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Antibacterial activity of orsellinates

DOI: 10.1590/S1517-83822003000300002

Keywords: orsellinates, lecanoric acid, orsellinic acid, antibacterial activity.

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in order to obtain new compounds with antibacterial activity, the derivatives 2,4-dihydroxy-6-methylbenzoic acid (orsellinic acid) and 2,4-dihydroxy-6-methylbenzoates (orsellinates) were obtained through alcoholyses of lecanoric acid. all these substances were tested against gram-positive and gram-negative bacteria by a microdilution method. staphylococcus aureus, xanthomonas campestris var. vesicatoria and ralstonia solanacearum were most sensitive to n-propyl 2,4-dihydroxy-6-methylbenzoate, n-pentyl 2,4-dihydroxy-6-methylbenzoate and n-hexyl 2,4-dihydroxy-6-methylbenzoate with mic (minimal inhibitory concentration) values ranging from 62.5 to 7.8 μg×ml1. these results showed that homologation in carbon chain may lead to compounds with more pronunced activities.


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