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has been cited by the following article:
- TITLE: DP-b99 Modulates Matrix Metalloproteinase Activity and Neuronal Plasticity
- AUTHORS: Marine Yeghiazaryan, Izabela Rutkowska-Wlodarczyk, Anna Konopka, Grzegorz M. Wilczyński, Armenuhi Melikyan, Eduard Korkotian, Leszek Kaczmarek, Izabela Figiel
JOURNAL NAME: PLOS ONE
Sep 06, 2014
- ABSTRACT: DP-b99 is a membrane-activated chelator of zinc and calcium ions, recently proposed as a therapeutic agent. Matrix metalloproteinases (MMPs) are zinc-dependent extracellularly operating proteases that might contribute to synaptic plasticity, learning and memory under physiological conditions. In excessive amounts these enzymes contribute to a number of neuronal pathologies ranging from the stroke to neurodegeneration and epileptogenesis. In the present study, we report that DP-b99 delays onset and severity of PTZ-induced seizures in mice, as well as displays neuroprotective effect on kainate excitotoxicity in hippocampal organotypic slices and furthermore blocks morphological reorganization of the dendritic spines evoked by a major neuronal MMP, MMP-9. Taken together, our findings suggest that DP-b99 may inhibit neuronal plasticity driven by MMPs, in particular MMP-9, and thus may be considered as a therapeutic agent under conditions of aberrant plasticity, such as those subserving epileptogenesis.