Objectives: To study the clinical and the histopathological characteristics of gastric cancer concentrating more on the gastric adenocarcinoma. Design: Prospective study of one hundred thirty Yemeni patients confirmed with gastric malignancies during the period from July 2016 to July 2017. Setting: Specialized center of gastrointestinal and liver diseases in Ibb city, Yemen. Subjects: All patients with histopathologically proved gastric cancer. Results: We collect 130 patients with gastric cancer during the study period, they were 93 males and 37 females with age ranged between 25 years and 100 years and the mean age was 64.98 ± 15.15 years. The most frequent clinical presentations of our patients were epigastric pain (81.5%), weight loss (74.6%), dysphagia (46.9%), vomiting (49.2%), palpable epigastric mass (19.2%) and hematemesis/melena (20%). Proximally located gastric cancer represented 46.1%; 48.9% of males patients and 38.9% of females patients. Adenocarcinoma constituted 92.4%, of which the intestinal type was 82.5% and the diffuse type was 17.5%. Squamous cancer accounted in 1.5%, and the non-epithelial tumor was in 6.1%, of which 4.6% were lymphoma and 1.5% were GIST. Conclusion: Adenocarcinomas are the major histological type of gastric cancer and represent 92.4% of all gastric malignancies in which intestinal type represented 82.5% and diffuse type represented 17.5%, and proximally located gastric cancer within stomach was the commonest in both sexes.
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