Article citations

    Kleinman, C.L.; Majewski, J. Comment on “Widespread RNA and DNA sequence differences in the human transcriptome”. Science 2012, 335, 1302, doi:10.1126/science.1209658.

has been cited by the following article:

  • TITLE: The Human Transcriptome: An Unfinished Story
  • AUTHORS: Mihaela Pertea
  • KEYWORDS: transcriptome, pervasive transcription, RNA-seq, mRNA, ncRNA
  • JOURNAL NAME: Genes DOI: 10.3390/genes3030344 Sep 07, 2014
  • ABSTRACT: Despite recent technological advances, the study of the human transcriptome is still in its early stages. Here we provide an overview of the complex human transcriptomic landscape, present the bioinformatics challenges posed by the vast quantities of transcriptomic data, and discuss some of the studies that have tried to determine how much of the human genome is transcribed. Recent evidence has suggested that more than 90% of the human genome is transcribed into RNA. However, this view has been strongly contested by groups of scientists who argued that many of the observed transcripts are simply the result of transcriptional noise. In this review, we conclude that the full extent of transcription remains an open question that will not be fully addressed until we decipher the complete range and biological diversity of the transcribed genomic sequences.