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Primer caso de leucemia mieloide aguda tratado en Cuba con altas dosis de antraciclinas en la inducción First case of acute myeloid leukemia treated in Cuba using high doses of anthracycline in induction
Calixto Hernández Cruz,Aramís Nú?ez Quintana,Yusaima Rodríguez Fraga,José Carnot Uría
Revista Cubana de Medicina , 2012,
Abstract: La leucemia mieloide aguda abarca un heterógeneo espectro de enfermedades, de naturaleza maligna y clonal, que representan un reto formidable para la medicina moderna. Con la excepción de la leucemia promielocítica, los resultados terapéuticos alcanzados continúan siendo desalentadores. Recientemente han surgido datos que demuestran mejores resultados con el uso de altas dosis de antraciclinas en la inducción. Se presentó el primer caso en Cuba, en cuya inducción se utilizó la rubidomicina a 100 mg/m2 por 3 d, más el arabinósido de citosina a 100 mg/m2 por 7 d, ambos en infusión endovenosa continua. La evolución clínica es satisfactoria hasta el momento. Se revisó brevemente la literatura médica al respecto. The acute myeloid leukemia includes an heterogeneous spectrum of diseases of malignant and clonal origin representing a challenge of the current medicine. With the exception of the pro-myelocytic, the achieved therapeutical results continue being discouraging. Recently are available data demonstrating better results with the use of high doses of anthracycline in the induction. This is the first case in Cuba where in induction it was used the 100 mg/m2 rubidomicin plus 100 mg/m2 for three days plus 100 mg/m2 arabinoside for seven days, both in continuous intravenous infusion. The clinical course is satisfactory until now. Authors made a brief review of medical literature in this respect.
Bronquiolite obliterante com pneumonia em organiza o e aspergiloma em paciente com linfoma-leucemia de células T  [cached]
JHAYYA TERESA S.,PEREZ DOMINGO B.,LLARGES CELIA MALLART,FERREIRA RIMARCS G.
Jornal de Pneumologia , 2000,
Abstract: Há poucos relatos na literatura médica referentes à associa o de bronquiolite obliterante com pneumonia em organiza o (BOPO) e aspergiloma. Apresenta-se uma associa o de BOPO e aspergiloma pulmonar em uma paciente com linfoma-leucemia de células T do adulto. Sugere-se que os achados deste caso representam uma associa o fortuita e n o a express o de unidade nosológica.
Primer caso de leucemia mieloide aguda tratado en Cuba con altas dosis de antraciclinas en la inducción
Hernández Cruz,Calixto; Nú?ez Quintana,Aramís; Rodríguez Fraga,Yusaima; Carnot Uría,José; Chávez Medina,Raysel; Moya Pérez,Isbel;
Revista Cubana de Medicina , 2012,
Abstract: the acute myeloid leukemia includes an heterogeneous spectrum of diseases of malignant and clonal origin representing a challenge of the current medicine. with the exception of the pro-myelocytic, the achieved therapeutical results continue being discouraging. recently are available data demonstrating better results with the use of high doses of anthracycline in the induction. this is the first case in cuba where in induction it was used the 100 mg/m2 rubidomicin plus 100 mg/m2 for three days plus 100 mg/m2 arabinoside for seven days, both in continuous intravenous infusion. the clinical course is satisfactory until now. authors made a brief review of medical literature in this respect.
Leucemia/linfoma de células T do adulto
Bittencourt, Achiléa L.;Farré, Lourdes;
Anais Brasileiros de Dermatologia , 2008, DOI: 10.1590/S0365-05962008000400011
Abstract: adult t cell leukemia/lymphoma (atl) is an aggressive type of lymphoproliferative disease associated with the human t-cell lymphotropic virus type i (htlv-i) that is characterized by a short survival time and absence of response to chemotherapy. atl is classified into four clinical types: acute, chronic, lymphoma, and smoldering. another clinical form of atl, the primary cutaneous tumoral,with diverse characteristics, has been recently suggested. patients with acute, lymphoma and primary cutaneous tumoral types have a poor prognosis. the diagnostic criteria of atl consist of: positive serology for htlv-i; cytologic or histologic confirmation of cd4+/cd25+ t-cell leukemia/lymphoma; abnormal t lymphocytes in peripheral blood; and confirmation of monoclonal integration of htlv-i proviral dna. there is skin involvement in around 70% of atl cases, which could be primary (smoldering and primary cutaneous tumoral) or secondary. the skin lesions are multiple, erythroderma, papules and plaques being the most common. atl has no characteristic histological pattern, and may present patterns that could superimpose nonspecific peripheral t-cell lymphoma, mycosis fungoides or anaplastic large cell lymphoma. the immunohistochemistry pattern may also be similar to that of other t-cell lymphomas. thus, it is very important that in brazil htlv-i infection be investigated in all mature t-cell leukemias/lymphomas.
Linfoma/Leucemia de células T do adulto
Borducchi D.M.M.,Kerbauy J.,Oliveira J.S.R. de
Revista da Associa??o Médica Brasileira , 1999,
Abstract:
Primer trasplante cubano de ri ones pediátricos para un receptor adulto: Presentación de 1 caso
Antonio Enamorado Casanova,Gerardo Borroto Díaz,Carlos Guerrero Díaz,José Antonio Copo Jorge
Revista Cubana de Medicina , 2003,
Abstract: Se presentó el primer trasplante renal realizado en Cuba a un receptor adulto al cual se le injertaron ambos ri ones de un donante de 2 a os de edad fallecido por un trauma craneoencefálico; se expusieron los datos del trasplante así como la técnica de implante, inmunosupresión utilizada y la evolución clínica, humoral e imagenológica del postrasplante inmediato, que fue satisfactoria. Se tuvo en cuenta, además, un ingreso por enfermedad por citomegalovirus que complicó la evolución ulterior de la enferma, resuelto satisfactoriamente, así como el estado actual de la misma atendida en consulta externa. Se demostró que el doble trasplante renal de injertos procedentes de ni os a un receptor adulto constituye en nuestro medio una opción valedera para el tratamiento de enfermos con insuficiencia renal terminal. The first kidney transplantation performed in Cuba in an adult recipient that was implanted both kidneys from a 2-year-old donor who died of a cranioencephalic trauma was presented. Data of the transplantation as well as the technique of implant and the immunosupression used and the satisfactory clinical, humoral and imaging evolution of the immediate postransplant were explained. The admission of a female patient due to megalovirus that complicated her further evolution, its satisfactory solution, and the present state of the patient that is attended at the outpatient department were also taken into account. It was proved that the dual transplantation of pediatric kidneys into an adult recipient is a valid option for treating patients with end-stage kidney failure in our environment.
Leucemia linfoma T del adulto en Chile.: Estudio clínico-patológico y molecular de 26 pacientes
Cabrera C,M Elena; Labra G,Silvia; Meneses C,Pedro; Matutes,Estella; Cartier R,Luis; M Ford,Anthony; F Greaves,Melvyn;
Revista médica de Chile , 1999, DOI: 10.4067/S0034-98871999000800007
Abstract: background: adult t cell leukemia lymphoma is a lymphoproliferative syndrome etiologically associated to human t cell lymphotropic virus type i. aim: to describe the clinical and laboratory features of 26 caucasian chilean patients, with htlv-i positive adult t-cell leukemia lymphoma (atll). material and methods: diagnostic criteria included clinical features, cell morphology, immunophenotype, htlv-i serology and/or dna analysis by southern blot or pcr. results: according to the clinical presentation, 12 cases had the acute atll form, 6 had a lymphoma, 4 the chronic form and 4 had smoldering atll. the median presentation age was 50 years, younger than the japanese patients, but significantly older than patients from other south american countries (eg brasil, jamaica, colombia). the main clinical features: lymphadenopathy, skin lesions and hepatosplenomegaly, were similar in frequency to those of patients from other countries, except for the high incidence of associated neurological disease. tropical spastic paraparesis (tsp) in our series of atll, was seen in one third of the patients (8/26). a t-cell immunophenotype was shown in all 26 cases and htlv-i serology was positive in 25/26 patients. molecular analysis on the seronegative patient showed clonal integration of proviral htlv-i dna into the lymphocytes dna, and thus he may have been a poor responder to the retroviral infection. proviral dna integration was also demonstrated in 15/16 patients being clonal in 10, polyclonal in 3 (all smoldering cases) and oligoclonal in one. conclusions: atll in chile has similar clinical and laboratory features than the disease in other parts of the world, except for a younger age than japanese patients but older than those from other latin american countries and a high incidence of patients with associated tsp. detailed morphological and immunophenotypic analysis of the abnormal circulating lymphocytes, together with the documentation of htlv-i by serology and/or dna analysis
estatinas afectan la viabilidad de líneas celulares de leucemia y linfoma humanas in vitro
Mery Guerrero,Camilo Di Giulio,Juan Bautista De Sanctis
Revista de la Facultad de Medicina , 2010,
Abstract: Se ha propuesto que las estatinas inducen apoptosis sobre células tumorales. Para probar dicha hipótesis, se analizó el efecto de las estatinas atorvastatina, fluvastatina, lovastatina, mevastatina, pravastatina y simvastatina en el rango de concentraciones de 1 pM hasta 100 μM, sobre la viabilidad de las líneas celulares humanas Jurkat E6.1, Jurkat D1.1 (Linfoma T) , Daudi (Linfoma B), U937 (leucemia monocítica) y HL-60 (leucemia promielomonocítica) in vitro en cultivos de 48 horas, analizados por la técnica de hidrolización del compuesto bromuro de 3-(4,5-dimetiltiazol-2-il)-2,5-difenilltetrazolio (MTT). Lovastatina y mevastatina son los más potentes inductores de muerte celular independientemente del tipo celular (Ic 50 entre 12 y 50 μM). Para las otras estatinas se observan diferencias en el Ic50 según la línea celular atorvastatina (38,1 y 48,6 μM Jurkats, 55,3 μM Daudi y 100 μM para las otras líneas), pravastatina (25 μM HL-60, 55,6 y 60,7 μM Jurkats y ≥ 100 μM Daudi y U937), simvastatina (25,1 μM Jurkat D1.1, 50,2 μM Jurkat E6.1, 45,2 μM Daudi y 51,3 μM HL-60, y > 100 μM U937) y para fluvastatina en todos los casos > 100 μM. La disminución de la viabilidad celular se revierte completamente cuando las células son incubadas con 10 μM mevalonato. Se concluye que la lovastatina y mevastatina son las más potentes inductoras de muerte seguida por atorvastatina, pravastatina y simvastatina cuyo efecto depende del tipo de línea celular y la fluvastatina no tiene efectos importantes en la viabilidad de las líneas celulares estudiadas. Statins have been proposed to induce apoptosis of tumor cells. In order to test this hypothesis, the effect of atorvastatin, fluvastatin, lovastatin, mevastatin, pravastatin, simvastatin on cell viability was assessed by in vitro culture for 48 hr, at concentrations ranging from 1 pM to 100 μM on human cell lines Jurkat E6.1, Jurkat D1.1 (T cell lymphoma), Daudi (B cell lymphoma), U937 (monocitic leukemia) and HL-60 (pro mielomonocitic leukemia) and analyzed the oxidation of (3-(4.5-Dimethylthiazol-2-yl)-2.5- diphenyltetrazolium bromide (MTT). Lovastatin and mevastatin are the most potent inductors of cell death independently of the cell type (Ic 50 between 12 and 50 μM). Differences in the Ic50 are observed depending on the cell line: atorvastatina (38.1 and 48.6 μM Jurkats, 55.3 μM Daudi y 100 μM for the others lines), pravastatin (25 μM HL-60, 55.6 y 60.7 μM Jurkats and ≥ 100 μM Daudi and U937), simvastatin (25.1 μM Jurkat D1.1, 50.2 μM Jurkat E6.1, 45.2 μM Daudi and 51,3 μM HL-60, and > 100 μM U937) and for fluvastatin >
Primer reporte de Neisseria polysaccharea en Cuba  [cached]
Daymi Guzmán Hernández,Rafael Llanes Caballero,Isabel Martínez Motas,Eduardo A. Valdés Ramos
Revista Cubana de Medicina Tropical , 1999,
Abstract: En el Laboratorio Nacional de Referencia de Neisserias Patógenas del Instituto de Medicina Tropical "Pedro Kourí" se estudiaron 58 cepas identificadas previamente como Neisseria meningitidis, aisladas de portadores nasofaríngeos, en el período 1985-1988. A éstas se les aplicó el esquema de identificación de Knapp, a adiéndole la prueba de la producción de gamma -glutamiltransferasa, esta última y la producción de polisacárido a partir de 5 % de sacarosa permitieron realizar el diagnóstico diferencial entre N. meningitidis y Neisseria polysaccharea. Se logró identificar una cepa de N. polysaccharea, lo que constituye el primer reporte de esta especie en Cuba. The National Laboratory of Reference of Pathogenic Neisserias of Pedro Kourí Tropical Medicine Institute studied 58 strains which had been previously identified as Neisseria meningiditis and isolated from nasopharyngeal carriers from 1985-1998. They were applied the knapp detection scheme plus the glutamiltransferase production test. The latter and the polyscharide production based on 5 % sacarose allowed to make a differential diagnosis between N. meningitidis and Neisseria polyccharea. It was possible to identify a N. polysaccharia strain, a species that is reported for the first time in Cuba.
Tratamiento de la leucemia mieloide aguda del ni o en Cuba Treatment of children acute myeloid leukemia in Cuba  [cached]
Andrea Menéndez Veitía,Alejandro González Otero,Eva Svarch,Edelis Rosell Monzón
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2013,
Abstract: Introducción: la leucemia mieloide aguda representa alrededor del 20 % de las leucemias agudas de la ni ez con una respuesta al tratamiento y supervivencia menores que la leucemia linfoide aguda. Objetivo: describir los resultados obtenidos con el tratamiento de la leucemia mieloide aguda del ni o en algunos centros de Cuba en el período 2000-2008. Métodos: se trataron 46 pacientes con leucemia mieloide aguda, se excluyeron los casos con leucemia promielocítica, diagnosticados a partir del a o 2000 en las provincias occidentales, Sancti Spíritus y Villa Clara. Se aplicaron dos esquemas de tratamiento tipo BFM en dos períodos: en el primero (2000 -2003) se incluyeron 27 enfermos y en el segundo (2004-2008), 19. La diferencia fundamental entre los dos períodos consistió en la consolidación que en la segunda etapa fue de ciclos más intensos y cortos. Resultados: predominó el sexo masculino (n = 32) y la mediana de edad fue de 9 a os. La remisión inicial fue del 71 % en la primera etapa y 89 % en la segunda. La supervivencia libre de eventos (SLE) en todos los pacientes fue del 40 % a los 5 a os y la supervivencia global (SV) fue del 44 % en igual período. En la SLE en las dos etapas se encontraron diferencias significativas siendo mayor en la segunda. En los a os comprendidos entre el 2000 y el 2003 la SV a los 5 a os fue del 31 %, mientras que entre 2004 y 2008 fue del 63 %. No se empleó el trasplante de células progenitoras hematopoyéticas de forma sistemática. Conclusiones: estos resultados muestran un nivel comparable a los alcanzados a internacionalmente, lo que representa un importante logro del Sistema Nacional de Salud de Cuba. Introduction. acute myeloid leukemia represents about 20 % of all leukemias in childhood with results and survival smaller than in acute lymphoid leukemia. Objectives: to describe the results obtained with the treatment of acute myeloid leukemia in children in some Cuban centers in from 2000 to 2008. Methods: forty-six patients from Western provinces of Cuba including Sancti Spiritus and Villa Clara were treated. The majority of the patients were males. The median age was 9 years old. Two periods of treatment were applied, the first from 2000 to 2003 with 27 patients; and the second from 2004 to 2008 with 19 cases. The difference between the two periods was that in the second one the consolidation had short and intensive cycles. Results: the initial remission was 71 % in the first period and 89 % in the second. Free survival was 40 % in 5 years and the overall survival (OS) was 44 %, but in the first period the OS was 30,8 %
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