the purpose of the present article is to present and discuss two cases of globe su-blu-xation in the active phase of myogenic graves' orbitopathy and to evaluate the prevalence of this phenomenon. two patients with the myogenic variant of graves' orbitopathy that had being treated with oral and intravenous steroid pulses developed globe subluxation. both had to have urgent eyelid and orbital decompression. after these observations, we reviewed the medical records of a sample of 284 patients (482 orbits) who had had orbital decompression at our institution from 1992 to 2010, with a search for cases presenting severe proptosis or globe subluxation in the active phase of myogenic graves' orbitopathy. no patient had to have decompression for globe subluxation in the active phase of graves' orbitopathy. the prevalence of this event as an indication for surgery in the myogenic variant of graves' orbitopathy was therefore 0.7% (2/284) or even less. the combination of lowering the upper eyelid and orbital decompression had a dramatic therapeutic effect on these patients des-pite the presence of intense inflammatory signs in the orbits. in conclusion, patients affected with the myogenic variant of graves' orbitopathy may develop globe subluxation. urgent surgical treatments should not be postponed despite the presence of active inflammation.