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Evaluación de la Efectividad Terapéutica y Tolerabilidad del Sulglicotide (Demucine ) en Pacientes con Gastritis Erosivas Crónicas y Duodenitis no Erosiva (S199)
M González,T Belandria,Y Jiménez,Y Méndez
Archivos Venezolanos de Farmacología y Terapéutica , 2001,
Abstract: Se evaluó la efectividad e inocuidad de Sulglicotide a la dosis de 200 mg tres veces al día durante 6 semanas en 62 pacientes con gastritis y duodenitis no ulcerosa. Las evaluaciones fueron realizadas mediante examen clínico, endoscopia y opinión por parte del médico. A la sexta semana el tratamiento produjo una disminución significativa de los escores iniciales de todos los síntomas evaluados, así como en los escores endoscópicos. Los efectos adversos observados fueron: náuseas, resequedad, mal sabor y olor en la boca, cefalea, erupciones de la piel, mareos y sensación de hambre. We evaluated effectivity and inocuity of Sulglicotide, at dosis 200 mg three time for day for 6 weeks, in patients with diagnostic of gastritis and duodenits no ulcer.The evaluation were make through clinical, endoscopic exam, and medical opinion. The initial score for all symptom and endoscopic score lowed significantly at 6th week. The effects adverses were nauseas, mouth dry, halitosis, bad taste, headeche, rash, dizzines and hungry sensation.
Evaluación de la Efectividad Terapéutica y Tolerabilidad del Sulglicotide (Demucine?) en Pacientes con Gastritis Erosivas Crónicas y Duodenitis no Erosiva (S199)
González,M; Belandria,T; Jiménez,Y; Méndez,Y; Montiel,J; Matos,C; Hinestroza,R; Esaa,C; Castillo,J; Villasmil,L; Tovar,M; Pe?aloza,O; León,S; D?arthena,D; Bombala,I; Rivas,H; Sulbarán,M; Balabú,M; Moricha,J;
Archivos Venezolanos de Farmacología y Terapéutica , 2001,
Abstract: we evaluated effectivity and inocuity of sulglicotide, at dosis 200 mg three time for day for 6 weeks, in patients with diagnostic of gastritis and duodenits no ulcer.the evaluation were make through clinical, endoscopic exam, and medical opinion. the initial score for all symptom and endoscopic score lowed significantly at 6th week. the effects adverses were nauseas, mouth dry, halitosis, bad taste, headeche, rash, dizzines and hungry sensation.
Efecto protector del Lactobacillus acidophilus en gastritis erosiva inducida por indometacina en ratones  [cached]
Ana María Nageli Lazo Ramos,Miguel Maco,Zulia Matos,Yolanda Magui?a
CIMEL. Ciencia e Investigación Médica Estudiantil Latinoamericana , 2007,
Abstract: Objetivo: determinar el efecto protector del Lactobacillus acidophilus en la prevención de gastritis erosiva inducida por indometacina. Dise o: estudio experimental. Lugar: Laboratorio de Investigación del Departamento de Farmacología de la Universidad Nacional Federico Villarreal. Materiales: ratones de la especie Mus musculus Balb/c/CNPB, cepa de Lactobacillus acidophilus. Intervenciones: administración de Lactobacillus acidophilus a dosis alta (0,06 mg/ml) y dosis baja (0,03 mg/ml) en la primera etapa; y dosis ulcerogénica de indometacina (1,32 mg/ml) en la segunda etapa. Principales medidas de resultados: sistema Sydney de clasificación de las gastritis según aspectos histológicos. Resultados: a dosis baja de Lactobacillus acidophilus, el 62,5 % presentó gastritis erosiva de forma leve y gastritis moderada en un 37,5 %. A dosis alta de Lactobacillus acidophilus, gastritis moderada y grave, en 37,5 y 62,5% respectivamente. En el grupo control todos lo ratones presentaron gastritis moderada. Conclusiones: La administración de Lactobacillus acidophilus en dosis de 15 mg/kg de peso, ejerce efectos de protección sobre la mucosa gástrica, en la gastritis erosiva por administración de indometacina y en dosis de 30 mg/kg de peso, ejerce efectos tóxicos sobre la mucosa gástrica, promoviendo la presentación de una gastritis erosiva grave
Magnetoterapia en pacientes con gastritis crónica antral Magnetotherapy in patients with chronic antral gastritis
Marvelis Domínguez Iglesias,Zoila Pérez Rodríguez
Revista Cubana de Medicina Militar , 2012,
Abstract: Introducción: la gastritis crónica es una de las 40 enfermedades más frecuentes en Cuba, su etiología es multifactorial y el Helicobacter pylori es el agente causal principal. A los campos magnéticos se le reconocen los efectos antiinflamatorios, analgésico, regenerador de tejidos e inhibidor del desarrollo de gérmenes patógenos. Objetivo: evaluar la utilidad de la magnetoterapia en pacientes con gastritis crónica antral. Métodos: se realizó un estudio cuasi-experimental prospectivo en 30 pacientes, con diagnóstico positivo histológico de gastritis crónica antral. Todos los pacientes recibieron como único tratamiento campo magnético, frecuencia 50 Hz, en región epigástrica en 20 sesiones. Antes y después del tratamiento se tuvo en cuenta evolución de los síntomas, estudio endoscópico con biopsia y la presencia de H. pylori (grado de colonización). Resultados: al finalizar el tratamiento, 22 pacientes (73,3 %) tenían mejoría clínica, en 26 (86,7 %) la gastritis estaba inactiva y en 23 (76,7 %) el grado de severidad de la gastritis fue ligero. Todos los pacientes colonizados por H. pylori tenían un grado ligero. Conclusiones: se considera que la magnetoterapia resulta útil en el tratamiento de la gastritis crónica antral. Introduction: chronic gastritis is among the 40 most common diseases in Cuba. Its etiology is multifactorial, Helicobacter pylori being the main causal agent. Magnetic fields are known to have antiinflammatory, analgesic and tissue regenerating properties, as well as a capacity to inhibit the development of pathogenic germs. Objective: evaluate the usefulness of magnetotherapy in patients with chronic antral gastritis. Methods: a prospective quasi-experimental study was conducted of 30 patients with a positive histological diagnosis of chronic antral gastritis. All patients received 20 sessions of 50 Hz magnetotherapy on the epigastric area as the only treatment. Before and after the treatment, an endoscopic study with biopsy was performed, and observations were made of the evolution of symptoms and the presence of Helicobacter pylori (degree of colonization). Results: upon completion of the treatment, 22 patients (73.3 %) showed clinical improvement, in 26 (86.7 %) gastritis was inactive, and in 23 (76.7 %) the degree of severity of gastritis was slight. All patients colonized by Helicobacter pylori showed a slight degree. Conclusions: magnetotherapy is considered to be useful in the treatment of chronic antral gastritis.
Features of the Atrophic Corpus Mucosa in Three Cases of Autoimmune Gastritis Revealed by Magnifying Endoscopy
Kazuyoshi Yagi,Atsuo Nakamura,Atsuo Sekine,David Graham
Case Reports in Medicine , 2012, DOI: 10.1155/2012/368160
Abstract: Atrophic gastritis, whether caused by Helicobacter pylori infection or as a result of an autoimmune process, is associated with corpus atrophy. However, whereas atrophic gastritis caused by H. pylori involves the antrum, the antrum is spared in autoimmune gastritis. Here, we report the use of magnifying endoscopy to identify and distinguish atrophic gastritis caused by H. pylori from autoimmune gastritis. The mucosal pattern in autoimmune gastritis is that of closely arranged small round and oval pits, thus differing from the pattern seen in atrophic mucosa due to H. pylori infection. We speculate that this reflects differences in inflammation between the two types of gastritis. In autoimmune gastritis the inflammation is directed primarily against gastric glands, whereas in H. pylori infection the inflammation is directed against the bacteria on or near the surface and the damage initially affects the surface epithelium. During repair, the normal regular round pits are destroyed, whereas they remain largely intact in mucosa with autoimmune-associated atrophy. Confirmation of the features of autoimmune gastritis revealed by magnifying endoscopy would not only make the endoscopic diagnosis of autoimmune gastritis more accurate, but also help to elucidate changes in the surface epithelial structure of gastritis due to various causes.
Histological features of the gastric mucosa in children with primary bile reflux gastritis
Yanyi Zhang, Xi Yang, Weizhong Gu, Xiaoli Shu, Ting Zhang, Mizu Jiang
World Journal of Surgical Oncology , 2012, DOI: 10.1186/1477-7819-10-27
Abstract: The Bilitec 2000 was used for 24 h monitoring of gastric bile in 59 children with upper gastrointestinal symptoms. The histological characteristics of the gastric mucosa were examined and scored.Thirteen of the 59 patients had a helicobacter pylori infection and were excluded; therefore, 46 cases were included in this study. The positive rate of pathological duodenogastric reflux was significantly higher in patients with foveolar hyperplasia than those without foveolar hyperplasia; however, the rate was significantly lower in patients with vascular congestion than those without vascular congestion. The longest reflux time and the total percentage time of bile reflux were significantly lower in patients with vascular congestion than those without vascular congestion. A total of 9 types of histological changes were analyzed using a binary logistic regression. Foveolar hyperplasia and vascular congestion in the superficial layer became significant variables in the last step of the stepwise regression.Foveolar hyperplasia was associated with the severity of bile reflux, suggesting that it is a histological feature of primary BRG in children, while vascular congestion may be a protective factor.In addition to gastric acid and Helicobacter pylori (HP), bile reflux is one of the primary factors involved in the pathophysiological processes leading to gastric mucosal lesions in patients with chronic gastritis; however, little is known about the exact histological features of bile reflux and its contributions to gastric mucosal lesions in this disease [1,2]. When duodenal contents reflux into the stomach for a short period during a physiological event, it causes few symptoms. However, duodenogastric reflux (DGR) becomes pathological when it is excessive or lasts for an extended period of time. Bile reflux gastritis (BRG) is due to an excessive reflux of bile, pancreatic and intestinal secretions into the stomach. The increased bile reflux may cause increased gastric mucosal i
Niveles de vitamina B12 en pacientes colombianos con gastritis crónica atrófica Levels of vitamin B12 in colombian patients with chronic atrophic gastritis  [cached]
Julián David Martínez Marín,Sandra Consuelo Henao Riveros,Mario Humberto Rey Tovar
Revista Colombiana de Gastroenterologia , 2010,
Abstract: Se presenta un grupo de 75 pacientes adultos colombianos, con diagnóstico de gastritis crónica atrófica de acuerdo a los criterios de Sydney, de los cuales el 28% presentó deficiencia de vitamina B12 y al 9% se le diagnóstico anemia perniciosa. Las cifras de hemoglobina, volumen corpuscular medio no se correlacionaron con el déficit de vitamina B12. No se encontró una asociación estadística del déficit de la vitamina B12 con el género, edad mayor de 60 a os de los pacientes o con la presencia del Helicobacter pylori (H. pylori). La edad promedio de los pacientes con déficit de vitamina B12 o con anemia perniciosa es menor a la que tradicionalmente se reporta para estas enfermedades We present a group of 75 Colombian adults who were diagnosed with chronic atrophic gastritis in accordance with the Sydney criteria. 28% of the group had vitamin B12 deficiencies: 9% were diagnosed with Pernicious anemia. Hemoglobin and mean corpuscular volume were not correlated with vitamin B12 deficiency. We found no statistical association of vitamin B12 deficiency with gender, patients over 60 years of age, or the presence of Helicobacter pylori (H. pylori). The average age of patients with vitamin B12 deficiency or pernicious anemia is less than that traditionally reported for these diseases
Gastritis crónica. Correlación de la clasificación de Sydney con el diagnóstico endoscópico Chronic gastritis. Correlation of the Sydney classification with endoscopic diagnosis
Juan José Gaviria Jiménez,Mario Melguizo Bermúdez
Revista Colombiana de Cirugía , 2004,
Abstract: El concepto de gastritis crónica siempre ha sido motivo de controversia. Con el propósito de eliminar confusiones diagnósticas se crea en Sydney (Australia) un sistema de clasificación y gradación (Sistema Sydney). El presente estudio se propuso determinar la utilidad y reproducibilidad de este sistema para la gradación y clasificación de las gastritis crónicas y determinar la correlación endoscópica con la misma. La investigación se realizó en 55 pacientes sometidos a endoscopia digestiva alta y que tuvieron diagnóstico endoscópico de gastritis crónica. El estudio fue de tipo descriptivo, prospectivo y longitudinal. Con base en el Sistema Sydney, se hizo una clasificación de signos endoscópicos y se empleó una guía visual, propuesta también por el Sistema, para su lectura histopatológica. Todos los pacientes incluidos en el estudio con el diagnóstico de gastritis crónica fueron corroborados en estudio histopatológico como tal. El hallazgo endoscópico predominante fue el eritema en parches o en estrías de la mucosa, y estuvo presente en 98,2% de los pacientes. No hubo correlación endoscópica-histopatológica en lo que respecta al diagnóstico por regiones anatómicas (antral-antrocorporal) o en su gradación (niveles de severidad). Se encontraron relaciones importantes entre los signos endoscópicos de hiperplasia y nodularidad con la presencia de Helicobacter pylori, la existencia de metaplasia intestinal incompleta en la incisura angularis y la relación H. pylori-actividad (neutrófilos). Para unificar criterios de diagnóstico y lenguaje se recomienda el uso de la guía visual y se comprueba la utilidad y reproducibilidad del Sistema Sydney. The concept of chronic gastritis has always been controversial. With the aim of avoiding diagnostic confusions, a classification and grading system was established at a meeting held in Sidney (Australia). The objective of this study was determining the utility and possibility of reproduction of the Sidney System for grading and classifying chronic gastritis and determining its correlation with endoscopic diagnosis. The study included 55 patients submitted to upper gastrointestinal endoscopy and in whom the diagnosis of chronic gastritis was established; the study was descriptive, prospective, and longitudinal. A classification of the endoscopic findings based on the Sidney classification was used as visual guide, a classification which was also proposed for the histopathologic reading. The diagnosis of chronic gastritis was corroborated by histopathology in all patients. The predominant endoscopic finding was patchy eryt
Helicobacter pylori y estrés psicosocial en pacientes con gastritis crónica
José I. Monta?o,Ximena Dossman,Julián A. Herrera,Arnoldo Bromet
Colombia Médica , 2006,
Abstract: Objetivo: Determinar la prevalencia de Helicobacter pylori y el estrés psicosocial en pacientes con síntomas digestivos recidivantes y diagnóstico previo de gastritis crónica. Métodos: Se realizó un estudio piloto de casos y controles donde el grupo de estudio fueron pacientes con gastritis crónica e infección por H. pylori y el grupo control, enfermos con gastritis crónica sin infección. Los pacientes se evaluaron en el Hospital Universitario del Valle (HUV) y en la Fundación Clínica Valle del Lili (FVL) en Cali, Colombia durante el 2003. La infección por H. pylori se determinó por endoscopia digestiva y el estrés psicosocial mediante la Escala de Ansiedad y Depresión en el Hospital (HADS). Resultados: Se estudiaron 164 pacientes, 74 (45.1%) en el HUV y 90 (54.9%) en la FVL. Las características sociodemográficas del grupo en estudio y del control fueron comparables. Se observó infección por H. pylori en 113 (68.9%) pacientes y estrés psicosocial en 115 (70.1%). Los niveles de ansiedad fueron mayores que los de depresión (ansiedad mediana=9, rango 1-20; depresión mediana=6, rango 0-17) especialmente en el HUV (p=0.03). El estrés psicosocial no se asociaba con la infección por H. pylori (p=0.69). Conclusión: Los pacientes con diagnóstico endoscópico previo de gastritis crónica y síntomas digestivos recidivantes presentan una alta prevalencia de infección por H. pylori y estrés psicosocial sin estar asociados estos dos factores.
Immunoexpression of CD95 in chronic gastritis and gastric mucosa-associated lymphomas
Vassallo, J.;Godoy Jr., C.E.;Godoy, C.E.;Chagas, C.A.;Metze, K.;Trevisan, M.A.S.;
Brazilian Journal of Medical and Biological Research , 2004, DOI: 10.1590/S0100-879X2004000900015
Abstract: cd95 (fas/apo-1)-mediated apoptosis plays an important role in immunological regulation and is related to the pathogenesis of autoimmune diseases. immunoexpression of cd95 has been reported to frequently occur in low grade non-hodgkin lymphomas, especially of post-germinal center histogenesis, among which those originating in mucosa-associated lymphoid tissue (malt lymphomas). however, there is no report comparing in situ immunoexpression of this marker in lymphomas and the hyperplastic lymphoid reaction (chronic gastritis) related to helicobacter pylori infection. the purpose of the present research was to compare the intensity of lymphoid cd95 immunoexpression in 15 cases of h. pylori-related chronic gastritis and 15 gastric malt lymphomas. cd95 (anti-cd95) was detected by an immunoperoxidase technique in paraffin sections using the catalyzed amplification system. graduation of reaction intensity (percentage of cd95-positive cells) was semiquantitative, from 1+ to 4+. nine cases of chronic gastritis were 4+, five 2+ and one 1+. three lymphomas were 4+, three 3+, four 2+, four 1+, and one was negative. although 14 of 15 lymphomas were positive for cd95, the intensity of the reaction was significantly weaker compared to that obtained with gastric tissue for patients with gastritis (p = 0.03). the difference in cd95 immunoexpression does not seem to be useful as an isolated criterion in the differential diagnosis between chronic gastritis and malt lymphomas since there was overlapping of immunostaining patterns. however, it suggests the possibility of a pathogenetic role of this apoptosis-regulating protein in malt lymphomas.
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