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Longitudinal Myelitis As The First Manifestation of Systemic Lupus Erythematosus
Ne?e ?ELEB?SOY,Feray GüLE?,Adem BAYRAK?I,Figen YARGUCU
Journal of Neurological Sciences , 2009,
Abstract: Acute longitudinal myelitis (ALM) as the initial manifestation of systemic lupus erythematosus (SLE) has been reported in just two cases. We herein present the third case associated with antiphospholipid antibodies with an unfavorable outcome. All patients with ALM should be tested for SLE and urgent treatment with intravenous pulse methylprednisolone and cyclophosphamide must be started. Alternative treatment trials must also be established as there are patients with permanent neurologic disability like ours despite appropriate therapy.
Periorbital edema as initial manifestation of chronic cutaneous lupus erythematosus
Samar Erras, Laila Benjilali, Lamiaa Essaadouni
Pan African Medical Journal , 2012,
Abstract: Periorbital edema occurs frequently in dermatomyositis, but it has rarely been noted in systemic systemic lupus erythematosus. We describe a patient who developed bilateral periorbital edema and erythema as the sole manifestation of systemic lupus erythematosus. Pan African Medical Journal 2012; 12:57
Chorea as the First and Only Manifestation of Systemic Lupus Erythematosus
Abdul Razzakh Poil,Fahmi Yousef Khan,Abdo Lutf,Mohammed Hammoudeh
Case Reports in Rheumatology , 2012, DOI: 10.1155/2012/907402
Abstract: We report a case of right-sided hemichorea associated with systemic lupus erythematosus (SLE) in a female patient who presented with involuntary movements of hand and foot, without any other manifestation of SLE. Further workup showed positive tests for antinuclear antibody, anti-Smith antibody, anti-dsDNA, and antiphospholipid antibody (aPL). The patient was started on aspirin and hydroxychloroquine and her chorea resolved after three weeks of followup. This is one of the few reported cases of SLE where chorea is presented as the first and only manifestation of SLE.
Lupus panniculitis as an initial manifestation of systemic lupus erythematosus
Patel Raksha,Marfatia Y
Indian Journal of Dermatology , 2010,
Abstract: In May, 2003, a 28-year-old female presented with large non-healing ulcers on face, trunk and limbs covered with black hemorrhagic crust. There were no other systemic manifestations. Diagnosis of lupus panniculitis was considered on clinical and histopathological grounds. The lesions healed completely, with scarring, with systemic corticosteroid, hydroxychloroquine and topical 2% mupirocin. She came again in November, 2005, with malar rash, joint pain, scarring alopecia of the scalp and albuminuria. Her ANA, AntidsDNA came positive and diagnosed as having systemic lupus erythematosus (SLE). She responded well to systemic corticosteroid, antimalarial and topical antibacterial. The evolution of lupus panniculitis is slow and characterized by regression of the inflammatory lesions when treated with antimalarial drugs. The lupus panniculitis generally has a favorable course.
Chorea as the First and Only Manifestation of Systemic Lupus Erythematosus  [PDF]
Abdul Razzakh Poil,Fahmi Yousef Khan,Abdo Lutf,Mohammed Hammoudeh
Case Reports in Rheumatology , 2012, DOI: 10.1155/2012/907402
Abstract: We report a case of right-sided hemichorea associated with systemic lupus erythematosus (SLE) in a female patient who presented with involuntary movements of hand and foot, without any other manifestation of SLE. Further workup showed positive tests for antinuclear antibody, anti-Smith antibody, anti-dsDNA, and antiphospholipid antibody (aPL). The patient was started on aspirin and hydroxychloroquine and her chorea resolved after three weeks of followup. This is one of the few reported cases of SLE where chorea is presented as the first and only manifestation of SLE. 1. Introduction Central nervous system (CNS) lupus is a serious but potentially treatable illness, which still presents a very difficult diagnostic challenge. The frequency of neuropsychiatric manifestations in SLE varies widely, depending on the type of manifestations and the method used for evaluation [1]. However, neurologic and psychiatric symptoms are reported to occur in 14 to 80 percent of patients either prior to the diagnosis of SLE, or during the course of their illness [2]. Chorea is a relatively uncommon manifestation of SLE; however, chorea as the first and sole manifestation of SLE is extremely rare [3]. In this paper, we present a young woman who presented with hemichorea as a first and sole manifestation of SLE. 2. Case Report A 27-year-old female presented to emergency room with involuntary movements of her right arm and leg. These movements had started 4 weeks earlier and gradually became worse, involving the right side of the body; she had difficulty in holding things with her right hand and difficulty in walking. There was no history of rash, photosensitivity, hair loss, oral ulcer, Raynaud's phenomenon, dryness of mouth or eyes, oral contraceptive intake, weight loss, headache, loss of consciousness, or seizure. She had no family history of rheumatic or neurological diseases and her past medical history was unremarkable. She denied smoking and alcohol consumption. The patient was multigravida, she had two children; both pregnancies were uneventful. Physical examination revealed choreic movements of her right hand and foot. They were jerky, purposeless, intermittent, and irregular movements. Examination of other systems was unremarkable. Initial investigations showed a normal complete blood count, blood chemistry, and liver function tests. Her coagulation profile was normal except for prolonged activated partial thromboplastin time (APTT) of 68.8 seconds (25?sec to 36.5 second). Antinuclear antibody (ANA) was 1?:?1280, and Anti-dsDNA was 70.5?IU (<25?IU) and anti-Smith
Cricoarytenoiditis as an Initial Manifestation of Systemic Lupus Erythematosus
Jean-Michel Hougardy,Nicolas Roper,Alain Michils,Muhammad S. Soyfoo
Case Reports in Rheumatology , 2011, DOI: 10.1155/2011/317379
Abstract: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease encompassing a broadened spectrum of clinical manifestations. Vocal cords involvement in SLE is not a frequent entity but can be life threatening if not treated. We hereby report the case of a patient presenting with cricoarytenoiditis and vocal cord dysfunction revealing SLE.
Pulmonary hemorrhage as a manifestation of systemic lupus erythematosus
Santos, Bruno Hollanda;Santos, Rodrigo Ribeiro;Santos, Celeide Fátima;Kakehasi, Adriana Maria;Von Tiesenhausen, Hermann Alexandre Vivacqua;
Revista do Hospital das Clínicas , 2004, DOI: 10.1590/S0041-87812004000100008
Abstract: the authors report a case of a 19-year-old woman admitted for the investigation of fever and hemolytic anemia for the previous 2 months. as an inpatient, she had convulsions and sudden loss of consciousness, developing hemoptysis, hypoxia, and respiratory insufficiency. examination showed pericardial effusions on the echocardiogram and bilateral alveolar condensations on the thoracic radiograph. a hypothetical diagnosis of systemic lupus erythematosus was made, and measurement of the antinuclear factor was requested along with daily pulse therapy methylprednisolone, in spite of which the outcome was fatal. afterwards, the result of the antinuclear factor test was positive, with a titer of 1:5120, showing a fine punctiform pattern, fulfilling the criteria for systemic lupus erythematosus according to the american college of rheumatology. secondary pulmonary hemorrhage in this connective tissue disease is an uncommon but serious complication that involves a high level of mortality in spite of intensive treatment, as is also reported in the literature.
Pulmonary hemorrhage as a manifestation of systemic lupus erythematosus  [cached]
Santos Bruno Hollanda,Santos Rodrigo Ribeiro,Santos Celeide Fátima,Kakehasi Adriana Maria
Revista do Hospital das Clínicas , 2004,
Abstract: The authors report a case of a 19-year-old woman admitted for the investigation of fever and hemolytic anemia for the previous 2 months. As an inpatient, she had convulsions and sudden loss of consciousness, developing hemoptysis, hypoxia, and respiratory insufficiency. Examination showed pericardial effusions on the echocardiogram and bilateral alveolar condensations on the thoracic radiograph. A hypothetical diagnosis of systemic lupus erythematosus was made, and measurement of the antinuclear factor was requested along with daily pulse therapy methylprednisolone, in spite of which the outcome was fatal. Afterwards, the result of the antinuclear factor test was positive, with a titer of 1:5120, showing a fine punctiform pattern, fulfilling the criteria for systemic lupus erythematosus according to the American College of Rheumatology. Secondary pulmonary hemorrhage in this connective tissue disease is an uncommon but serious complication that involves a high level of mortality in spite of intensive treatment, as is also reported in the literature.
Reporte de un caso de pericarditis hemorrágica y taponamiento cardíaco asociados a lupus eritematoso sistémico
Barrera-Ramírez, Carlos Felipe;Pineda-Pompa, Luis R;Melo, Mario;Valdez Castro, Ricardo;Medina-Gómez, Héctor;Godina-Alonso, Gustavo;Guzmán, Carlos E;
Archivos de cardiología de México , 2005,
Abstract: systemic lupus erythematosus is a chronic inflammatory autoimmune disorder that can affect any organ or system. although pericarditis is the most frequent cardiac manifestation of this entity, usually is not a life threatening situation. pericardial effusion causing cardiac tamponade is a very rare complication in lupus, with an incidence less than 2%. we report a case of pericardial tamponade due to sle with severe hemodynamic involvement in a 21-year-old woman associated to rapidly progressive glomerulonephritis, acute pancreatitis, acute acalculous cholecystitis, pleural effusion, hematologic, cutaneous and neurologic lupus activity. recognition of this rare manifestation of sle may be life saving.
Budd Chiari Syndrome in a Fifteen-Year Old Girl with Systemic Lupus Erythematosus
N Hussain, G Jaffery, AN Sabri, S Hasnain, N Mir
International Journal of Health Research , 2008,
Abstract: Budd Chiari Syndrome is a rare disease that results from the complication of venous thrombosis. In this case report, the syndrome is being reported in a 15 year old young Pakistani girl first diagnosed with Systemic Lupus Erythematosus (SLE) two years earlier. She was one of those on a one year regular follow-up in the Rheumatology Department of Fatimah Memorial Hospital, Lahore, Pakistan. It is believed that in this patient, Budd Chiari Syndrome resulted from hepatic veinous thrombosis due to the presence of Lupus anticoagulants. As the young girl was suffering from antiphospholipid syndrome secondary to lupus, this milder form of Budd-Chiari Syndrome was later treated in India with surgical shunts.
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