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Translational Medicine is developing in China: A new venue for collaboration
Xiangdong Wang, Ena Wang, Francesco M Marincola
Journal of Translational Medicine , 2011, DOI: 10.1186/1479-5876-9-3
Abstract: Translational Medicine is an emerging area comprising multidisciplinary Research from basic sciences to medical applications well summarized by the Bench-to-Beside concept; this entails close collaboration between clinicians and basic scientists across institutes. We further clarified that Translational Medicine should be regarded as a two-way road: Bench-to-Bedside and Bedside-to-Bench [1], to complement testing of novel therapeutic strategies in humans with feedback understanding of how human react to the treatment. It is, therefore, critical and important to define and promote Translational Medicine among clinicians, basic Researchers, biotechnologists, politicians, ethicists, sociologists, investors and coordinate these efforts among different Countries [2] fostering aspects germane only to this type of Research such as, as recently discussed, biotechnology entrepreneurship [3]. Moreover, the recognized need to base biomedical discoveries on knowledge derived from human samples should be covered by the development of high quality Biobanks [4] and tools for data mining of existing information [5]. Translational Medicine as an inter-disciplinary science is developing rapidly and widely and, in this article, we will place a special emphasis on China.A first National step toward the promotion of Translational Medicine in China was to hold the first Symposium on Translational Medicine in 2007. Another milestone emphasizing the commitment of this Country to the rapid development of Translational Medicine was the Sino-America Symposium on Clinical and Translational Research co-organized by the GlobalMD Organization, Chinese Academy of Medical Sciences and the U.S. National Institutes of Health Clinical Center in June of 2010 [6]. The meeting aimed at gathering clinicians, Researchers, ethicists and health care officials from hospitals, academia and governmental agencies, involved in human subject Research, multi-national clinical trials, and Translational "bench-to-bed
The Excellence in Translational Medicine Award 2006–07
Richard J Ablin, Yi-Xin Zeng
Journal of Translational Medicine , 2007, DOI: 10.1186/1479-5876-5-40
Abstract: In our endeavor to recognize outstanding contributions in the field of translational medicine, the Editorial Board of the Journal of Translational Medicine (JTM) established "The Excellence in Translational Medicine Award" in May 2006 [1].The recipient of "The Excellence in Translational Medicine Award" will receive a $2,500 prize sponsored by Global Translational Medicine, Pfizer Global Research and Development to cover expenses for any meeting sponsored by a non-for-profit organization that is relevant to the goal of translational medicine and research.Fifteen nominated papers from investigators representative of eight countries covering a wide range of disciplines published in JTM between 1 July 2006 – 30 June 2007 were evaluated. For this purpose, an Award Committee* comprised of ten members of the Editorial Board selected and co-chaired by Richard J. Ablin (University of Arizona College of Medicine and the Arizona Cancer Center, Tucson, AZ) and Yi-Xin Zeng (Sun Yat-sen University Cancer Center, Guangzhou, China) was formed. The National Institutes of Health Scoring System of 1–5, with 1 = Outstanding and 5 = Poor were used with the papers being evaluated with regard to their:? Scientific merit? Originality? Clarity? Relevance to the purposes of translational medicine and research? Research design? MethodologyThe competition, judged from the closeness of the scores, wherein 10 of the 15 papers evaluated were separated by ≤1 point and the top 4 papers by ≤0.4 points, was "fierce." The best score and winner of the "Excellence in Translational Medicine Award" was Xinmei Zhu and colleagues from the University of Pittsburgh School of Medicine; Pittsburgh Cancer Center; Geneva University and Oncovir for the paper entitled: "Toll-like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models" [2].Exemplifying the criteria for the "Excellence in Translational Medicine Award," Zhu e
Biomedical informatics and translational medicine
Indra Sarkar
Journal of Translational Medicine , 2010, DOI: 10.1186/1479-5876-8-22
Abstract: Biomedical informatics, by definition[1-8], incorporates a core set of methodologies that are applicable for managing data, information, and knowledge across the translational medicine continuum, from bench biology to clinical care and research to public health. To this end, biomedical informatics encompasses a wide range of domain specific methodologies. In the present discourse, the specific aspects of biomedical informatics that are of direct relevance to translational medicine are: (1) bioinformatics; (2) imaging informatics; (3) clinical informatics; and, (4) public health informatics. These support the transfer and integration of knowledge across the major realms of translational medicine, from molecules to populations. A partnership between biomedical informatics and translational medicine promises the betterment of patient care[9,10] through development of new and better understood interventions used effectively in clinics as well as development of more informed policies and clinical guidelines.The ultimate goal of translational medicine is the development of new treatments and insights towards the improvement of health across populations[11]. The first step in this process is the identification of what interventions might be worthy to consider[12]. Next, directed evaluations (e.g., randomized controlled trials) are used to identify the efficacy of the intervention and to provide further insights into why a proposed intervention works[12]. Finally, the ultimate success of an intervention is the identification of how it can be appropriately scaled and applied to an entire population[12]. The various contexts presented across the translational medicine spectrum enable a "grounding" of biomedical informatics approaches by providing specific scenarios where knowledge management and integration approaches are needed. Between each of these steps, translational barriers are comprised of the challenges associated with the translation of innovations developed through
Translational medicine and the human microbiome
Rob Knight
Genome Biology , 2010, DOI: 10.1186/gb-2010-11-s1-i15
Abstract: Here I discuss the variation in the human microbiome within and between people, with a focus on the importance of spatially and temporally resolved studies, and the use of animal models, to gain insight into the role of microbes in obesity. Interestingly, many features of the microbiota of humans can be transferred into mice. The prospects for building a translational medicine pipeline, in which a single stool sample can be used to predict which interventions will work for which person, are compelling.
Implementations of translational medicine
Kai-Christian Sonntag
Journal of Translational Medicine , 2005, DOI: 10.1186/1479-5876-3-33
Abstract: The rapid evolutions in science have generated a tremendous spectrum of new technologies and tools in both basic and clinical research/medicine. This includes the constant improvement of old and the discovery of new diagnostics and therapies, which increasingly contain and integrate elements from different fields, such as biomedical and other sciences, modern and traditional medicine and various technology branches. In addition, the application of these developments in clinical settings have created a "feed-back-loop" providing crucial information about their feasibility and success in improving human health. This network of scientific and clinical research/medicine has become one of the factors in shaping modern societies not only by being a major economical factor (see [1] for details), but also by challenging basic values and traditional thinking. To face the emerging challenges of creating a balanced and effective healthcare system, new concepts are needed for providing a framework of integrative strategies and solutions that efficiently combine basic and clinical research/medicine.So far, translational research/medicine has rather been a linear concept rooted in traditional (academic) approaches to provide therapies for diseases (from bench to bedside), while paying little attention to patient-oriented research that involves understanding the underlying cause of disease and its treatments (from bedside to bench). Moreover, not much attention has been paid to many socio-economical aspects that are associated with research or medicine. Therefore, new definitions based on a bi- or multi-directional understanding of translational research/medicine have been proposed [2-5] and, recently, a strategic outline to successfully implement the goals of this new concept has been outlined in an article by H?rig et al. in Nature Medicine [1].This commentary aims to add a few additional aspects by emphasizing two major factors that strongly influence and, in turn, are influenc
Tumor biobanks in translational medicine  [cached]
Botti Gerardo,Franco Renato,Cantile Monica,Ciliberto Gennaro
Journal of Translational Medicine , 2012, DOI: 10.1186/1479-5876-10-204
Abstract: The concept of tissue banking as a “bio-repository” aimed to collection, storing and distribution of human biological material and clinical information, is emerging as a successful strategy to support clinical and translational research. In particular, Tumor Biobanks represent a key resource for diagnosis, research and experimental therapies, especially for those correlated to clinical application of a new type of medicine known as “intelligent drugs”. Biobanks are not “spontaneous” collections, but they needs an institutional organization, basically a research unit, whose effectiveness and quality can be guaranteed only if it is carefully organized according to precise and shared rules.
Translational Medicine and Modernization of Traditional Chinese Medicine

Xiao Hongbin,Liu Yanqiu,

世界科学技术-中医药现代化 , 2011,
Abstract: Translational medicine is a new subject that focuses on the transition process of developing and delivering basic theoretical and technological tools to assist prevention, diagnosis, and treatment of diseases. Translational medicine is regarded as a double-way route: Bench to Bedside and Bedside to Bench (BtoB). Traditional Chinese medicine (TCM), as a predominant industry in China, is undergoing the modernized progress from traditional Chinese herbs to Chinese medicine innovation. During the process, inheritance and innovation of TCM as well as the combination of basic research and clinical research are emphasized. The concept of inheritance, innovation and combination is closely related to the BtoB mode of translational medicine. Guided by TCM theories and characteristics of integrated multi-component regulation, the strategy of combining reduction with integration will further promote the modernization of TCM and new drug innovation.
Lost in Translation: Obstacles to Translational Medicine
Stacey P Mankoff, Christian Brander, Soldano Ferrone, Francesco M Marincola
Journal of Translational Medicine , 2004, DOI: 10.1186/1479-5876-2-14
Abstract: In addressing issues for Translational Medicine, we categorize the hurdles faced by our colleagues as follows:What's in a name? A name defines a concept which in turn may shape a vision. Therefore, it may behoove us to establish a common understanding of the definition of "translational medicine" to frame our expectations or frustrations. For most, "translational medicine" (or "translational research") describes a uni-directional effort to test in humans novel therapeutic strategies developed through experimentation. This would suffice if animal or other experimental models were representative of human pathology, but this remains to be determined [8-10]. as well summarized by Herbert Slade's: "there are no good animal models, but some are useful." In addition, translational medicine may include the development of new devices or novel diagnostic tools. Moreover, we suggested in a previous editorial that "translational medicine" is a two-way street where the drive to cure should be complemented by the pursuit to understand human diseases and their complexities [11]. Thus, one important aspect of translational medicine is going back from the bedside to the laboratory with observations made in human studies. This practice might be more constructive, focusing scientific thinking and providing more practical information.Mario Sznol, a member of JTM Editorial Board, suggested that Translational Medicine should be defined as a discipline that encompasses:1. Basic science studies which define the biological effects of therapeutics in humans2. Investigations in humans which define the biology of disease and provide the scientific foundation for development of new or improved therapies for human disease3. Non-human or non-clinical studies conducted with the intent to advance therapies to the clinic or to develop principles for application of therapeutics to human disease4. Any clinical trial of a therapythat was initiated based on #1–3 with any endpoint including toxicity and/
AAAS joins the Translational Medicine family
Christian Brander, Francesco M Marincola
Journal of Translational Medicine , 2009, DOI: 10.1186/1479-5876-7-32
Abstract: It has been almost six years since we launched the Journal of Translational Medicine as an open-access journal with Biomed Central [1]. At the beginning, we faced the inevitable skepticism and received several inquires among others also from Science reporters questioning both the significance of translational medicine in today's biomedical world and the need for a new journal dedicated to it.Some suggested that translational medicine (aka translational research/translational science) was a fad: a term fabricated to divert support from the basic sciences on the one hand and/or from clinical research on the other and, even more critical, a synonym for scientific investigations of lower quality that tried to excuse the supposed lack of scientific rigor with inherit disadvantages and limitations often not encountered for instance in studies using small laboratory animals.We however argued that although bridging the gap between discovery and clinical application was not an intrinsically novel concept – it does after all represent the long term goal of most scientists and clinicians – the value in identifying it as a distinct field was largely in enhancing the effectiveness of methods to efficiently transfer knowledge from the bench to the bedside, and, importantly, from the bedside to the bench [2-4]. In particular, we suggested that "the traditional goals of biomedical research function as a substrate for the catalytic activity of translational research that, like an enzyme, is aimed at enhancing the efficiency rather than modifying the process" [3].We also argued, in response to editors and publishers of existing journals who questioned the need for yet another one, that JTM would uniquely advance translational medicine through:1) Open access – Thanks to the partnership and vision of BioMed Central, information is divulged rapidly, broadly and without barriers to create an interactive platform for scientists, clinicians, patients, funding agencies and regulatory agenci
Bridging the translation gap and building the translation platform: translational medicine at Peking Union Medical College Hospital
Jun Xu,ShaoJing Liu,XueZhong Yu
Science China Life Sciences , 2013, DOI: 10.1007/s11427-012-4363-2
Abstract: Translational medicine is a fashionable term describing the inclination of basic science and clinical researchers to ultimately help patients through facilitating the incorporation of basic research findings into clinical practice. The development of translational medicine in recent years has been rapid—focusing on a new medical research model advocating “patient-centered” clinical work. Starting with clinical questions regarding patient problems, conducting basic research, and then turning the results of basic research quickly into clinical applications to improve clinical care is the heart of this new model. In this article, we examine the incorporation of and experience with translational medicine at Peking Union Medical College Hospital (PUMCH) in Beijing, China.
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