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Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension  [cached]
Makoto Aihara
Clinical Ophthalmology , 2010,
Abstract: Makoto AiharaDepartment of Ophthalmology, University of Tokyo School of Medicine, Tokyo, JapanAbstract: An elevated intraocular pressure (IOP) is one of the most important risk factors for the development of glaucoma, which causes progressive optic neuropathy. Lowering IOP is currently the only therapeutic approach to the treatment of glaucoma. Tafluprost, a novel prostaglandin analogue, was recently launched onto the market as an ocular hypotensive agent. Tafluprost is potent in its affinity for the prostanoid FP receptor and in its intraocular lowering efficacy. Moreover, it enhances the ocular hemodynamics and has neuroprotective effects. Clinical studies have demonstrated its efficacy at decreasing intraocular pressure in patients with open-angle glaucoma or ocular hypertension.Keywords: open-angle glaucoma, normal tension glaucoma, receptor affinity, intraocular pressure
Clear lens extraction and intraocular lens implantation in a case of microspherophakia with secondary angle closure glaucoma
Bhattacharjee Harsha,Bhattacharjee Kasturi,Medhi Jnanankar,DasGupta Sushobhan
Indian Journal of Ophthalmology , 2010,
Abstract: Phacoemulsification with implantation of single-piece acrylic foldable intraocular lens (IOL) in a 19-year-old boy with microspherophakia, high myopia and angle closure glaucoma is described. The associated myopia and angle closure glaucoma was severely compromising the quality of life. Post-surgical visual recovery was 20/20 with sustained normal intraocular pressure. Management of such cases at times calls for innovations in current surgical technique.
Effect of caffeine on the intraocular pressure in patients with primary open angle glaucoma
Chandra P, Gaur A, Varma S
Clinical Ophthalmology , 2011, DOI: http://dx.doi.org/10.2147/OPTH.S25291
Abstract: t of caffeine on the intraocular pressure in patients with primary open angle glaucoma Original Research (3666) Total Article Views Authors: Chandra P, Gaur A, Varma S Published Date November 2011 Volume 2011:5 Pages 1623 - 1629 DOI: http://dx.doi.org/10.2147/OPTH.S25291 Peeyush Chandra1, Ajit Gaur1, Shambhu Varma2 1Chandra Eye Research Institute, Allahabad, UP, India; 2Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD, USA Purpose: Coffee and tea are very common nonalcoholic beverages. However, their intake, particularly that of coffee, has been suggested to increase intraocular pressure (IOP) in patients with open angle glaucoma/ocular hypertension. The causative agent has been suggested to be their caffeine content. The objective of this study was to determine if this represents a direct caffeine effect. This study was therefore done using pure caffeine applied directly to the eyes. Methods: The study was conducted with five human volunteers with open angle glaucoma/ocular hypertension. IOP was measured using a Perkins applanation tonometer. Eye drops of 1% caffeine were prepared in-home. Following the initial (basal) measurement of the IOP, 50 μL of the eye drop preparation was instilled in the eye at 0-, 4-, and 6-hour intervals. IOPs were measured 30 minutes after each instillation. A second study was also undertaken following the first. In this study, the same patients instilled the eye drops three times per day for 1 week at home and then returned to the clinic on day 7. They were then again treated with caffeine eye drops as above and IOPs measured. Results: In the 1-day study, the mean basal IOP was 23.6 ± 2.80 mmHg. Thirty minutes after instillation of the drops as described, the pressures were 23.2 ± 1.93, 22.2 ± 1.99, and 22.6 ± 2.31. The basal reading was taken at 10 am and another reading was then taken at 10.30 am. Additional eye drops were instilled at 2 and 8 pm and readings taken 30 minutes after each instillation. In the 1 week study, the basal value was 22.6 ± 2.32. After instillation of the drops as above the values were 23 ± 2.16, 22.4 ± 2.27, and 23 ± 1.94. Conclusion: Administration of caffeine into the eyes of patients did not have any effect on IOP and it remained relatively unchanged. This was true in the 1-day study as well as in the 1-week study. A cumulative effect was not visible. The results therefore demonstrate that caffeine has no significant effect on IOP in patients with glaucoma. Any effects reported in coffee drinkers may therefore be related to other constituents in coffee, known to be generated pyrolytically from endogenous constituents of coffee beans by roasting at relatively high temperature, combined with the osmotic effects imposed by adequate fluid intake, known to be common in glaucoma patients.
Effect of caffeine on the intraocular pressure in patients with primary open angle glaucoma  [cached]
Chandra P,Gaur A,Varma S
Clinical Ophthalmology , 2011,
Abstract: Peeyush Chandra1, Ajit Gaur1, Shambhu Varma21Chandra Eye Research Institute, Allahabad, UP, India; 2Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD, USAPurpose: Coffee and tea are very common nonalcoholic beverages. However, their intake, particularly that of coffee, has been suggested to increase intraocular pressure (IOP) in patients with open angle glaucoma/ocular hypertension. The causative agent has been suggested to be their caffeine content. The objective of this study was to determine if this represents a direct caffeine effect. This study was therefore done using pure caffeine applied directly to the eyes.Methods: The study was conducted with five human volunteers with open angle glaucoma/ocular hypertension. IOP was measured using a Perkins applanation tonometer. Eye drops of 1% caffeine were prepared in-home. Following the initial (basal) measurement of the IOP, 50 μL of the eye drop preparation was instilled in the eye at 0-, 4-, and 6-hour intervals. IOPs were measured 30 minutes after each instillation. A second study was also undertaken following the first. In this study, the same patients instilled the eye drops three times per day for 1 week at home and then returned to the clinic on day 7. They were then again treated with caffeine eye drops as above and IOPs measured.Results: In the 1-day study, the mean basal IOP was 23.6 ± 2.80 mmHg. Thirty minutes after instillation of the drops as described, the pressures were 23.2 ± 1.93, 22.2 ± 1.99, and 22.6 ± 2.31. The basal reading was taken at 10 am and another reading was then taken at 10.30 am. Additional eye drops were instilled at 2 and 8 pm and readings taken 30 minutes after each instillation. In the 1 week study, the basal value was 22.6 ± 2.32. After instillation of the drops as above the values were 23 ± 2.16, 22.4 ± 2.27, and 23 ± 1.94.Conclusion: Administration of caffeine into the eyes of patients did not have any effect on IOP and it remained relatively unchanged. This was true in the 1-day study as well as in the 1-week study. A cumulative effect was not visible. The results therefore demonstrate that caffeine has no significant effect on IOP in patients with glaucoma. Any effects reported in coffee drinkers may therefore be related to other constituents in coffee, known to be generated pyrolytically from endogenous constituents of coffee beans by roasting at relatively high temperature, combined with the osmotic effects imposed by adequate fluid intake, known to be common in glaucoma patients.Keywords: caffeine, open an
Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension
Makoto Aihara
Clinical Ophthalmology , 2010, DOI: http://dx.doi.org/10.2147/OPTH.S6368
Abstract: ical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension Review (5410) Total Article Views Authors: Makoto Aihara Published Date March 2010 Volume 2010:4 Pages 163 - 170 DOI: http://dx.doi.org/10.2147/OPTH.S6368 Makoto Aihara Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan Abstract: An elevated intraocular pressure (IOP) is one of the most important risk factors for the development of glaucoma, which causes progressive optic neuropathy. Lowering IOP is currently the only therapeutic approach to the treatment of glaucoma. Tafluprost, a novel prostaglandin analogue, was recently launched onto the market as an ocular hypotensive agent. Tafluprost is potent in its affinity for the prostanoid FP receptor and in its intraocular lowering efficacy. Moreover, it enhances the ocular hemodynamics and has neuroprotective effects. Clinical studies have demonstrated its efficacy at decreasing intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Tafluprost once daily for treatment of elevated intraocular pressure in patients with open-angle glaucoma  [cached]
Liu Y,Mao W
Clinical Ophthalmology , 2012,
Abstract: Yang Liu, Weiming MaoDepartment of Cell Biology and Anatomy, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TXAbstract: Glaucoma is a leading cause of visual loss worldwide. Current antiglaucoma therapy focuses on lowering intraocular pressure to a safe level. In recent years, prostaglandin analogs have become the first-line agents for treating open angle glaucoma. Tafluprost, which was first reported in 2003, is a novel prostaglandin analog, and has been shown to be a potent ocular hypotensive agent in a number of preclinical and clinical studies. Also, its unique preservative-free formulation helps to decrease preservative-associated ocular disorders and improve patient compliance. In this review, studies from 2003 to 2012 focusing on the structure, metabolism, efficacy, and safety of tafluprost are summarized. These studies suggested that application of tafluprost once daily is a safe and effective treatment for patients with open angle glaucoma.Keywords: tafluprost, prostaglandin analog, glaucoma, intraocular pressure, preservative-free formulation
Anterior chamber paracentesis combined with trabeculectomy in treatment of high intraocular pressure continued state of acute angle-closure glaucoma
Xiao-Jing Zhao
Guoji Yanke Zazhi , 2013, DOI: 10.3980/j.issn.1672-5123.2013.04.28
Abstract: AIM: To investigate the effect of anterior chamber puncture combined trabeculectomy in the treatment of high intraocular pressure continued state of acute angle-closure glaucoma. METHODS: Totally 80 cases with angle-closure glaucoma from March 2011 to June 2012 in our hospital were retrospectively analyzed, and 40 cases were given trabeculectomy after anterior chamber decompression(observation group)while 40 cases were received trabeculectomy after drugs decompression(control group). The clinical efficacy was compared between the two groups. RESULTS: The postoperative vision recovery, anterior chamber angle and pupil improvement were better than the control group, and the incidence of complications were less than the control group, the difference was statistically significant(P<0.05). CONCLUSION: The efficacy of anterior chamber paracentesis combined with trabeculectomy in the treatment of high intraocular pressure continued state of acute angle-closure glaucoma is effective, and it is a simple surgery with fewer complications, which is worth to actively promote in clinic.
Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension
Dorota Pozarowska
Clinical Ophthalmology , 2010, DOI: http://dx.doi.org/10.2147/OPTH.S6369
Abstract: fety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension Review (4453) Total Article Views Authors: Dorota Pozarowska Published Date October 2010 Volume 2010:4 Pages 1229 - 1236 DOI: http://dx.doi.org/10.2147/OPTH.S6369 Dorota Pozarowska Department of Ophthalmology, Medical University, Lublin, Poland Abstract: Glaucoma is one of the most common neuropathies of the optic nerve. An elevated intraocular pressure (IOP) is a well documented risk factor for the development and progression of this disease. Until now, IOP reduction is the only well documented successful method of glaucoma treatment. Among the many hypotensive drugs, prostaglandin analogs are proved to be the most potent antiglaucoma agents, with very few systemic side effects. A new prostanoid FP receptor analog, tafluprost, has been introduced into the medical treatment of glaucoma and ocular hypertension. Many studies have shown that it is an efficient IOP-lowering drug, and that it is safe and well tolerated. A preservative-free tafluprost formulation is as potent as a preserved one, but it has fewer and milder toxic effects on the eye.
A comparison of the circadian rhythm of intraocular pressure in primary phronic angle closure glaucoma, primary open angle glaucoma and normal eyes  [cached]
Sihota Ramanjit,Saxena R,Gogoi M,Sood A
Indian Journal of Ophthalmology , 2005,
Abstract: Purpose: To evaluate the circadian rhythm of intraocular pressure (IOP) in primary chronic angle closure glaucoma (PCACG), primary open angle glaucoma (POAG), and normal eyes. Methods: Cross-sectional study of newly diagnosed patients of POAG (60 eyes), PCACG following laser iridotomy (75 eyes), and age and sex matched normal controls (75 eyes). All subjects underwent applanation tonometry at 7 a.m., 10 a.m., 1 p.m., 4 p.m., 7 p.m., and 10 p.m. by a masked observer. Circadian rhythms were classified based upon the timing and presence of peak pressure. Results: Age and gender in all three groups were comparable. Diurnal IOP fluctuations were significantly higher in PCACG (7.69 + 3.03 mmHg) and POAG (8.31 + 2.58 mmHg) groups compared to normal controls (4.83 + 2.46 mmHg). PCACG eyes and controls had similarly timed circadian rhythms, with PCACG eyes having a consistently higher IOP. At 7 and 10 a.m., IOP peaked more often in POAG eyes compared to PCACG eyes. A plateau type of circadian rhythm was most common in normal eyes. The timing of peak IOP could be significantly correlated with the type of primary glaucoma examined. Conclusion: Afternoon peaks were more common in postiridotomy PCACG eyes, similar to the rhythm in normal eyes. Morning peaks were more frequent in POAG eyes. Diurnal fluctuation > 6 mmHg, associated with an IOP of 21 mmHg or more was never seen in a normal eye.
Latanoprost ophthalmic solution in the treatment of open angle glaucoma or raised intraocular pressure: a review  [cached]
Andrea Russo,Ivano Riva,Teodoro Pizzolante,Federico Noto
Clinical Ophthalmology , 2009,
Abstract: Andrea Russo, Ivano Riva, Teodoro Pizzolante, Federico Noto, Luciano QuarantaCattedra di Malattie dell’Apparato Visivo, Università degli studi di Brescia, USVD “Centro per lo studio del Glaucoma” Spedali Civili di BresciaAbstract: Latanoprost is a prostaglandin F2-alpha isopropyl ester prodrug which is rapidly hydrolyzed by esterases in the cornea to the biologically active latanoprost acid. When latanoprost is topically administered into the eye, the cornea seems to act like as a slow-release depot to the anterior segment. One hour after administration maximum concentration is found in the iris, followed by the anterior chamber and the ciliary body. Despite extensive research, controversy remains about the real mechanism of action of this drug. Immunohistochemical data have shown that the intraocular pressure (IOP) reduction with topical prostaglandin F2-alpha is associated with a reduction of collagens within the uveoscleral outflow pathway. Evidence from several experimental and clinical studies suggests that latanoprost is a valuable addition first-line treatment alternatives for glaucoma, ocular hypertension and even angle-closure glaucoma. Strong points are its efficacy, which is demonstrated to be higher than that of brimonidine, dorzolamide and timolol with fewer systemic adverse effects; a convenient administration schedule; and the IOP-controlling pattern, which is relatively flat compared with timolol and dorzolamide, and enables better control in glaucoma progression, since large fluctuations may be associated with the risk of developing glaucoma in untreated ocular hypertensive subjects.Keywords: latanoprost, intraocular pressure, glaucoma, ocular hypertension
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