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- TITLE: Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis
- AUTHORS: Gao-De Li
- KEYWORDS: Chromatin Configuration, Oncogenesis, 3D Genome, Cancer, Cell Differentiation, Cell Cycle, Gene Regulation, Gene Activity
JOURNAL NAME: Open Access Library Journal
Feb 01, 2019
More than 30 years ago, we published a paper entitled as “Abnormal Chromatin Configuration and Oncogenesis”, which proposed the first hy-pothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis are presented.