purpose: to verify if patients with primary open-angle glaucoma with hla class i haplotypes (a9-b12, a2-b40, a1-b8) associated with this disease may have a greater rate of progression than patients who do not present these haplotypes. methods: anatomical and functional glaucoma evaluation (cup-to-disc ratio and visual field) of 25 patients (six of them with one of the haplotypes associated with glaucoma) followed at the glaucoma outpatient clinic of the university hospital, ribeir？o preto school of medicine, s？o paulo university (hcfmrp-usp) for ten years after typing of their hla antigens in order to compare with their previous condition. results: a greater increase of the cup-to-disc ratio was observed in patients with hla haplotypes associated with primary open-angle glaucoma predisposition. however, no significant differences in functional damage progression or in retinal nerve fibers loss were detected between them and other patients with glaucoma. conclusion: the present results indicate an association of class i hla haplotypes with progression of anatomic alterations of the optic nerve head in glaucomatous patients.