patients with chronic kidney disease may suffer from a chronic infammatory state reflected by the elevation of infammatory markers as c-reactive protein. there is a strong association between clinical complications, malnutrition and infammation in dialysis patients. the terms malnutrition, infammation and atherosclerosis and malnutrition-infammation complex syndrome (mics) have been proposed to indicate the combination of these conditions in these patients. in dialysis patients the protein-energy malnutrition and the infammation are associated with the increase of morbidity and mortality, including increased risk of cardiovascular disease. the subjective global assessment and the malnutrition-infammation score are two tools for assessing protein-energy malnutrition in hemodialysis patients. intradialytic parenteral nutrition is a strategy for safe and appropriate nutrition intervention.