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has been cited by the following article:
- TITLE: Similar Pathogen Targets in Arabidopsis thaliana and Homo sapiens Protein Networks
- AUTHORS: Paulo Shakarian, J. Kenneth Wickiser
JOURNAL NAME: PLOS ONE
Sep 11, 2014
- ABSTRACT: We study the behavior of pathogens on host protein networks for humans and Arabidopsis - noting striking similarities. Specifically, we preform -shell decomposition analysis on these networks - which groups the proteins into various “shells” based on network structure. We observe that shells with a higher average degree are more highly targeted (with a power-law relationship) and that highly targeted nodes lie in shells closer to the inner-core of the network. Additionally, we also note that the inner core of the network is significantly under-targeted. We show that these core proteins may have a role in intra-cellular communication and hypothesize that they are less attacked to ensure survival of the host. This may explain why certain high-degree proteins are not significantly attacked.