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Padroniza??o dos extratos de Cissus sicyoides L. (Insulina vegetal) e identifica??o de carotenos
Silva, Geraldo Alves da;Almeida-Muradian, Ligia Bicudo de;Akisue, Gokithi;Ferro, Vicente de Oliveira;
Revista Brasileira de Farmacognosia , 1996, DOI: 10.1590/S0102-695X1996000100008
Abstract: cissus sicyoides l. has commonly been known in folk medicine as vegetable insulin and used by its hypoglicemic properties. extracts of the plant have been examined and carotenes were identified in the acetonic fraction. analysis of the fluid extract of the plant has also been effected and the chromatopraphic profile established.
Estudo fitoquímico e avalia??o do potencial antidiabético do Cissus sicyoides L. (Vitaceae)
Beltrame, Flávio Luís;Sartoretto, Juliano Luis;Bazotte, Roberto Barbosa;Cuman, Roberto Nakamura;Cortez, Diógenes Aparício Garcia;Fernandes, Luiz Claudio;Tchaikovski, Osvaldo;
Química Nova , 2001, DOI: 10.1590/S0100-40422001000600014
Abstract: the effect of hydroalcoholic extracts (he) obtained from leaves of cissus sicyoides (cs) on glucose tolerance (gt) was investigated in rats treated with dexametasone (dex). our results showed that he intensified the decreased gt promoted by (dex). additionally, the flavonoids kaempferol 3-o-rhamnoside and quercetin 3-o-rhamnoside, obtained from aerial parts of cs, were used to study the incorporation of glucose to glycogen in soleo muscle. the results showed that both flavonoids did not show effect on glycogen synthesis. thus, our data, in contrast to popular believe, did not reveal antidiabetic activity to sc.
Estudo fitoquímico e avalia o do potencial antidiabético do Cissus sicyoides L. (Vitaceae)  [cached]
Beltrame Flávio Luís,Sartoretto Juliano Luis,Bazotte Roberto Barbosa,Cuman Roberto Nakamura
Química Nova , 2001,
Abstract: The effect of hydroalcoholic extracts (HE) obtained from leaves of Cissus sicyoides (CS) on glucose tolerance (GT) was investigated in rats treated with dexametasone (DEX). Our results showed that HE intensified the decreased GT promoted by (DEX). Additionally, the flavonoids kaempferol 3-O-rhamnoside and quercetin 3-O-rhamnoside, obtained from aerial parts of CS, were used to study the incorporation of glucose to glycogen in soleo muscle. The results showed that both flavonoids did not show effect on glycogen synthesis. Thus, our data, in contrast to popular believe, did not reveal antidiabetic activity to SC.
Estudo toxicológico pré-clínico agudo com o extrato hidroalcoólico das folhas de Cissus sicyoides L. (Vitaceae)
Vasconcelos, Tereza Helena Cavalcanti de;Modesto-Filho, Jo?o;Diniz, Margareth de Fátima Formiga Melo;Santos, Hosana Bandeira;Aguiar, Fernanda Burle de;Moreira, Patrícia Vasconcelos Leit?o;
Revista Brasileira de Farmacognosia , 2007, DOI: 10.1590/S0102-695X2007000400018
Abstract: the aim of the study was to carry through pre-clinical toxicological assay to analyze the toxicity of the plant. in the inquiry of the ld50 groups of male swiss rats (n = 10) were given orally 5.0 g/kg, and 2.0 g/kg intraperitoneally, of the water fraction of the leaves (wfl) of cissus sicyoides l. blood was removed through brachial plexus after seven days, for laboratory analysis of hematological and biochemical parameters. in the anatomopathological study, the animals had been examined macro and microscopically, with dissection of lung, heart, liver and kidneys. for analysis of the data techniques of descriptive and inferencial statistics had been used. in the evaluation of the hematological and biochemical parameters of the swiss rats, alterations in aspartate aminotransferase (ast), alanine aminotransferase (alt) and alkaline phosphatase (fal) had been detected, characterizing the demonstrated hepatic alterations in the histopathological study. in the histological evaluation of the rats's liver, submitted to the poisoning, reactionary hepatitis with chronic linfocity portite was proven and to lobular multifocal, hiperplasia kupferiana, focal collapses of the reticular tram, absence of fibrosis, absences of cellular atipias and reactionary subcapsulite. the acute pre-clinical toxicological study demonstrated hepatic alterations in rats.
Cytotoxic, antitumor and leukocyte migration activities of resveratrol and sitosterol present in the hidroalcoholic extract of Cissus sicyoides L., Vitaceae, leaves  [cached]
Flávia R. S. Lucena,Edvaldo R. Almeida,Jaciana S. Aguiar,Teresinha G. Silva
Revista Brasileira de Farmacognosia , 2010,
Abstract: Cissus sicyoides L. pertains to the Vitaceae family. It is popularly known as "insulina, cipo-pucá, bejuco caro, puci, anil trepador". A vasoconstrictor effect and an antibacterial activity have also been allocated to it. In Brazil, C. sicyoides was evaluated for its anticonvulsant and anti-diabetc properties. Phytochemistry studies identified and isolated sitosterol and resveratrol compounds from its aerial parts which are pointed out as having antitumor activities. The goal of this study was to investigate the cytotoxic and antitumor activities of Cissus sicyoides hydroalcoholic extract as well as its ability to repair leukocytes cells to injured tissue. Cissus sicyoides did not demonstrate cytotoxic activity but showed an inhibition of tumor growth in face of the tumors tested. The extract had a strong chemotactic effect on the twenty four hours period after treatment. The hidroalchoolic extract of Cissus sicyoides presented antitumor activity which was prompted by T lymphocytes recruitment to the local lesion and suggests a new pathway to antitumor activity by activation of lymphoid lineage. Cissus sicyoides pertence à família das Vitaceae. é conhecido popularmente como "insulina, cipó-puca, bejuco caro, puci, anil trepador". Esta planta apresenta efeito vasoconstritor eatividade antibacteriana. No Brasil, C. sicyoides foi avaliado pelas suas propriedades anticonvulsivante e anti-diabética. Estudos fitoquímicos identificaram e isolaram a partir de suas partes aéreas o sitoesterol e o resveratrol compostos que s o apontados por apresentar atividade antitumoral. O objetivo deste estudo foi investigar as atividades citotóxica e antitumoral do extrato hidroalcoólico Cissus sicyoides bem como a sua capacidade de recrutar leucócitos para os tecidos lesados. Cissus sicyoides n o demonstrou atividade citotóxica, mas apresentou uma inibi o do crescimento tumoral frente aos tumores testados. O extrato teve um forte efeito quimiotático 24 h após o tratamento. O extrato hidroalcoólico de Cissus sicyoides apresentou atividade antitumoral, relacionada ao recrutamento de linfócitos T para o local da les o sugerindo que esta atividade esteve relacionada à ativa o da linhagem linfóide.
Evaluation of the Antidiabetic and Antibacterial Activity of Cissus sicyoides
Beltrame, Flavio Luis;Pessini, Greisiele Lorena;Doro, Dani Luce;Dias Filho, Benedito Prado;Bazotte, Roberto Barbosa;Cortez, Diógenes Aparício Garcia;
Brazilian Archives of Biology and Technology , 2002, DOI: 10.1590/S1516-89132002000100004
Abstract: in this work we investigated the antidiabetic and antibacterial effect of cissus sicyoides (cs) from brazil. diabetic rats that received water (a group) or extracts from the aerial parts of the plant (cs group) during four weeks were employed. after this period, serum levels of glucose, cholesterol and triglycerides were measured. glycemia was not affected by treatment with cs. however, there was an increased cholesterol and triglyceride level in cs group. in addition, bioassay-guided fractionation of methanolic extract from aerial parts of cs was performed for isolation of antibacterial compounds.b-sitosterol and sitosterol-b-d-glucopyranoside isolated showed antibacterial activity against bacillus subtilis with minimal inhibitory concentrations (mics) of 50 mg/ml and 100 mg/ml, respectively. in spite of popular belief, cs did not show antidiabetic activity. however, two compounds isolated from aerial parts of the plant (b-sitosterol and sitosterol-b-d-glucopyranoside) showed antibacterial activity.
Evaluation of the Antidiabetic and Antibacterial Activity of Cissus sicyoides  [cached]
Beltrame Flavio Luis,Pessini Greisiele Lorena,Doro Dani Luce,Dias Filho Benedito Prado
Brazilian Archives of Biology and Technology , 2002,
Abstract: In this work we investigated the antidiabetic and antibacterial effect of Cissus sicyoides (CS) from Brazil. Diabetic rats that received water (A group) or extracts from the aerial parts of the plant (Cs group) during four weeks were employed. After this period, serum levels of glucose, cholesterol and triglycerides were measured. Glycemia was not affected by treatment with CS. However, there was an increased cholesterol and triglyceride level in Cs group. In addition, bioassay-guided fractionation of methanolic extract from aerial parts of CS was performed for isolation of antibacterial compounds.beta-Sitosterol and sitosterol-beta-D-glucopyranoside isolated showed antibacterial activity against Bacillus subtilis with minimal inhibitory concentrations (MICs) of 50 mug/ml and 100 mug/ml, respectively. In spite of popular belief, CS did not show antidiabetic activity. However, two compounds isolated from aerial parts of the plant (beta-sitosterol and sitosterol-beta-D-glucopyranoside) showed antibacterial activity.
Cytotoxic, antitumor and leukocyte migration activities of resveratrol and sitosterol present in the hidroalcoholic extract of Cissus sicyoides L., Vitaceae, leaves
Lucena, Flávia R. S.;Almeida, Edvaldo R.;Aguiar, Jaciana S.;Silva, Teresinha G.;Souza, Valdênia M. O.;Nascimento, Silene C.;
Revista Brasileira de Farmacognosia , 2010, DOI: 10.1590/S0102-695X2010005000002
Abstract: cissus sicyoides l. pertains to the vitaceae family. it is popularly known as "insulina, cipo-pucá, bejuco caro, puci, anil trepador". a vasoconstrictor effect and an antibacterial activity have also been allocated to it. in brazil, c. sicyoides was evaluated for its anticonvulsant and anti-diabetc properties. phytochemistry studies identified and isolated sitosterol and resveratrol compounds from its aerial parts which are pointed out as having antitumor activities. the goal of this study was to investigate the cytotoxic and antitumor activities of cissus sicyoides hydroalcoholic extract as well as its ability to repair leukocytes cells to injured tissue. cissus sicyoides did not demonstrate cytotoxic activity but showed an inhibition of tumor growth in face of the tumors tested. the extract had a strong chemotactic effect on the twenty four hours period after treatment. the hidroalchoolic extract of cissus sicyoides presented antitumor activity which was prompted by t lymphocytes recruitment to the local lesion and suggests a new pathway to antitumor activity by activation of lymphoid lineage.
Hypoglycemic and anti-lipemic effects of the aqueous extract from Cissus sicyoides  [cached]
Viana Glauce SB,Medeiros Ana Carolina C,Lacerda Ana Michelle R,Leal L Kalyne AM
BMC Pharmacology , 2004, DOI: 10.1186/1471-2210-4-9
Abstract: Background Cissus sicyoides (Vitaceae) is a medicinal plant popularly known in Brazil as "cipó-pucá, anil-trepador, cortina, and insulina". The plant is used in several diseases, including rheumatism, epilepsy, stroke and also in the treatment of diabetes. In the present work, we studied the hypoglycemic and anti-lipemic effects of the aqueous extract prepared from fresh leaves of the plant (AECS), in the model of alloxan-induced diabetes in rats. In addition, hepatic enzyme levels were also determined. Results Results showed that the daily treatment of diabetic rats with AECS for 7 days (100 and 200 mg/kg, p.o.) significantly decreased blood glucose levels in 25 and 22% respectively, as compared to the same groups before AECS treatment. No significant changes were seen in control diabetic rats before (48 h after alloxan administration) and after distilled water treatment. While no changes were seen in total cholesterol levels, a significant decrease was observed in plasma triglyceride levels, in the alloxan-induced diabetic rats after AECS treatment with both doses, as compared to the same groups before treatment. Significant decreases in blood glucose (25%) and triglyceride levels (48%) were also observed in the alloxan-induced diabetic rats after 4 days treatment with AECS (200 mg/kg, p.o.). Aspartate (AST) and alanine (ALT) aminotransferases levels, in diabetic controls and AECS-treated rats, were in the range of reference values presented by normal rats. Conclusions The results justify the popular use of C. sicyoides, pointing out to the potential benefit of the plant aqueous extract (AECS) in alternative medicine, in the treatment of type 2 diabetes mellitus.
ESTUDO DA PREPARA O DOS EXTRATOS DE PRóPOLIS E SUAS APLICA ES  [cached]
PARK Yong Kun,IKEGAKI Masaharu,ABREU José A. da Silva,ALCICI Nívia M. Freire
Ciência e Tecnologia de Alimentos , 1998,
Abstract: A obten o dos extratos etanólicos de própolis foi feita utilizando água e diferentes concentra es de etanol como solventes. Esses extratos foram analisados quanto ao seu espectro de absor o por espectrofotometria na regi o ultravioleta ("U.V. scanning"), por cromatografia em camada delgada de alta performance e por cromatografia liquida de alta eficiência (CLAE). O pico de absor o máxima de todos os extratos foi a 290 nm sendo o extrato etanólico a 80% o que apresentou maior absor o. A maioria dos flavonóides foram extraídos nas concentra es alcóolica entre 60 a 80%. Foram testados ainda o efeito anrirnicrobiano, antioxidante e anflinflamatório desses extratos. Verificou-se que os extratos etanólicos de própolis entre 60 a 80% inibiu satisfatoriamente o crescimento microbiano e os extratos etanólicos a 70 e 80% apresentaram grande atividade antioxidante, e ainda, o extrato etanólico a 80% foi a que melhor resultado apresentou sobre a inibi o da atividade da enzima hialuronidase.
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