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Expression of p53, Ki-67 and c-erb B2 in growth hormone-and/or prolactin-secreting pituitary adenomas

DOI: 10.1590/S0004-282X2006000100013

Keywords: pituitary adenomas, growth hormone, prolactin, p53, ki-67, c-erb b2, immunohistochemistry.

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Abstract:

the subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. in this study we investigated the presence of p53, ki-67 and c-erb b2 in 38 pituitary adenomas with immunohistochemical positivity for gh and prolactin (n=26; 68.4%), for prolactin (n=9; 23.7%) and for gh (n=3. 7.8%). the analyses revealed the following results: 24 (63.2%) tumors expressed variable positivity for c-erb b2, 11 (28.9%) expressed p53 positivity and 11 (28.9%) tumors were variably positive for ki-67. our results demonstrated a high percentage of gh/prolactin-, prolactin- and gh-secreting tumors with immunohistochemical positivity for c-erb b2. once this membrane receptor is related to growth factors egf and tgfa and both have a definite effect on tumor growth, our data suggest a possible role for c-erb b2 on the evolution of these tumors.

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