oalib
Search Results: 1 - 10 of 100 matches for " "
All listed articles are free for downloading (OA Articles)
Page 1 /100
Display every page Item
Antioxidant status of atorvastatin in hypercholesterolemic patients  [PDF]
MOHAMMAD A. NASAR,ABDALLA JARRARI,MOHAMMAD A. NASEER,TARANNUM F. SUBHANI
Journal of the Serbian Chemical Society , 2009,
Abstract: This study was an attempt to establish the extent of increased oxidative stress in hypercholesterolemic patients and to evaluate the effect of atorvastatin on the oxidative stress and antioxidant status. Blood samples of 15 subjects (age and sex matched) from three groups: group I (healthy subjects), group II (hypercholesterolemic patients with atorvastatin treatment) and group III (hypercholesterolemic patients without any hypolipidemic drug) were taken and centrifuged to separate the plasma, which was used for the determination of vitamin E. The separated cells were washed thrice with 0.90 % w/v cold normal saline and used for the assay of the percentage hemolysis of the RBCs, and the determination of malondialdehyde, superoxide dismutase and hemoglobin. The levels of oxidative stress were higher in the hypercholesterolemic in comparison to the control and atorvastatin group. The levels of antioxidants were higher in the atorvastatin group than in the hypercholesterolemic one but were lower than the controls. From these findings, it was concluded that there is an increase in oxidative stress in hypercholesterolemia but it decreased significantly after 2 months of atorvastatin therapy and antioxidant status also improves in patients taking atorvastatin.
Effects of Zinc Supplementation on Plasma Copper/Zinc Ratios, Oxidative Stress, and Immunological Status in Hemodialysis Patients
Chih-Hung Guo, Chia-Liang Wang
International Journal of Medical Sciences , 2013,
Abstract: Background: Patients undergoing hemodialysis (HD) have low plasma levels of zinc (Zn), high plasma levels of copper (Cu), and exhibit increased oxidative stress, inflammation, and immune abnormalities. We evaluated the effects of Zn supplementation on abnormal plasma Cu/Zn ratios and clinical outcomes in HD patients. Design and Methods: Patients on long-term HD with lower than normal plasma concentrations of Zn (< 80 mg/dL) were randomized to receive daily oral Zn supplements (n = 40) or no supplements (n = 25) for eight weeks. Age- and sex-matched healthy individuals served as a control group (n = 38). A number of clinical parameters were measured before and after the supplementation period. Results: Compared with healthy subjects, patients had significantly elevated plasma Cu concentrations and Cu/Zn ratios, as well as higher levels of oxidative stress and pro-inflammatory cytokines. Patients who received Zn supplements for eight weeks had higher plasma concentrations of Zn and lower concentrations of Cu, along with reduced Cu/Zn ratios, oxidative stress status, and inflammatory responses compared to patients who did not receive Zn. Patients receiving Zn also showed significantly higher percentages of CD4 and CD19 lymphocytes, and elevated CD4/CD8 ratios. Conclusions: Zn supplementation ameliorates abnormally high plasma Cu/Zn ratios and may reduce oxidative stress, improve inflammatory status, and maintain immune function in patients undergoing long-term HD.
Bioactive Constituents from “Triguero” Asparagus Improve the Plasma Lipid Profile and Liver Antioxidant Status in Hypercholesterolemic Rats  [PDF]
Sara Vázquez-Castilla,Rocío De la Puerta,María Dolores Garcia-Gimenez,María Angeles Fernández-Arche,Rafael Guillén-Bejarano
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms141121227
Abstract: We have previously shown that the Andalusian-cultivated Asparagus officinalis L. “triguero” variety produces hypocholesterolemic and hepatoprotective effects on rats. This asparagus is a rich source of phytochemicals although we hypothesized there would be some of them more involved in these functional properties. Thus, we aimed to study the effects of asparagus (500 mg/kg body weight (bw)/day) and their partially purified fractions in flavonoids (50 mg/kg bw/day), saponins (5 mg/kg bw/day) and dietary fiber (500 mg/kg bw/day) on oxidative status and on lipid profile in rats fed a cholesterol-rich diet. After 5 weeks treatment, plasma lipid values, hepatic enzyme activities and liver malondialdehyde (MDA) concentrations were measured. With the exception of the saponin fraction (SF), the administration of lyophilized asparagus (LA), fiber fraction (FF), and flavonoid fraction (FVF) to hypercholesterolemic rats produced a significant hypolipidemic effect compare to a high-cholesterol diet (HCD). In addition, the LA and FVF groups exhibited a significant increase in enzyme activity from multiple hepatic antioxidant systems including: superoxide dismutase, catalase, and gluthatione reductase/peroxidase as well as a decrease in MDA concentrations compared to HCD group. These results demonstrate that “triguero” asparagus possesses bioactive constituents, especially dietary fiber and flavonoids, that improve the plasma lipid profile and prevent hepatic oxidative damage under conditions of hypercholesterolemia.
The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients
Coimbra, S.R.;Lage, S.H.;Brandizzi, L.;Yoshida, V.;da Luz, P.L.;
Brazilian Journal of Medical and Biological Research , 2005, DOI: 10.1590/S0100-879X2005000900008
Abstract: although red wine (rw) reduces cardiovascular risk, the mechanisms underlying the effect have not been identified. correction of endothelial dysfunction by rw flavonoids could be one mechanism. we measured brachial artery reactivity by high-resolution ultrasonography, plasma lipids, glucose, adhesion molecules (icam-1 and vcam), and platelet function in 16 hypercholesterolemic individuals (8 men and 8 women; mean age 51.6 ± 8.1 years) without other risk factors. twenty-four normal subjects were used as controls for vascular reactivity. subjects randomly received rw, 250 ml/day, or purple grape juice (gj), 500 ml/day, for 14 days with an equal wash-out period. at baseline, all 16 subjects were hypercholesterolemic (mean ldl = 181.0 ± 28.7 mg/dl) but hdl, triglycerides, glucose, adhesion molecules, and platelet function were within normal limits. brachial artery flow-mediated dilation was significantly decreased compared to controls (9.0 ± 7.1 vs 12.1 ± 4.5%; p < 0.05) and increased with both gj (10.1 ± 7.1 before vs 16.9 ± 6.7% after: p < 0.05) and rw (10.1 ± 6.4 before vs 15.6 ± 4.6% after; p < 0.05). rw, but not gj, also significantly increased endothelium-independent vasodilation (17.0 ± 8.6 before vs 23.0 ± 12.0% after; p < 0.01). gj reduced icam-1 but not vcam and rw had no effect on either molecule. no significant alterations were observed in plasma lipids, glucose or platelet aggregability with rw or gj. both rw and gj similarly improved flow-mediated dilation, but rw also enhanced endothelium-independent vasodilation in hypercholesterolemic patients despite the increased plasma cholesterol. thus, we conclude that gj may protect against coronary artery disease without the additional negative effects of alcohol despite the gender.
The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients  [cached]
Coimbra S.R.,Lage S.H.,Brandizzi L.,Yoshida V.
Brazilian Journal of Medical and Biological Research , 2005,
Abstract: Although red wine (RW) reduces cardiovascular risk, the mechanisms underlying the effect have not been identified. Correction of endothelial dysfunction by RW flavonoids could be one mechanism. We measured brachial artery reactivity by high-resolution ultrasonography, plasma lipids, glucose, adhesion molecules (ICAM-1 and VCAM), and platelet function in 16 hypercholesterolemic individuals (8 men and 8 women; mean age 51.6 ± 8.1 years) without other risk factors. Twenty-four normal subjects were used as controls for vascular reactivity. Subjects randomly received RW, 250 ml/day, or purple grape juice (GJ), 500 ml/day, for 14 days with an equal wash-out period. At baseline, all 16 subjects were hypercholesterolemic (mean LDL = 181.0 ± 28.7 mg/dl) but HDL, triglycerides, glucose, adhesion molecules, and platelet function were within normal limits. Brachial artery flow-mediated dilation was significantly decreased compared to controls (9.0 ± 7.1 vs 12.1 ± 4.5%; P < 0.05) and increased with both GJ (10.1 ± 7.1 before vs 16.9 ± 6.7% after: P < 0.05) and RW (10.1 ± 6.4 before vs 15.6 ± 4.6% after; P < 0.05). RW, but not GJ, also significantly increased endothelium-independent vasodilation (17.0 ± 8.6 before vs 23.0 ± 12.0% after; P < 0.01). GJ reduced ICAM-1 but not VCAM and RW had no effect on either molecule. No significant alterations were observed in plasma lipids, glucose or platelet aggregability with RW or GJ. Both RW and GJ similarly improved flow-mediated dilation, but RW also enhanced endothelium-independent vasodilation in hypercholesterolemic patients despite the increased plasma cholesterol. Thus, we conclude that GJ may protect against coronary artery disease without the additional negative effects of alcohol despite the gender.
Oxidative Status and Plasma Prolidase Activity in Patients with Gallstones
Alpaslan TERZ?,Sacit ?OBAN,Fahrettin YILDIZ,Murat KAYA
Trakya Universitesi Tip Fakultesi Dergisi , 2010,
Abstract: Objective: The aim of our study was to investigate the oxidative and antioxidative status of plasma and plasma prolidase enzyme activity on gallstone disease. Material and Methods: The study group included 35 patient with gallstone disease and 30 healthy volunteers as control subjects. Plasma prolidase activity and oxidative-antioxidative parameters were measured. Antioxidative status of plasma was evaluated by measuring total antioxidant capacity. To determine oxidative status; total oxidant status and oxidative stress index were deermied. Results: Total antioxidant capacity levels of plasma were lower in the patients with gallstone disease than in controls (p<0.001). In contrast, total oxidant status levels and oxidative stress index values were higher in the patients than in controls (p<0.05 and p<0.001, respectively). Beside these, plasma prolidase activity was significantly lower in the patients than controls (p<0.001). Conclusions: The present results indicated that the oxidant parameters increased and antioxidant parameters decreased in patients with gallstones, and that these patients were exposed to oxidative stress.
Rosuvastatin Reduces Plasma Small Dense Ldl-Cholesterol Predominantly in Non-Diabetic Hypercholesterolemic Patients  [PDF]
Gen Yoshino, Saburo Nakano, Tomoko Matsumoto, Eiichi Murakami, Toshisuke Morita, Koji Kuboki
Pharmacology & Pharmacy (PP) , 2012, DOI: 10.4236/pp.2012.31011
Abstract: Aims: Small dense LDL (sdLDL) cholesterol is considered a cardiovascular risk. Our purpose in this study was to evaluate the efficacy of rosuvastatin in reducing sdLDL and large buoyant LDL (lbLDL-C) in hypercholesterolemia. Methods: Fifty-six patients with a mean baseline LDL-cholesterol (LDL-C) concentration of 173.9 ± 40.5 mg/dL were treated with rosuvastatin 2.5 mg/day for 12 weeks. LDL-C, sdLDL-C, and apolipoprotein (apo) B were assessed and l lbLDL-C was calculated (LDL-C minus sdLDL-C). Results: After 12-week treatment with rosuvastatin 2.5mg, sdLDL-C and lbLDL-C were significantly reduced from 62.1 ± 23.8 mg/dL to 34.0 ± 13.4 mg/dL, p <0.001 and 112.7 ± 34.9 mg/dL to 77.2± 29.2 mg/dL, p < 0.001 respectively, and sdLDL-C/lbLDL-C ratio and apo B also decreased significantly, from 0.36 ± 0.02 to 0.32 ± 0.02, p < 0.005 and 134.2 ± 4.3 to 93.6 ± 3.5 mg/dl, p < 0.001, respectively. In diabetic subjects there was significant correlation between percent reductions in the plasma triglyceride and sdLDL-C/ lbLDL-C ratio (r = 0.58, p < 0.005), but not between the percentage decrease in plasma triglyceride and sdLDL-C. Conclusions: Treatment with rosuvastatin is associated with significant reduction in sdLDL, lbLDL and sdLDL/lbLDL ratio.
Effects of Glycaemic Status on Plasma Levels of Calcium, Chromium, Copper, Iron, Magnesium, Selenium and Zinc in Diabetic Rats
International Journal of Diabetes Research , 2012, DOI: 10.5923/j.diabetes.20120105.04
Abstract: There is increasing evidence of the involvement of minerals in the pathogenesis of diabetes mellitus and its complications. In order to determine the effects of glycaemic status on the plasma levels of calcium, chromium, copper, iron, magnesium, selenium and zinc, 24 albino rats weighing 105-162 g grouped into 4 {non-diabetic control (NDC), diabetic control (DC), and diabetic treated with 10mg/Kg body weight (DT10) and 20mg/Kg body weight (DT20) of glucophage respectively}, were investigated. In addition to fasting plasma glucose, plasma levels of elements were determined by atomic absorption spectrophotometer. Results show that diabetic rats had lower levels of the elements in comparison to their non-diabetic counterparts but only magnesium {37.5 (1.9) vs. 48.8 (3.4); p = 0.033)}, copper {13.5 (0.9) vs. 24.9 (0.7); p = 0.032)} and zinc {34.9 (0.7) vs. 58.2 (0.6); p = 0.013)} were statistically significant. Again, higher levels of the elements were observed in diabetic treated rats when compared to the diabetic control but only copper {22.5 (0.3) vs. 13.5 (0.9), p = 0.043)} and zinc {49.6 (0.7) vs. 34.9 (0.7), p = 0.028)} were found to be significant, at higher dosage of the antihyperglycaemic agent. Plasma glucose was negatively correlated with copper (r =-0.273; p = 0.017), magnesium (r = -0.212; p = 0.024 and zinc (r = -0.245; p = 0.019), with no significant relationship observed among the elements. We conclude that hyperglycaemia of diabetes alters plasma mineral levels with plasma copper, magnesium and zinc being more responsive to alterations in glycaemic status than calcium, chromium, iron and selenium.
Status of plasma nitric oxide and non-enzymatic antioxidants before and after antipsychotic treatment in Nigerian patients with schizophrenia  [cached]
Ganiyu Olatubosun Arinola,O B Idonije
Journal of Research in Medical Sciences , 2009,
Abstract: BACKGROUND: Recently, it is proposed that oxidant-antioxidant imbalance may have a role in the pathophysiology of schizophrenia. The present study was performed to assess differences in plasma levels of nitric oxide (as oxidant), caeruloplasmin (secondary antioxidant), and antioxidant trace metals (Zn, Se, Mn, Cu and Fe) in patients with schizophrenia compared with healthy controls. Our secondary aim was to further evaluate the impact of psychopharmacologic treatment on these parameters. METHODS: Plasma levels of nitric oxides (NO), caeruloplasmin, zinc (Zn), selenium (Se), manganese (Mn), copper (Cu) and iron (Fe) in patients with schizophrenia before (n = 15) and after antipsychotic drug treatment (n = 20) were compared with those of healthy controls (n = 20). Convenient sampling method was used for the selection of subjects. NO was estimated by the use of Griess method, caeruloplasmin was estimated by the use of immunodiffusion method and antioxidant trace metals was estimated by the use of atomic absorption spectrophotometer. RESULTS: The levels of Cu and caeruloplasmin were not significantly different while Fe and Se were significantly reduced in both groups of schizophrenic patients compared with the controls. Zn was significantly elevated in medicated schizophrenics compared with drug-free patients or controls. NO was significantly elevated in drug free patients with schizophrenia compared with controls or treated patients. CONCLUSIONS: Our findings suggest the application of management strategies that will reduce NO but will increase antioxidant trace metals in patients with schizophrenia. KEYWORDS: Schizophrenia, antioxidant defense system, antioxidant status, oxidative Stress.
Assessment of plasma and salivary antioxidant status in patients with recurrent aphthous stomatitis
Sudhanshu Saxena
RSBO , 2011,
Abstract: Objective: The purpose of this study was to evaluate the antioxidant levels in plasma and saliva of patients with recurrent aphthous stomatitis (RAS) and healthy controls. Material and methods: Forty patients with RAS and 40 health controls were included into the study. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) activities and uric acid (UA) levels were measured in plasma and saliva. Chi-square and Student’s t-test was used to estimate the significance between parameters. P value less than 0.05 was considered statistically significant. Results: Plasma analysis showed significantly decreased SOD and CAT activities, and UA level in RAS patients compared to control group. Plasma GSHPx activity was significantly higher in RAS patients. In saliva, SOD and CAT activities, and UA levels were significantly higher in RAS patients, while GSHPx activity was lower compared to control. Conclusion: Plasma and saliva antioxidant system is affected in RAS patients and both may be considered as an appropriate indicator of antioxidant status of body.
Page 1 /100
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.