A 49 years old gentleman presented with intermittent bilateral knee swelling for the past 37 years and was eventually diagnosed as primary hypertrophic osteoarthropathy after secondary forms were excluded. This case illustrated that the disease can present during childhood with an insidious onset and progressively becoming more severe and that is when medical attention is sought. Furthermore, the patient did not voluntarily report his skin changes as he considered the slow progressive changes as normal. We report a case of primary hypertrophic osteoarthropathy, its clinical presentation, imaging findings and therapeutic treatment. It is a rare differential diagnosis for pain and chronic joint swelling.
Gómez Rodríguez, N., Ibánez Ruán, J. and González Pérez, M. (2009) Primary Hypertrophic Osteoarthropathy (Pachydermoperiostosis). Report of 2 Familial Cases and Literature Review. Reumatología Clínica, 5, 259-263.
Offret, H., Venencie, P.Y., Fain, J., Quillard, J. and Badarani, N. (1996) Involvement of the Connective Tissue of the Eyelids in Pachydermoperiostosis. Journal Francais D’Ophtalmologie, 19, 64-68. [Article in French].
Kabashima, K., Sakabe, J., Yoshiki, R., Tabata, Y., Kohno, K. and Tokura, Y. (2010) Involvement of Wnt Signaling in Dermal Fibroblasts. The American Journal of Pathology, 176, 721-732. https://doi.org/10.2353/ajpath.2010.090454
Martinez-Lavin, M., Vargas, A. and Rivera-Vinas, M. (2008) Hypertrophic Osteoarthropathy: A Palindrome with a Pathogenic Connotation. Current Opinion in Rheumatology, 20, 88-91. https://doi.org/10.1097/BOR.0b013e3282f14a5a