnosis. The cases were unique because of onset in adult age, occurrence over unusual sites and absence of classical lesions of granuloma annulare elsewhere.
Hybrid Clinical and Histopathological Pattern in Annular Lesions: An Overlap between Annular Elastolytic Giant Cell Granuloma and Granuloma Annulare?  [PDF]
Felipe Ladeira de Oliveira,Luisa Kelmer C?rtes de Barros Silveira,Alice de Miranda Machado,José Augusto da Costa Nery
Case Reports in Dermatological Medicine , 2012, DOI: 10.1155/2012/102915
Abstract: Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unclear pathogenesis which belongs to the group of disorders in the skin and elastic fibers with similar clinical features of granuloma annulare (GA). This case report is intended to describe a rare hybrid pattern in histopathology demonstrating coexistence of AEGCG and GA. An endocrine disease, such as diabetes mellitus (DM), could contribute to the coexistence of both lesions, and this possibility must be included in the medical investigation. 1. Introduction Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unclear pathogenesis whichbelongs to the group of disorders inthe skin andelastic fiberswith similarclinical featuresof granuloma annulare (GA) and necrobiosis lipoidica [1]. Lesions of AEGCG are mostly found in middle-aged white women, usually located on sun-exposed areas and rarely on covered areas [2]. Clinically, AEGCG presents as papules and annular plaques with erythematous bordersand withatrophichypopigmented center growingcentrifugally [3]. The chronic course of this disease is a typical feature as the variable response to existing treatments [4]. Therefore, this case report is intended to describe and discuss a case of AEGCG, irresponsive to the treatment, associated with diabetes and rare hybrid pattern in histopathology demonstrating coexistence of AEGCG and GA. 2. Case Presentation A 54-year-old man presented with a one-year complaint of asymptomatic and diffuse skin lesions increasing gradually in number and size. These lesions first appeared on his upper limbs. His occupation was a house builder and he didnot report to work without shirt. The man’s personal history included diabetes. According to the patient, the control of diabetes did not change the evolution of the skin lesions. There was no known family history of similar skin changes. Dermatological examination revealed asymmetric erythematous papules and atrophic plaques with slightly elevated border and annular configuration on the neck, trunk (Figure 1), arms, and forearms (Figure 2). There was no mucosal lesion or nails change. The initial differential diagnoses included GA and leprosy. Direct mycological examination and anti-HIVwere negative. Figure 1: Atrophic plaques with slightly elevated border. Observe the annular pattern. Figure 2: Detail of the erythematous annular lesion. On histological examination of a skin biopsy taken from one of the forearm lesions, there was fragmentation of elastic fibers in the giant cell (Figure 3(a)) and
Widespread Granuloma Annulare  [cached]
Jaswal R,Mittal R,Kanwar A J
Indian Journal of Dermatology , 1999,
Abstract: A widespread granuloma annulare in a 42 year old female is reported. The lesions were large and annular with sharply defined raised beaded margins and involved the trunk and upper extremities.
Granuloma annulare - Remission with puvasol  [cached]
Lakshmi Chembolli,Srinivas C
Indian Journal of Dermatology , 2010,
Abstract: A 64-year-old man with generalized papular granuloma annulare of four years duration with frequent relapses and remissions presented with persistent lesions while on 15 mg prednisolone and achieved complete remission with PUVASOL therapy using solarium.
Generalized granuloma annulare  [cached]
Khatri M,Shafi M,Sen N
Indian Journal of Dermatology, Venereology and Leprology , 1995,
Abstract: A 35-years-old female patient had generalized pruritic papular lesions, distributed like dermatitis herpetiformis for last 4 years. Histopathologic changes were typical of granuloma annulare with negative results of direct immunofluorescence. The patient did not have association of diabetes mellitus or any other systemic disease. She failed to respond to dapsone therapy and 13-cis-retinoic acid.
Generalized umbilicated granuloma annulare  [cached]
Chaudhary Ajay,Malkani Ram,Aswani Vijay
Indian Journal of Dermatology, Venereology and Leprology , 1998,
Abstract: Generalised umbilicated granuloma annulare is reported in an elderly man. There was no association of diabetes or other systemic disease.
Generalized granuloma annulare in a patient with myelocytic leukemia and chronic hepatitis B virus infection  [cached]
Askin Ulku,Durdu Murat,Senel Engin
Indian Journal of Dermatology, Venereology and Leprology , 2009,
Abstract: Granuloma annulare is a granulomatous disorder of the dermis and subcutaneous tissue, with different clinical types. Generalized granuloma annulare is a rarely encountered clinical entity. We describe a 60-year-old woman with a 4-month history of generalized annular lesions. She had a history of myelocytic leukemia and chronic hepatitis B virus infection. To date, both acute myelocytic leukemia and hepatitis B virus infection have been described independently in association with generalized granuloma annulare but have never been described together in association with generalized granuloma annulare. Probable etiological causes of granuloma annulare are discussed in our patient.
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