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Purificación parcial de un compuesto presente en las hojas de Bauhinia megalandra capaz de inhibir la absorción intestinal de Glucosa

Keywords: bauhiniamegalandra, intestinal glucose absorption, apigenin, phloricin.

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Abstract:

at present, it has been an increase in the research of the biological activity of plants used by the traditional medicine for the empirical treatment of the diabetes mellitus, such as bauhinia megalandra. the phytochemical study of the leaves of these plants was done guided by bioassay, evaluating the effect of each fraction on the glucose intestinal absorption, using in situ rat intestinal segments. after a sequential series of extractions with organic solvents and fractionation by column chromatographic on silica gel 60, we isolated a fraction characterized by spectroscopic method to be highly enriched in the flavonoid apigenin glicolisated in the carbon eight. this fraction was able to inhibit in a 47,34% the intestinal glucose absorption compared to control, and showed an additive effect when used simultaneously with phloricin.

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