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Many faces of cutaneous leishmaniasis  [cached]
Bari Arfan Ul,Rahman Simeen
Indian Journal of Dermatology, Venereology and Leprology , 2008,
Abstract: Background: Cutaneous leishmaniasis (CL) is known for its clinical diversity and increasing numbers of new and rare variants of the disease are being reported these days. Aim: The aim of this descriptive study was to look for and report the atypical presentations of this common disease occurring in Pakistan. Methods: The study was carried out in three hospitals (MH, Rawalpindi; PAF Hospital, Sargodha; and CMH, Muzaffarabad) from 2002 to 2006. Military and civilian patients of all ages, both males and females, belonging to central and north Punjab province and Kashmir were included in the study. Clinical as well as parasitological features of cutaneous leishmaniasis were studied. The unusual lesions were photographed and categorized accordingly using simple descriptive statistics. Results: Out of 718 patients of cutaneous leishmaniasis, 41 (5.7%) had unusual presentations. The commonest among unusual morphologies was lupoid leishmaniasis 14 (34.1%), followed by sporotrichoid 5 (12.1%), paronychial 3 (7.3%), lid leishmaniasis 2 (4.9%), psoriasiform 2 (4.9%), mycetoma-like 2 (4.9%), erysipeloid 2 (4.9%), chancriform 2 (4.9%), whitlow 1 (2.4%), scar leishmaniasis 1 (2.4%), DLE-like 1 (2.4%), ′squamous cell carcinoma′-like 1 (2.4%), zosteriform 1 (2.4%), eczematous 1 (2.4%), verrucous 1 (2.4%), palmar/plantar 1 (2.4%) and mucocutaneous 1 (2.4%). Conclusion: In Pakistan, an endemic country for CL, the possibility of CL should be kept in mind while diagnosing common dermatological diseases like erysipelas, chronic eczema, herpes zoster, paronychia; and uncommon disorders like lupus vulgaris, squamous cell carcinoma, sporotrichosis, mycetoma and other deep mycoses.
Centrally symmetric polytopes with many faces  [PDF]
Alexander Barvinok,Seung Jin Lee,Isabella Novik
Mathematics , 2011,
Abstract: We present explicit constructions of centrally symmetric polytopes with many faces: first, we construct a d-dimensional centrally symmetric polytope P with about (1.316)^d vertices such that every pair of non-antipodal vertices of P spans an edge of P, second, for an integer k>1, we construct a d-dimensional centrally symmetric polytope P of an arbitrarily high dimension d and with an arbitrarily large number N of vertices such that for some 0 < delta_k < 1 at least (1-delta_k^d) {N choose k} k-subsets of the set of vertices span faces of P, and third, for an integer k>1 and a>0, we construct a centrally symmetric polytope Q with an arbitrary large number N of vertices and of dimension d=k^{1+o(1)} such that least (1 - k^{-a}){N choose k} k-subsets of the set of vertices span faces of Q.
The many faces of depression in primary care
Hegadoren, Kathy;Norris, Colleen;Lasiuk, Gerri;Silva, Denise Guerreiro Vieira da;Chivers-Wilson, Kaitlin;
Texto & Contexto - Enfermagem , 2009, DOI: 10.1590/S0104-07072009000100019
Abstract: depression is a serious global health problem. it creates a huge economic burden on society and on families and has serious and pervasive health impacts on the individual and their families. specialized psychiatric services are often scarce and thus the bulk of care delivery for depression has fallen to primary care providers, including advanced practice nurses and experienced nurses who work in under-serviced regions. these health professionals require advanced knowledge about the many faces that depression can display. this article reviews some of the faces of depression seen by primary care providers in their practices. considering depression as a heterogeneous spectrum disorder requires attention to both the details of the clinical presentation, as well as contextual factors. recommendations around engagement and potential interventions will also be discussed, in terms of the client population as well as for the practitioner who may be isolated by geography or discipline.
The many faces of optimism - Extended version  [PDF]
István Szita,András L?rincz
Computer Science , 2008,
Abstract: The exploration-exploitation dilemma has been an intriguing and unsolved problem within the framework of reinforcement learning. "Optimism in the face of uncertainty" and model building play central roles in advanced exploration methods. Here, we integrate several concepts and obtain a fast and simple algorithm. We show that the proposed algorithm finds a near-optimal policy in polynomial time, and give experimental evidence that it is robust and efficient compared to its ascendants.
“Normality”: concept of how many faces?
Cláudia Rodrigues de Freitas
Revista Educa??o Especial , 2012,
Abstract: This paper is intended to analyze how the concept of “normality”, divided in normal and abnormal, has been taking shape in our time, based on Canguilhem’s and Foucault’s views. By analyzing the theory, I recognize evidence of a process of biologization of life which revisits itself and takes new shapes over the last years through the process of medicalization. Medicalization is the current controlling device and cannot be boiled down to prescribing medication, but we can also think of it as a gear, as a machine that transforms life into objects. As evidence of this analysis, a school situation intended to illustrate the concepts addressed is presented. The aforementioned situation was observed at the Municipal School System of Porto Alegre. Scholastic discourse generates different ways of acting and living in the school, but is it intended to do so?
The Desire for Connection—Shame and its Many Faces  [cached]
Mary Zournazi
Cultural Studies Review , 2011,
Abstract: A review of Elspeth Probyn, Blush: Faces of Shame (University of New South Wales Press, Sydney, 2005).
The Many Faces of Wnt and Pancreatic Ductal?Adenocarcinoma Oncogenesis  [PDF]
Colin D. Weekes,Robert A. Winn
Cancers , 2011, DOI: 10.3390/cancers3033676
Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains amongst the most lethal human cancers. PDAC is characterized by the tumor mass containing a paucity of malignant cells in association with a large desmoplastic reaction comprised of a variety of stromal components. Sporadic PDAC oncogenesis occurs as a result of the sequential acquisition of genetic aberrations occurring in core genetic pathways. Unfortunately, the average PDAC contains a large number of genetic aberrations that are not uniform between individual cancers. The interplay between the complex genetics and stromal component may represent a significant barrier to the development of effective therapy for this disease and ultimately be an important factor in PDAC lethality. The Wnt pathway has been identified as a one of the common pathways undergoing genetic alterations in PDAC. Wnt is a complex signal transduction pathway utilizing both a b-catenin dependent (canonical) and b-catenin independent (noncanonical) signals to affect a wide array of intracellular events. Wnt signal transduction is an integral component of pancreas organogenesis promoting the expansion and development of the exocrine pancreas. Pancreatic cancer may utilize the Wnt signaling pathway in concert with other signaling pathways such as notch during tumorigenesis. This review will focus on the role of Wnt signal transduction in pancreatic cancer biology.
The Many Faces of Neuroendocrine Differentiation in Prostate Cancer Progression  [PDF]
Stéphane Terry,Himisha Beltran
Frontiers in Oncology , 2014, DOI: 10.3389/fonc.2014.00060
Abstract: In normal prostate, neuroendocrine (NE) cells are rare and interspersed among the epithelium. These cells are believed to provide trophic signals to epithelial cell populations through the secretion of an abundance of neuropeptides that can diffuse to influence surrounding cells. In the setting of prostate cancer (PC), NE cells can also stimulate surrounding prostate adenocarcinoma cell growth, but in some cases adenocarcinoma cells themselves acquire NE characteristics. This epithelial plasticity is associated with decreased androgen receptor (AR) signaling and the accumulation of neuronal and stem cell characteristics. Transformation to an NE phenotype is one proposed mechanism of resistance to contemporary AR-targeted treatments, is associated with poor prognosis, and thought to represent up to 25% of lethal PCs. Importantly, the advent of high-throughput technologies has started to provide clues for understanding the complex molecular profiles of tumors exhibiting NE differentiation. Here, we discuss these recent advances, the multifaceted manner by which an NE-like state may arise during the different stages of disease progression, and the potential benefit of this knowledge for the management of patients with advanced PC.
The Many Faces of Protein–Protein Interactions: A Compendium of Interface Geometry  [PDF]
Wan Kyu Kim,Andreas Henschel,Christof Winter,Michael Schroeder
PLOS Computational Biology , 2006, DOI: 10.1371/journal.pcbi.0020124
Abstract: A systematic classification of protein–protein interfaces is a valuable resource for understanding the principles of molecular recognition and for modelling protein complexes. Here, we present a classification of domain interfaces according to their geometry. Our new algorithm uses a hybrid approach of both sequential and structural features. The accuracy is evaluated on a hand-curated dataset of 416 interfaces. Our hybrid procedure achieves 83% precision and 95% recall, which improves the earlier sequence-based method by 5% on both terms. We classify virtually all domain interfaces of known structure, which results in nearly 6,000 distinct types of interfaces. In 40% of the cases, the interacting domain families associate in multiple orientations, suggesting that all the possible binding orientations need to be explored for modelling multidomain proteins and protein complexes. In general, hub proteins are shown to use distinct surface regions (multiple faces) for interactions with different partners. Our classification provides a convenient framework to query genuine gene fusion, which conserves binding orientation in both fused and separate forms. The result suggests that the binding orientations are not conserved in at least one-third of the gene fusion cases detected by a conventional sequence similarity search. We show that any evolutionary analysis on interfaces can be skewed by multiple binding orientations and multiple interaction partners. The taxonomic distribution of interface types suggests that ancient interfaces common to the three major kingdoms of life are enriched by symmetric homodimers. The classification results are online at http://www.scoppi.org.
The blind men see the elephant-the many faces of fatty liver disease  [cached]
Madhusudana Girija Sanal
World Journal of Gastroenterology , 2008,
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a group of diseases with excess fat in liver in the absence of a poorly defined limit of alcohol consumption. Most common variety, a universal public health problem, is associated with insulin resistance caused by a host of genetic and epigenetic defects modulated by life style and environmental factors. In fact the term NAFLD is loose to incorporate so many etiologies except alcoholism and few other etiologies, presenting as fat in liver. However as a sign fatty liver is very important in predicting the risk of diabetes, cardiovascular disease, stroke, cirrhosis and cancer. Abnormal fat accumulation can result from several defects in nuclear receptors associated with lipid sensing, synthesis and oxidation like LXR, FXR, SREBP, ChREBP and PPAR; defects in the lipid influx-efflux channels, insulin signaling, proteins involved in fatty acid catabolism, defects in adipose tissue development and function, inappropriate nutrition and finally defects in neural regulatory mechanisms. The progress of the disease is determined by the basic defects which results in fat accumulation, an individual’s immunological response to the accumulated fat and its derivatives and the oxidant stress response. Congregation of unrelated genetic defects under same diagnosis ‘NAFLD’ can result in inefficient patient management. Further studies are required to understand the molecular basis of fatty liver to enable a personalized management of diseases presenting as fatty liver in the absence of alcohol abuse.
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