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Efeito do ultrassom associado ao gel de calêndula sobre a atividade reparadora em les es musculares experimentais = Effect of ultrasound associated with calendula gel on restorative activity in experimental muscular injuries  [cached]
Diego da Silva Ricoldy,Ana Clara de Albuquerque Botura,Juliano Yasuo Oda,Orlando Seiko Takemura
Acta Scientiarum : Health Sciences , 2010,
Abstract: Diversas técnicas têm sido propostas para o tratamento de les es musculares, sendo a do ultrassom terapêutico uma das mais utilizadas. Além dos efeitos do ultrassom, este facilitaria, ainda, a permea o de drogas pelos tecidos (fonoforese). A calêndula é um fitoterápico que apresenta atividade cicatrizante empregada popularmente no tratamento de les es. O objetivo deste estudo foi avaliar a eficácia do ultrassom, da fonoforese e a influência da aplica o tópica do gel extraído da Calendula officinalis na recupera o de les o muscular experimental em ratos. A análise histológica do músculo e a determina o da área de les o foram realizadas após o músculo tibial anterior lesionado ser tratado durante cinco dias. Os resultados indicaram que todos os grupos tratados com ultrassom e calêndulaapresentaram melhor resolu o da les o, por apresentarem maior quantidade de fibroblastos, neovasculariza o e mioblastos em rela o ao Grupo-controle. Quanto à área de les o, somente o grupo em que foi associado o ultrassom à calêndula apresentou uma área significativamente menor. Em conjunto, os dados obtidos demonstram que, no modelo experimental estudado, a fonoforese apresentou-se mais indicada para o tratamento de les es musculares. Several techniques have been proposed as treatment for muscular injuries, and therapeutic ultrasound is one of the most used. Besidesthe effects of ultrasound, it also facilitates drug flow trough the tissues (phonophoresis). Calendula is a phytotherapic which presents healing elements, popularly used on injury treatments. The objective of this study was to evaluate ultrasound effectiveness, phonophoresis, and the influence of the topic application of the gel with Calendula officinalis extract, in the recovery from experimental muscular injury in rats. After the injured front tibial muscle was treated during five days, a histological analysis of the muscle wasperformed and the injury area was determined. The results indicated that all the ultrasound/Calendula-treated groups presented better evolution in the injury, sinasce they presented more fibroblasts, neovascularization and myoblasts in relation to the control group. As to the injured area, only the group in which the ultrasound was added to Calendula presented a significantly smaller area. In all, the obtained data demonstrate that in the experimental model studied, phonophoresis was more indicated for muscle injury treatment.
Neural mobilization and static stretching in an experimental sciatica model: an experimental study Mobiliza o neural e alongamento estático em um modelo experimental de ciatalgia: estudo experimental  [cached]
Gladson R. F. Bertolini,Taciane S. Silva,Danilo L. Trindade,Adriano P. Ciena
Brazilian Journal of Physical Therapy , 2009,
Abstract: OBJECTIVE: To verify the effectiveness of neural mobilization and static stretching in reducing pain in rats submitted to experimental sciatica. METHODS: The rats (n=23) were divided into three groups: sham (SG/n=8), without intervention; stretching (STCG/n=8), treated with static stretching; and neural mobilization (NMG/n=7), treated with neural mobilization. The animals underwent an experimental model of sciatica by compression of the right ischiatic nerve with catgut suture thread. There were five consecutive sessions of treatment that began on the third day after lesion. The pain caused by the sciatica was evaluated by a functional incapacitation test that measured paw elevation time (PET), and values over 10s were indicative of pain. PET was measured at the following moments: before the lesion (M1), immediately before (M2) and after the first session (M3), immediately after the last session (M4) and 24h after the last session (M5). ANOVA was applied with repeated measures and unrepeated measures for intra- and inter-group comparison, respectively. RESULTS: In the SG, post-lesion PETs were greater than M1 (p<0.001), suggesting persistence of pain. In the STCG, post-lesion PETs were greater than M1 (p<0.001), but lower when comparing M3 vs. M4 (p<0.05) and M3 vs. M5 (p<0.01) suggesting the effectiveness of the treatment. In NMG, M2, M3 (p<0.001) and M4 (p<0.05) were greater in relation to M1, but not M5, showing that this treatment reestablished the normal PET values. CONCLUSION: Both forms of therapy were effective in reducing pain, with neural mobilization being the more effective of the two. OBJETIVO: Verificar a eficácia da mobiliza o neural e do alongamento estático na redu o da dor em ratos submetidos à ciática experimental. MéTODOS: Os ratos (n=23) foram divididos em três grupos: simulacro (GS/n=8), sem interven o; alongamento (GAL/n=8), tratados com alongamento estático; e mobiliza o neural (GMN/n=7), tratados com mobiliza o neural. Submeteram-se os animais a um modelo experimental de ciática, comprimindo o nervo isquiático direito com fio de catgut. Realizaram-se cinco sess es consecutivas de tratamento que se iniciaram no terceiro dia pós-les o. Avaliou-se a dor, provocada pela ciática, pelo teste de incapacidade funcional que mensurava o tempo de eleva o da pata (TEP) do animal, e valores maiores que 10 segundos eram indicativos de dor. O TEP foi mensurado nos momentos: antes da les o (M1), imediatamente antes (M2), após a 1a sess o (M3), imediatamente após a última sess o (M4) e 24 horas após a última sess o (M5). Aplicou-se ANOVA c
Ultra-som terapêutico contínuo térmico em modelo experimental de ciatalgia
Ciena, Adriano Polican;Oliveira, Jaques Jean Junqueira;Cunha, Núbia Broetto;Bertolini, Gladson Ricardo Flor;
Fisioterapia e Pesquisa , 2009, DOI: 10.1590/S1809-29502009000200014
Abstract: therapeutic ultrasound is a physical therapy resource for relieving sciatic pain. the aim of this study was to assess the effectiveness of continuous therapeutic ultrasound in two different power densities (0,5 w/cm2 and 1 w/cm2), on reducing pain in rats submitted to a sciatica experimental model. twenty rats were used, divided into 3 groups: g1 (n=6) submitted to sciatica and placebo treatment; g2 (n=7) submitted to sciatica and treated with 0.5 w/cm2 ultrasound; and g3 (n=7), submitted to sciatica and treated with 1 w/cm2 ultrasound. sciatica was provoked by surgical nerve compression on the right posterior limb of all animals. treatment on the surgical procedure region consisted in ten daily 5-minute sessions, starting on the 3rd postoperative day. pain was inferred by the time of paw elevation (tpe) during gait, measured before the surgery and on five further moments. results showed tpe increase in all groups after surgery; but in both groups actually treated with ultrasound a significant tep decrease was noticed, practically reaching initial values, the decrease being more precocious and intense in g2. continuous ultrasound such as was delivered was hence effective in reducing sciatic pain.
Uso do laser, 670 nm, no quadro álgico de ratos submetidos à modelo experimental de ciatalgia
Cunha, Núbia Broetto;Moesch, Juliana;Mallmann, Juliana Schmatz;Ciena, Adriano Policam;Bertolini, Gladson Ricardo Flor;
Revista Brasileira de Medicina do Esporte , 2008, DOI: 10.1590/S1517-86922008000200006
Abstract: sciatica is caused by the sciatic nerve compression in some point of its course, and its treatment consists of solving the nervous compression cause, either by surgical or conservative treatment. some physiotherapeutic resources act basically in the reduction of the symptoms caused by this disturbance. the aim of this study was to verify the effectiveness of the laser 670 nm, in two different energy densities, in the pain reduction, in rats submitted to a sciatica experimental model. eighteen rats, divided in 3 groups were used: g1 (n=6) submitted to sciatica and simulated treatment (placebo group), g2 (n=6) submitted to sciatica and treated with laser 2 j/cm2, g3 (n=6) submitted to sciatica and irradiated with laser 4 j/cm2. the hamstring nerve of the animals' right hind limb was exposed and compression with catgut thread in 4 points of the nerve was performed. on the 3rd post-operation day, the treatment was begun with laser in the surgical procedure area of the right hind limb for 10 days. the time during which the limb remained on the air was verified through gait in the following periods: previous to the sciatica, before and after treatment. the results have demonstrated that the laser was not effective in the pain reduction; however, with 4 j/cm2 there was positive effect, without complete functionality reestablishment.
Avalia??o do exercício físico como fator de analgesia em um modelo experimental de ciatalgia
Gaffuri, Juliana;Meireles, Anamaria;Rocha, Bruno Pogorzelski;Rosa, Camila Thieime;Artifon, Elisangela Lourdes;Silva, Lígia Inez;Moreira, Natalia Boneti;Bertolini, Gladson Ricardo Flor;
Revista Brasileira de Medicina do Esporte , 2011, DOI: 10.1590/S1517-86922011000200009
Abstract: objective: to evaluate the efficacy of physical exercise (swimming and jumping), with and without overload, working in reducing the pain of rats undergone to an experimental model of sciatica. methods: 24 rats were divided into four groups: placebo (gp), swimming group (ng) swimming 10% group (gn10) and leap group (gs). all groups were submitted to the experimental sciatica model and assessed for pain post-exercise for the functional disability test and the von frey filament. results: in comparison within groups there were significant differences in the moments after injury with the pre-injury, for both assessment instruments. with von frey filament was observed a significant difference in group gn10 and gs in the final moments of evaluation. in comparisons between groups were not statistically significant differences obtained with any assessment instrument. conclusion: treatment with physical exercise was not effective in reducing pain in rats subjected to experimental sciatica model.
Efeitos a curto prazo de "stents" n o recobertos e recobertos com politetrafluoroetileno em aorta de suínos: um modelo experimental  [cached]
Grüdtner Marco Aurélio,Pereira Adamastor Humberto,Costa Luiz Francisco Machado da,Souza Gilberto Gon?alves de
Acta Cirurgica Brasileira , 2004,
Abstract: OBJETIVO: Descrever um estudo experimental avaliando através da morfometria digital o espessamento intimal na parede arterial após o implante de "stents" metálicos auto-expansíveis recobertos ou n o com politetrafluoroetileno (PTFE) na aorta de suínos. MéTODOS: Em três grupos de suínos jovens uma bainha introdutora de 12 F foi inserida na aorta abdominal distal. Os animais do grupo I (n=5) foram considerados controle. Os animais do grupo II (n=10) receberam o implante de um stent metálico auto-expansível n o recoberto. No grupo III (n=10) um stent auto-expansível recoberto com PTFE foi inserido. Após quatro semanas os animais foram sacrificados e os espécimes arteriais foram retirados, sendo o espessamento intimal quantificado pela análise morfométrica. RESULTADOS: Na compara o entre os grupos I, II e III quanto às áreas da íntima, média e índice intimal, n o foi observada varia o estatisticamente significativa. Diferen as foram observadas entre os grupos em rela o às áreas luminais proximais (p=0,0036) e distais (p=0,044). Através dos testes de compara o múltipla para Kruskal-Wallis foi identificada uma diferen a entre os grupos I e II. Entretanto, quando essas variáveis foram controladas pelo fator peso (rela o área luminal/peso), a diferen a n o foi mais observada. CONCLUS ES: Nesse estudo a curto prazo, o revestimento de PTFE n o esteve associado a adicional espessamento intimal além daquele promovido pelo dispositivo metálico em artérias de grande calibre e condi es de alto fluxo.
APPLICATION OF ULTRASOUND TO CONTROL OF ASPERGILLUS FLAVUS IN COSMETICS = APLICA O DE ULTRASSOM NO CONTROLE DE ASPERGILLUS FLAVUS EM COSMéTICOS  [cached]
Kassima Timoni Góes-Campanha,Dejanira de Franceschi de Angelis,Gerson Antonio Santarine,Carlos Renato Corso
Holos Environment , 2011,
Abstract: The effect of ultrasound on organic compounds in living tissue and are often related to the cavitation’ phenomenon, a term used to describe the formation of cavities or bubbles in a liquid medium containing varying amounts of gas or vapor that are dissolved in the middle. In medicine it is suggested that ultrasound of high intensity is able to cause some reduction in certain infectious agents and microbiology, mechanisms of inactivation of cells appear to be associated with cavitation. Due to the high power of fungal contamination of cosmetics, it is important to develop new techniques to preserve it to rapid fungi deterioration and subsequent consumer health hazard. On the present work it was probed the efficiency of ultrasound in decreasing the growth of Aspergillus flavus in cosmetic.Thus contaminated samples with the above mentioned fungus, were irradiated at constant temperature (25 oC) and power (600W/cm2), for a variety of time exposure: 0 (control), 12, 16, and 20 minutes. The ultrasound generator model VCX- 600 was utilized.It was possible to show that the use of ultrasound is efficient in decreasing the growth of microrganisms and thus preserve cosmetic which went from 35,000 CFU/mL to 50 CFU/mL. Ultrasound is a excellent biocide agent in preparation and preservation of emulsion-type cosmetics. Twenty minutes of continuous irradiation yelded an almost complete depletion of microrganisms. = Devido ao alto poder de contamina o dos cosméticos por fungos, é de grande importancia o desenvolvimento de novas técnicas para preserva o desses, uma vez que a contamina o microbiológica pode, além de causar a deteriora o do produto, apresentar danos à saúde do consumidor. Procurou-se, ent o, nesse trabalho, determinar a eficácia do ultrassom na diminui o do crescimento do fungo Aspergillus flavus em cosméticos. Para isso, amostras de cosméticos contaminados com o fungo foram irradiadas em equipamento gerador de ultrassom modelo VCX-600, nos tempos 0 (controle), 12 minutos, 16 minutos e 20 minutos, com a mesma intensidade (600 Watts/cm2) e temperatura constante (25 oC). Mostrou-se que o uso do ultrassom é eficiente na inibi o do crescimento do microrganismo e, consequentemente, na preserva o dos cosméticos, comprovando ser o ultrassom um excelente agente biocida na prepara o e preserva o de produtos cosméticos emulsionáveis. Uma diminui o significativa foi constatada após 20 minutos de irradia o, com o aparelho operando de modo contínuo.
Fridel-Crafts alkylation of iodine catalyed by ultrasound assisted Alquila o de Fridel-Crafts catalisada por iodo assistida por ultrassom
Manoel G. de Oliveira,Deluana M. Neto,Tairine Pimentel,Brenda G. Sturnich
Orbital : the Electronic Journal of Chemistry , 2012,
Abstract: Triarymethanes (TRAMs) are used as antitubercular agents, antitumor or antiviral.1 Was weighed 2 mmol of (1a), 1 mmol of (2a), 10 mol% of I2 in 5 mL of CH2Cl2, the reaction was brought to ultrasound bath (SONIC MODEL LS-4, 7D) of 44 kH and 150 W (Scheme 1).The product was purified on silica gel-60, eluting mixture 8:2 of (Hexano:Ethyl acetate). Under these conditions 65% of the product (3a) was obtained. The compound was characterized by third m.p. 161oC (161-162oC).1 The Fridel-Crafts alkylation catalyzed by I2 bath ultrasound occurs at short reaction time requiring less energy expenditure compared to the method of agitation. It is intended to increase the study of various aromatic compounds (1), different aldehydes (2) and vary the use of solvents. Trimetilalcanos (TRAMs) s o empregados como agentes antitubercular, antitumoral ou antiviral. Pesou-se 2 mmol de 1a, 1 mmol de 2a, 10 mol% de I2 em 5 mL de CH2Cl2, a rea o foi levada ao banho de ultrassom (SONIC-MODELO LS-4,7D) de 44 kH e 150 W, (Esquema 1). A purifica o do produto foi em sílica gel-60, em mistura de eluente 8:2 (Hexano:Acetato de etila). Nessas condi es 65% do produto (3a) foi obtido. O compostos 3a foi caracterizado pelo p.f. 161°C (161-162°C)1. A alquila o de Fridel–Crafts catalisada por I2 em banho de ultrassom ocorre em menor tempo de rea o demandando menor gasto de energia se comparada ao método de agita o. Pretende-se ampliar o estudo envolvendo diferentes compostos aromáticos (1), diferentes aldeídos (2) bem como variar o uso de solventes.
A??o anti-inflamatória da fra??o lipídica do Ovis aries associado ao ultrassom terapêutico em modelo experimental de tendinite em ratos (Rattus norvegicus)
Martins, Marcelino;Maia Filho, Antonio L. M.;Costa, Charllyton L. S.;Coelho, Nayana P. M. F.;Costa, Maricilia S.;Carvalho, Regiane A.;
Brazilian Journal of Physical Therapy , 2011, DOI: 10.1590/S1413-35552011000400007
Abstract: background: studies have demonstrated the beneficial effects of topical application of fatty acids as healing agents. the lipid fraction of ovis aries have an anti-inflammatory action that accelerates the healing process. ultrasound increases blood flow and the extensibility of collagen structures and tendons. objectives: to assess the anti-inflammatory action of the ovis aries lipid fraction associated to pulsed therapeutic ultrasound and friction in an induced tendinitis model. methods: fifty wistar rats were divided into four groups: control that consisted of ovis aries gel for topical use; pulsed ultrasound plus oil free sterile lotion; pulsed ultrasound plus ovis aries gel; and oil free sterile lotion for topical use alone. to induce tendinitis a 10μl intratendinous injection of collagenase was injected into the right achilles tendon of rats. treatment consisted of daily applications of ultrasound using the following parameters: 10% pulsed mode, 10% pulsed frequency of 1 mhz and intensity of 0.5 w/cm2 for seven or fourteen days. results: after 7 days of treatment, only the ovis aries plus ultrasound group showed statistically significant difference when compared to the control group.the variation in the number of inflammatory cells on animals treated for fourteen days for the control, ultrasound plus oil free, ultrasound plus ovis aries, ovis aries plus massage and massage plus oil free groups were statistically significant different, p<0.01. it was observed in animals treated for seven days that the ultrasound plus ovis aries group was statistically significant better than the control group, p<0.05. conclusion: it can be concluded that treatment using ultrasound plus ovis aries is more effective than other treatments as it produces significantly better reduction on the number of inflammatory cells at 7 and 14 days.
Modelo experimental de tumor de Walker  [cached]
Moraes Sandra Pedroso de,Cunha Aguinelo,Reis Neto José Alfredo dos,Barbosa Humberto
Acta Cirurgica Brasileira , 2000,
Abstract: Com o objetivo de padronizar normas técnicas para obten o de modelo animal com tumor de Walker 256 e de estabelecer o número de células tumorais necessárias para que esse tumor tenha grande porcentagem de pega e longevidade, possibilitando o desenvolvimento de pesquisas em várias áreas da saúde, foi realizado trabalho em duas etapas. Na primeira foram utilizados 120 ratos para treinamento e defini o da técnica. Na segunda etapa foram utilizados 84 ratos, sendo estes separados em 7 grupos (G) de 12 animais cada. O tumor, na forma ascítica, foi inoculado no tecido celular subcutaneo do dorso dos ratos com os seguintes números de células: GI, 1 x 10(7); GII, 5 x 10(6); GIII, 2,5 x 10(6); GIV, 1 x 10(6); GV, 5 x 10(5); GVI, 3 x 10(5) e GVII, 2 x 10(5). Foram avaliadas a porcentagem de pega e a longevidade nos grupos. Os animais dos GI, GII, GIII e GIV obtiveram 100% de desenvolvimento tumoral, porém baixa longevidade. Os dos GV e GVI obtiveram desenvolvimento tumoral em frequência maior que 90% e longevidade satisfatória. Os do GVII n o apresentaram desenvolvimento tumoral. Concluiu-se que todos os procedimentos devem ser exaustivamente treinados e que o número de células tumorais viáveis para inocula o, em tecido celular subcutaneo de ratos, deve estar na faixa entre 5 x 10(5) e 3 x 10(5).
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