alcohol consumption and stress are health problems, which affects the cholinergic muscarinic receptor (cmr) system. here we studied the effect of both phenomena on cmr functionality and densities. methods: 43 sprague dawley rats were divided in 4 groups: control (n=11), stress (n=10), alcohol (n=10) and alcohol-stress (n=9). alcohol groups received 10% ethanol ad libitum in substitution of water every day, stress groups were submitted 3 days at week to 5 min force swimming at 5°c. results: rats that had alcohol displayed addiction and hypermotility, the effect was higher at alcohol-stress group. scopolamine significantly increased motility in all groups. no differences were observed at rotarod performance. cmr density was decreased in hippocampus of rats belonging to alcohol group. conclusion: alcohol induces motor disturbances related to cmr system.