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Late Onset Juvenile Xanthogranuloma  [cached]
Punithwavathy K,Sentamilselvi G,Janaki V. R,Janaki C
Indian Journal of Dermatology , 1999,
Abstract: A 19 year old female was seen with multiple skin coloured and hyperpigmented macules, discrete as well as grouped papules and nodules of varying sizes distributed over the face, neck, extensor and flexor aspects of both upper and lower extremities including joints. The trunk was spared. Some of the lesions showed features of spontaneous regression. Investigations confirmed the diagnosis of juvenile xanthogranuloma. Lesions regressed satisfactorily with liquid nitrogen cryotherapy.
Alteraciones gonioscópicas del ángulo camerular en el glaucoma juvenil Gonioscopic alterations of the camerular angle in the juvenile glaucoma  [cached]
Zaadia Pérez Parra,Alexeide Castillo Pérez
Revista Cubana de Oftalmolog?-a , 2008,
Abstract: INTRODUCCIóN: El glaucoma juvenil es una entidad rara que se comporta de manera similar al glaucoma del adulto, en cuanto a sintomatología y evolución. MéTODOS: Realizamos un estudio retrospectivo comparativo de casos controles con el objetivo de describir las características gonioscópicas del ángulo camerular. RESULTADOS: En el glaucoma juvenil es frecuente el antecedente en familiares de primera línea. En el examen gonioscópico es más frecuente el ángulo abierto y la ausencia de alteraciones embrionarias evidentes en pacientes con glaucoma juvenil y en pacientes sanos. CONCLUSIONES: El glaucoma juvenil es una enfermedad multifactorial que se desarrolla en pacientes jóvenes que presentan o no alteraciones embrionarias del ángulo camerular. RECOMENDACIONES: Realizar pesquisa de glaucoma juvenil en pacientes con factores de riesgo de glaucoma aunque el estudio gonioscópico resulte aparentemente normal; además, especificar en el examen gonioscópico del paciente la extensión y localización de las alteraciones embrionarias. INTRODUCTION: Juvenile glaucoma is a rare disease that behaves in the same way as the adult glaucoma METHODS: A retrospective comparative case- control study was performed. with the objective of describing the gonioscopic characteristics of the camerular angle in juvenile glaucoma. RESULTS: A family history of glaucoma is common in the juvenile glaucoma. The open-angle glaucoma and the lack of evident embrionary alterations are the most frequent findings in the gonioscopic test in Juvenile Glaucoma and in healthy patients. CONCLUSIONS: Juvenile Glaucoma is a multifactorial disease, which develops in young patients presenting with embrionary alterations of the camerular angle or not. RECOMMENDATIONS: A screening should be carried out to look for juvenile glaucoma in patients with risk factors although the gonioscopic study seems to be normal, and also the gonioscopic exam of a patient should specify the extension and location of the embrionary alterations.
Glaucoma awareness among people attending ophthalmic outreach services in Southwestern Ethiopia
Addis Tenkir, Berhan Solomon, Amare Deribew
BMC Ophthalmology , 2010, DOI: 10.1186/1471-2415-10-17
Abstract: The main aim of this study was to assess the level of awareness of glaucoma among people attending outreach ophthalmic services.We conducted a cross-sectional survey in April 2009 of all people 40 years of age or older who presented during a two-week outreach service period in Agaro town, southwestern Ethiopia. Data on demographics and awareness of glaucoma were collected through face to face interview using a pretested structured questionnaire.340 people participated in the study. Their mean age was 54.5 (SD 10.6) years. About 43% were illiterates and 37.6% were farmers. Only eight people (2.4%) were aware of glaucoma. The association between awareness and attaining high school or better education was statistically significant (p < 0.0001).Awareness of glaucoma in this population is very low. An efficient information, education and communication (IEC) strategy needs to be designed to increase knowledge of the community about glaucoma so that early diagnosis and treatment of individuals with this condition may be possible.Glaucoma is the second leading cause of blindness worldwide [1]. Up to 50% of glaucoma patients are already blind in one eye at presentation in Africa including Ethiopia [2]. Eye health education that influences people to participate in regular ophthalmologic care may be an important step to detect glaucoma early, thereby preventing needless blindness. Not only can education and preventive eye care save needless suffering, it can also reduce the economic burden of the disease [3]. Subgroups of the population who are at highest risk both for developing the disease and having insufficient knowledge about it need to be identified and targeted in order to most effectively use resources for public education.The Department of Ophthalmology of Jimma University provides outreach ophthalmic activities in addition to regular services at its tertiary eye unit. The outreach activities include general eye health evaluation, refraction, trichiasis surgery and ca
Espesor corneal central en el glaucoma juvenil Central corneal thickness in juvenile glaucoma  [cached]
Maykel Rivera López,Yanet García Concha,Henry Pérez González,Sandra Jalilo Hernández
Revista de Ciencias M??dicas de Pinar del R?-o , 2012,
Abstract: Introducción: el glaucoma juvenil es una variedad poco común y sus manifestaciones clínicas pueden simular un glaucoma primario de ángulo abierto. Objetivo: evaluar el comportamiento del espesor corneal central en el glaucoma juvenil. Material y Método: se realizó un estudio analítico, longitudinal y prospectivo a 29 pacientes con glaucoma juvenil atendidos en la consulta especializada del centro oftalmológico y del hospital pediátrico de Pinar del Río, de junio de 2010 a diciembre de 2011. Resultados: la edad promedio fue de 18 a os, con una ligera mayoría de un 51.72 % de varones y de la raza blanca, sin valor estadístico. El 51.72 % refirieron antecedentes familiares de glaucoma. El 93.10 % presentó un ángulo abierto, y el 65.51 % tenían espesor corneal central inferiores a 539μm predominando en este grupo, de forma altamente significativa los valores de presión intra ocular entre 22-25 mmHg en un 84.21 %. No hubo relación entre espesor corneal central bajos y alteraciones papilares glaucomatosa, y sí existió relación estadística significativa entre valores de presión intra ocular superiores a 22 mmHg y excavaciones mayor de 0.5 con un 92.85 %. Conclusión: ambos sexos y razas se afectaron por igual predominando los pacientes con ángulo abierto, siendo los antecedentes familiares importantes para el diagnóstico y encontrando relación significativa entre el espesor corneal bajo y cifras elevadas de presión intra ocular, no así con el da o papilar glaucomatoso el cual sí se relacionó significativamente con valores elevados de presión intra ocular. Introduction: juvenile glaucoma is an uncommon variety and its clinical manifestations can simulate a primary glaucoma of open angle. Objective: to assess the behavior of central corneal thickness in juvenile glaucoma. Material and Method: an analytical, longitudinal and prospective study was carried out including 29 patients suffering from juvenile glaucoma who attended to the specialized center of Ophthalmology at “Pepe Portilla” children hospital, Pinar del Rio from June 2010 to December 2011. Results: the average age was 18, with a majority of male patients (51.72 %), and Caucasian, without statistical value. This figure (51.72 %) referred familial history of glaucoma; 93.10 % presented open angle glaucoma and 65.51% had a central corneal thickness inferior to 539 μm prevailing in this group a highly significant value of intraocular pressure between 22-25 mmHg was present in the 84.21% of them. No relationship was found between low-central corneal thicknesses and papillary-glaucoma alterations, a significa
Recurrent Respiratory Papillomatosis (RRP) - Juvenile Onset
Sara W. Dyrstad,Krishna A. Rao
Clinical Medicine : Oncology , 2008,
Abstract: In this article, we describe the treatment of long standing juvenile-onset recurrent respiratory papillomatosis (JORRP) with eventual transformation to carcinoma in a patient who lived to the age of 73. Treatment modalities consisted of bronchoscopy and local excision initially. Later, YAG and CO2 laser debulking were used. Radiotherapy, chemotherapy with carboplatin (300 mg/m2) and 5-FU (600 mg/m2), oral methotrexate (5–7.5 mg/week), pegylated Interferon, indole-3-carbamide, and intralesional cidofovir were also utilized in the treatment of this patient. Except for methotrexate, each of the treatment regimens used in this patient, initially decreased growth of the papillomas and improved symptoms experienced by the patient. Interestingly, we found that this patient’s long standing JORRP initially responded to a chemo- therapy regimen of 4 cycles of carboplatin (300 mg/m2) and 5-FU (600 mg/m2) as well. Ultimately, the disease became resistant to all forms of treatment and progressed. The patient eventually succumbed to the disease after an approximate 77 year course.
Absonifibula estuarina sp. n. (Monogenea: Diclidophoridae) parasite of juvenile Cynoscion guatucupa (Osteichthyes) from southwestern Atlantic Ocean
Santos, Cláudia Portes;Tomás Timi, Juan;
Memórias do Instituto Oswaldo Cruz , 2009, DOI: 10.1590/S0074-02762009000700004
Abstract: absonifibula estuarina sp. n. (diclidophoridae, absonifibulinae), is described from the gills of juvenile striped weakfish, cynoscion guatucupa (cuvier), from the southwestern atlantic, argentinean coast. this marine fish migrates to estuarine areas to spawn where exclusively juveniles are found parasitized; adult fish in marine water were never found to be parasitized by this monogenean. a. estuarina sp. n. is characterized mainly by the pedunculate clamps dissimilar in size, the shape of anterior jaw with sclerite 'a' attached to a sub-trapezoidal lamellate extension and fused to sclerites 'c' and 'd'. it differs from absonifibula bychowskyi lawler & overstreet, 1976, the only known species of the genus, in the shape and arrangement of the genital corona, which is armed with six similar hooks disposed in circle and the sub-trapezoidal shape of lamellate extension ('b'). the restriction to juvenile sciaenids is a shared feature among the absonifibulinae indicating an estuary-dependent life cycle.
Phylogeography and Demographic History of Babina pleuraden (Anura, Ranidae) in Southwestern China  [PDF]
Zejun Li, Guohua Yu, Dingqi Rao, Junxing Yang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034013
Abstract: Factors that determine genetic structure of species in southwestern China remain largely unknown. In this study, sequences of two mitochondrial genes (COI and cyt b) were determined to investigate the phylogeography and demography of Babina pleuraden, a pond frog endemic to southwestern China. A total of 262 individuals from 22 populations across the entire range of the species were collected. Our results indicate that B. pleuraden comprises five well-supported mitochondrial lineages roughly corresponding to five geographical areas. The phylogeographic structure of B. pleuraden has been shaped primarily by the unique regional responses of the Yunnan Plateau to the rapid uplift of the Qinghai-Tibetan Plateau occurred c. 2.5 Mya (B phrase of Qingzang Movement) and climatic oscillation during middle Pleistocene (c. 0.64–0.36 Mya), rather than by the paleo-drainage systems. The present wide distribution of the species has resulted from recent population expansion (c. 0.053–0.025 Mya) from multiple refugia prior to the Last Glacial Maximum, corresponding to the scenario of “refugia within refugia”.
Elbow monoarthritis: an atypical onset of juvenile idiopathic arthritis Elbow monoarthritis: an atypical juvenile idiopathic arthritis onset  [cached]
A. Marino,I. Pagnini,S. Savelli,D. Moretti
Reumatismo , 2012, DOI: 10.4081/reumatismo.2012.175
Abstract: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition in childhood and an important cause of short and long term disability. Oligoarthritis is defined as an arthritis that affects four o fewer joints during the first 6 months of disease. The large majority of patients within this category belongs to a quite well defined disease which is not observed in adults. It is characterized by an early onset (before 6 years of age), an asymmetric arthritis involving mainly large joints, a female predilection, a high frequency of positive antinuclear antibodies (ANA), a high risk for developing chronic iridocyclitis and consistent HLA associations. We describe 3 clinical cases who presented monoarthritis of the elbow as early sign of oligoarticular JIA. All patients showed inflammatory markers elevation and 2/3 were ANA positive. MRI showed the presence of synovial inflammation without bone involvement. Intraarticular triamcinolone hexacetonide, led to remission in one case, while in the other two there was a re-activation of the disease treated with NSAIDs and/or MTX. The reported cases represent 0.6% of 490 patients with JIA followed by our unit in the last 10 years. Cases of exclusive involvement of the elbow at onset of JIA in literature are rare. Therefore, we report 3 cases of monoarthritis of the elbow as initial sign of oligoarticular JIA, a very atypical onset of this disease. Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition in childhood and an important cause of short and long term disability. Oligoarthritis is defined as an arthritis that affects four o fewer joints during the first 6 months of disease. The large majority of patients within this category belongs to a quite well defined disease which is not observed in adults. It is characterized by an early onset (before 6 years of age), an asymmetric arthritis involving mainly large joints, a female predilection, a high frequency of positive antinuclear antibodies (ANA), a high risk for developing chronic iridocyclitis and consistent HLA associations. We describe 3 clinical cases who presented monoarthritis of the elbow as early sign of oligoarticular JIA. All patients showed inflammatory markers elevation and 2/3 were ANA positive. MRI showed the presence of synovial inflammation without bone involvement. Intraarticular triamcinolone hexacetonide, led to remission in one case, while in the other two there was a re-activation of the disease treated with NSAIDs and/or MTX. The reported cases represent 0.6% of 490 patients with JIA followed by
Association analysis of cigarette smoking with onset of primary open-angle glaucoma and glaucoma-related biometric parameters  [cached]
Wang Degui,Huang Yuqiang,Huang Chukai,Wu Pengfei
BMC Ophthalmology , 2012, DOI: 10.1186/1471-2415-12-59
Abstract: Background To date, studies on the role played by cigarette smoking in primary open-angle glaucoma (POAG) remains controversial. The current study evaluated cigarette smoking as a risk factor of POAG and its relationships with vertical cup-to-disc ratio (VCDR), central corneal thickness (CCT) and intraocular pressure (IOP) in a Chinese cohort. Methods In a total of 248 unrelated individuals including 30 juvenile-onset POAG (JOAG), 92 adult-onset POAG (AOAG) and 126 sex-matched senile cataract controls, underwent comprehensive ophthalmic examination. Their smoking was obtained and documented by questionnaire. Association of cigarette smoking with POAG was performed using logistic regression controlled for age and sex. Effects of cigarette smoking on VCDR, IOP and CCT were analyzed with multiple linear regression. Results In either JOAG or AOAG, no association of cigarette smoking was found with disease onset (P = 0.692 and 0.925 respectively). In controls and JOAG, no significant effects of smoking were found on VCDR, IOP or CCT (all P > 0.05). Smoking was found to be correlated with decreased CCT in AOAG and combined POAG (JOAG + AOAG) (P = 0.009 and 0.003), but no association with VCDR or IOP was observed (P > 0.05). Conclusions Although cigarette smoking was not found to be risk factor for onset of POAG, it was correlated with CCT in AOAG, and thus might still play a role in the disease course, especially for AOAG.
Late-Onset Endophthalmitis Secondary to Exposed Glaucoma Tube Implant in a Rare Case of Paediatric Glaucoma
Akshatha Ranganath,Adnan Hashim
Case Reports in Ophthalmological Medicine , 2011, DOI: 10.1155/2011/183647
Abstract: Glaucoma drainage implants (GDIs) are used to treat paediatric glaucoma resistant to conventional medical and surgical treatment, achieving good intraocular pressure (IOP) control and long-term success. Late endophthalmitis is a rare complication that may develop following GDI surgery. A 17-year-old male presented with acute endophthalmitis 2 years after Ahmed glaucoma valve implantation with pericardial patch graft for management of refractory glaucoma secondary to congenital ectropion uveae. The glaucoma tube was exposed due to erosion of the overlying conjunctiva with no visible pericardial graft. After control of active infection, he underwent tube revision surgery whereby the exposed tube was retained and repatched with a double-thickness pericardial patch graft. He did well following surgery with good control of IOP and restoration of vision. Conjunctival dehiscence with graft melting over the GDI tube presented a major risk factor for endophthalmitis. Prompt surgical revision of an exposed tube is highly recommended to avoid ocular morbidity.
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