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Cobalt(II) chloride catalyzed one-pot synthesis of α-aminonitriles
De Surya K
Beilstein Journal of Organic Chemistry , 2005, DOI: 10.1186/1860-5397-1-8
Abstract: A simple and efficient method has been developed for the synthesis of α-aminonitriles by a one-pot three- component condensation of aldehydes, amines, and potassium cyanide in acetonitrile in the presence of a catalytic amount of CoCl2 at room temperature.
Catalyst Free One-Pot Synthesis of Chromeno Quinolines and Their Antibacterial Activity  [PDF]
Sruthi Vasamsetty, Sunitha Medidi, Satheesh Ampolu, Ravi Kumar Majji, Mastan Rao Kotupalli, Chikurumilli China Satyanarayana, Annapurna Nowduri, Paul Douglas Sanasi
Green and Sustainable Chemistry (GSC) , 2017, DOI: 10.4236/gsc.2017.72011
Abstract: An efficient greener one pot synthesis of dimethyl-dihydro-7H-chromeno[3, 2-h]quinolin-8(9H)-one derivatives has been synthesized through cyclization of aromatic aldehyde, dimidone and 8-hydroxy-quinoline through one-pot condensation method is described. The synthesized compounds are screened for further biological activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Bacillus using cut plate method and disc diffusion method.
New One-Pot Methodologies for the Modification or Synthesis of Alkaloid Scaffolds  [PDF]
Amir E. Wahba,Mark T. Hamann
Marine Drugs , 2010, DOI: 10.3390/md8082395
Abstract: There are several avenues by which promising bioactive natural products can be produced in sufficient quantities to enable lead optimization and medicinal chemistry studies. The total synthesis of natural products is an important, but sometimes difficult, approach and requires the development of innovative synthetic methodologies to simplify the synthesis of complex molecules. Various classes of natural product alkaloids are both common and widely distributed in plants, bacteria, fungi, insects and marine organisms. This mini-review will discuss the scope, mechanistic insights and enantioselectivity aspects of selected examples of recently developed one-pot methods that have been published in 2009 for the synthesis of substituted piperidines, quinolizidines, pyrrolidines, hexahydropyrrolizines, octahydroindolizines and g-lactams. In addition, progress on the synthesis of b-carboline (manzamine) alkaloids will also be discussed.
One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives  [PDF]
Hui Zheng,Yi-Jia Mei,Kui Du,Xian-Ting Cao,Peng-Fei Zhang
Molecules , 2013, DOI: 10.3390/molecules181113425
Abstract: A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions. The blank and control experiments reveal that trypsin from porcine pancreas (PPT) displayed great catalytic activity to promote this reaction and showed a wide tolerance range towards different substrate amines. This trypsin-catalyzed multicomponent conversion method provides a novel strategy to synthesize thiazole derivatives and expands the application of enzymes in organic synthesis.
One-Pot Synthesis of Dimethyl Carbonate over Basic Zeolite Catalysts  [PDF]
Wenshuai Xu, Shengrong Ji, Wei Quan, Jianqiang Yu
Modern Research in Catalysis (MRC) , 2013, DOI: 10.4236/mrc.2013.22A004

One-pot synthesis of dimethyl carbonate (DMC) from methanol, propylene oxide (PO) and carbon dioxide has been investigated using the basic zeolites as catalysts. Among the zeolites studied, Beta showed the best catalytic performance for DMC production. That the desilication of zeolite structure resulted in a hierarchical porosity of Beta, leading to more amount of KOH can be loaded on the surface of zeolite and therefore enhancing the base strength of the catalyst was proposed to be the reason for improved catalytic performance.

Cerium (IV) Ammonium Nitrate (CAN) Catalyzed One-pot Synthesis of 2-Arylbenzothiazoles  [PDF]
Fawzia Al-Qalaf,Ramadan Ahmed Mekheimer,Kamal Usef Sadek
Molecules , 2008, DOI: 10.3390/molecules13112908
Abstract: A one-pot synthesis of 2-arylbenzothiazoles from the reaction of 2-aminothiophenol and aromatic aldehydes catalysed by cerium (IV) ammonium nitrate (CAN) is reported.
Lanthanide nitrates as Lewis acids in the one-pot synthesis of 1,2,4-oxadiazole derivatives
Vale, Juliana A.;Faustino, Wagner M.;Zampieri, Davila de S.;Moran, Paulo J. S.;Rodrigues, José A. R.;de Sá, Gilberto F.;
Journal of the Brazilian Chemical Society , 2012, DOI: 10.1590/S0103-50532012005000002
Abstract: in this work we report the use of lanthanide nitrates [ln(no3)3] acting as catalyst in direct one-pot synthesis of 3-benzoyl- and 3-acetyl-1,2,4-oxadiazoles derivatives from ketones, nitriles and nitric acid. this is the first example of one-pot synthesis of benzoyl- and acetyl 1,2,4-oxadiazoles derivatives preparation using acetophenones derivates with electron-donator groups.
Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol
Mukund G. Kulkarni,Sanjay W. Chavhan,Mahadev P. Shinde,Dnyaneshwar D. Gaikwad
Beilstein Journal of Organic Chemistry , 2009, DOI: 10.3762/bjoc.5.4
Abstract: A zeolite-catalyzed, simple, one-pot, solvent-free, cost effective, and environmentally benign process for the synthesis of dihydropyrimidones is described. This reaction is scaleable to multigram scale and the catalyst is recyclable. This methodology has resulted in an efficient synthesis of monastrol, a potent inhibitor of kinesin Eg5.
A Novel and One-Pot Synthesis of 6-arylpyrimidin-4-ol
Jitendra M. Gajera,Shital N. Tondlekar,Laxmikant A. Gharat
Organic Chemistry International , 2008, DOI: 10.1155/2008/810678
Abstract: We have developed a novel and one-pot synthesis of 6-arylpyrimidine-4-ol by reacting commercially available alkyl 3-oxo-3-arylpropanoate with formamide in the presence of stoichiometric amount of ammonium acetate.
A Facile Synthesis of Polysubstituted Pyrroles by One-Pot Three-Component Reaction  [PDF]
Hossein Anaraki-Ardakani,Maziar Noei,Mina Karbalaei-Harofteh,Shahab Zomorodbakhsh
Journal of Chemistry , 2012, DOI: 10.1155/2012/915861
Abstract: A new and efficient one-pot synthesis of polysubstituted pyrrole derivatives by three-component reaction between dialkyl acetylenedicarboxylates, triphenylphosphine, 2-aminopyridin derivatives in the presence of arylglyoxals is described. The reactions were performed in dichloromethane at room temperature and neutral conditions and afforded high yields of products.
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