the high concentration of poultry litter in some regions has caused environmental pollution because of excess of nutrients, pathogenic microorganisms and chemical residues. in order to minimize these impacts, the producers have been stimulated to composting the poultry litter before its application as a fertilizer, however there are many doubts concerning the efficiency of this treatment. the goal of this research was analyse the persistence of pathogens and the salinomycin antibiotic in unturned static composting piles of poultry litter. the three used composting treatments were: csc treatment (poultry litter with soil layers and covered with grass), cp (poultry litter covered with polyethylene) and ccc (poultry litter with grass layers and covered with grass). it was attended the evolution of the temperature of the layers, humidity, escherichia coli level, oocysts of eimeria and concentrations of salinomycin antibiotic until 90 days. the cp treatment is less efficient for degradation of the salinomycin antibiotic. independent of the treatments, the composting of poultry litter is efficient in elimination of e coli.