Article citations

    Mahon P. C, Hirota K, Semenza G. L (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15: 2675–2686.

has been cited by the following article:

  • TITLE: Nothing Iffy about HIF in the Hypothalamus
  • AUTHORS: Sam Virtue ,Antonio Vidal-Puig
  • JOURNAL NAME: PLOS Biology DOI: 10.1371/journal.pbio.1001116 Aug 25, 2014
  • ABSTRACT: Two crucial biological processes are (1) the sensing and coordination of responses to low oxygen levels and (2) the control of food intake and energy expenditure. The hypoxia-inducible factor (HIF) family of proteins is known to regulate responses to low oxygen, whereas neuropeptides derived from proopiomelanocortin (POMC) are implicated in the control of food intake and energy expenditure. It is now becoming apparent that these two apparently disparate processes may be linked, with the exciting discovery that HIF proteins can act in the brain to regulate food intake and energy expenditure as reported in the current issue of PLoS Biology. This primer discusses the traditional role of HIF proteins in terms of responding to oxygen levels in the periphery and also their new role in coordinating responses to nutrients in the brain through regulation of POMC.