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Chemical constituents from Aegle marmelos
Laphookhieo, Surat;Phungpanya, Chalita;Tantapakul, Cholpisut;Techa, Somsak;Tha-in, Suphara;Narmdorkmai, Wanwasan;
Journal of the Brazilian Chemical Society , 2011, DOI: 10.1590/S0103-50532011000100024
Abstract: a new natural product oxazoline derivative named aeglemarmelosine (1) along with eight known compounds (2-9) were isolated from roots and twigs of aegle marmelos. compounds 1-6 were isolated from the roots whereas compounds 7-9 were obtained from twigs. compounds 5 and 6 were also detected from the twigs. all structures were characterized by extensive 1d and 2d nmr spectroscopic methods.
Antioxidant activity of Aegle marmelos and Psidium guajava leaves  [PDF]
International Journal of Medicinal and Aromatic Plants , 2012,
Abstract: Aegle marmelos, Bilwa (AM) and Psidium guajava, Guava, (PG) leaves were screened for phytochemicals by sequential extraction using a series of solvents. The antioxidant components such as -carotene, α-Tocopherol, glutathione, ascorbic acid, total polyphenols and flavonoids were also analyzed. In addition, the leaves were extracted with methanol (ME), ethanol (EE) and water (WE) and the polyphenol content, antioxidant activities by 2, 2; - diphenyl 1-picryl hydrazyl (DPPH) radical scavenging method and reducing power was determined. Majority of phytochemicals were found in methanol and water extracts of Aegle marmelos, methanol and water extracts and in Psidium guajava, terpenoids and steroids were found in all the sequential extracts. Aegle marmelos was rich in tocopherols, glutathione, ascorbic acid and flavonoids, whereas Psidium guajava, was rich in -carotene and total polyphenols. The three extracts showed varying degree of antioxidant efficacy in each assay. Water extract (WE) of both the samples showed maximum radical scavenging activity and reducing power. In Psidium guajava extracts with high polyphenol content showed maximum antioxidant activity. Results indicate that the Aegle marmelos and Psidium guajava has the potential to be utilized as sources of natural antioxidants especially the polyphenols.
P. Sandhya et al.
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Plant products served as an alternative to synthetic products because of local accessibility, eco friendly nature and lower prices. Natural gums and mucilages are widely explored as pharmaceutical excipients. The present study was undertaken to separate mucilage from unripe fruits of Aegle marmelos (L) Corr. and explore its use as binder in tablets. The binding properties at different concentrations of mucilage were evaluated using Paracetamol as model drug. Mucilage at 3%w/w was found to be comparable with 10%w/w of starch paste. The drug release studies indicated that Aegle marmelos mucilage could be considered as a potential binding agent.
Aegle marmelos:A Review on its Medicinal Properties  [PDF]
Pushpendra K. Patel,Jyoti Sahu,Lokesh Sahu,Narendra K.
International Journal of Pharmaceutical and Phytopharmacological Research , 2012,
Abstract: Present generation is a fast moving generation and no doubt about the potency of allopathic medicine, they provide fast result, but the darkest side of this medicine is their several side effects and contraindications. On the other hand the plants are good substitution for those medicines because of their less or no side effect and their ability to cure the problem from their root. The present study is based on the pharmacological activity of Aegle marmelos, commonly known as a bael in India. This plant is having great potential to cure the disease like diabetes, cholesterol, peptic ulcer, inflammation, diarrhoea, and dysentery, anticancer, cardio protective, anti bacterial, anti fungal, radio protective, anti pyretic, analgesic, constipation, respiratory infection, antioxidant, hepatoprotective, wound healing and many more. The present review summarizes the scientific information of various aspects of Aegle marmelos plant used in traditional system of medicine for variety of purpose.
Indian Streams Research Journal , 2013,
Abstract: In this study, we report biosynthesis of copper nanoparticles was done using Aegle Marmelos leaf extract. First we prepared leaf extract of Aegle Marmelos in deionised water. This extract added to 1mMol of copper chloride solution and we observed the change in color of the solution from colorless to colored solution, this indicates that there is a formation of Cu nanoparticles. These biosynthesized Cu nanoparticles were characterized with the help of X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR). It was observed that the Aegle Marmelos leaf extract can reduce copper ions into copper nanoparticles within 8 to 10 min of reaction time.
Fruit Gum of Aegle marmelos as Pharmaceutical Aid
D.N. Patil,A.R. Kulkarni,B.S. Patil
International Journal of Pharmacology , 2010,
Abstract: In the present study have formulated the oral tablets of paracetamol by using Aegle marmelos fruit gum as a binder. The four different tablet formulations were prepared by wet granulation method. The binder concentrations used in the formulation were 2, 4, 6 and 8% w/v of A. marmelos fruit gum, tablets were subjected for evaluation of hardness, friability, drug content uniformity. Preliminary evaluation of granules showed that, 0.71 to 0.77 mm granule size, 29.20 to 30.10° angles of repose and 22.1 to 12.7% fines. Hardness was found in the range of 7.1 to 7.4 kg cm-2, the percent friability was in the range of 1.50 to 0.75%. The tablet showed 97.46 to 98.96% of labeled amount of paracetamol indicating uniformity in drug content, 8 to 18 min disintegration time and more than 90% dissolution in 75 min. Tablets at 6% w/w binder concentration showed more optimum results as tablet binder. The Aegle marmelos gum was found to be useful for the preparation of uncoated tablet dosage form.
Patkar Atul N,Desai Nilesh V,Ranage Akkatai A,Kalekar Kamlakar S
International Research Journal of Pharmacy , 2012,
Abstract: Since time immemorial, plants and their products have been the primary resource of food and medicines for mankind. Aegle marmelos commonly known as bael (or bel), belonging to the family Rutaceae, is a moderate sized, slender and aromatic tree. A number of chemical constituents and various therapeutic effects of leaves of Aegle marmelos have been reported by different workers. Extensive investigations have been carried out on different parts of Aegle marmelos and as a consequence, varied classes of compound viz., alkaloids, coumarins, terpenoids, fatty acids and amino acids have been isolated from its different parts. Various phytochemical, ethnobotanical and pharmacological evaluations have been reported in this literature for the important potential of the Aegle marmelos.
Ashoka M. Shenoy*, Rajnikant Singh, Rajan Moses Samuel, R. Yedle and A.R. Shabraya
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: The objective of present study is to evaluate the anti ulcer activity of methanolic extract of leaves of Aegle marmelos. The cause of ulceration in patients is mainly due to hypersecretion of gastric juice and pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. The anti-ulcer activity of methanolic extract of Aegle marmelos leaves was investigated by aspirin plus pylorus ligation induced gastric ulcer in rats, Indomethacin induced ulcer in rats, water immersion stress test induced ulcer in rats. In aspirin plus pylorus ligation model, Aegle Marmelos at doses of 200 and 400 mg/kg produced significant reduction in gastric volume, free acidity and ulcer index compared to control. In Indomethacin and water immersion stress test induced ulcer models both doses (200mg/kg & 400mg/kg) of Aegle marmelos extract significantly reduced severity of ulceration. This present study indicates Aegle marmelos leaves extract have potential anti ulcer activity.
Patel Axay R,Garach Dipak,Chakraborty Manodeep,Kamath Jagdish V.
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: Traditional system of medicine consist large number medicinal plants, which conveyed their potential therapeutic utilities. Aegle marmelos (Linn.) is commonly known as Bael belongs to Rutaceae Family, widely grown in India, Tropical and subtropical Countries. In India, Aegle marmelos (Linn.) possess great mythological significance and medicinal significant in ancient system of medicine as well. Number of studies on photochemistry of the plat suggest no of bioactive chemical entity like, γ-sitosterol, aegelin, lupeol, rutin, marmesinin, β-sitosterol, flavone, glycoside, O-isopentenyl halfordiol, marmeline and phenylethyl cinnamamides. A priceless tank of bioactive molecule of the plant exploit its medicinal properties such as antidiabetic, antiulcer, antioxidant, antimalarial, anti-inflammatory, anticancer, radioprotective, antihyperlipidaemic, antifungal, antibacterial and antiviral activities. Present review highlights the present Ethno-pharmacological uses, and chemical properties of Aegle marmelos (Linn.)
Antistress, Adoptogenic Activity Of Aegle marmelos Fruit In Mice  [cached]
Meera Sumanth,Mustafa S S
Pharmaceutical Reviews , 2005,
Abstract: Ethanolic extract of unripe fruits of Aegle marmelos was tested for antistress, adoptogenic activity in mice using swim endurance test and cold restrain stress. The extract exhibited significant antistress, adoptogenic activity by improving the swim duration and reducing the elevated WBC, blood glucose and plasma cartisone. Acute toxicity studies revealed that LD50 is more than a dose of 3 g/kg body weightIntroductionAn Adaptogen increases the power of resistance against physical, chemical or biological noxious agents; it has a normalizing influence on body. The mode of action of adoptogens is basically associated with the stress system Adoptogens increase the capacity of stress system to respond to external signals at the higher level of the equilibrium of activating and deactivating mediators of stress response. The plant Adoptogen is defined as “Smooth pro-stressors which reduce reactivity of host defense systems and decrease damaging effects of various stressors due to increased basal level of mediators involved in the stress response” (Panossian et al.,1999). A number of plants possess adoptogenic activity due to diverse classes of chemical compounds.
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