In the article has developed an optimization mathematical model and methodology of selection of optimal parameters of manipulation of systems of transport and technological machines, which allows to increase their service performance and competitiveness. Also developed the original structure of a comprehensive objective function taking into account the additive effect of any number of important indicators of quality in the formation of the optimal variant of the designed construction. Established the feasibility of using optimization approaches to definition of the basic dimensions of the kinematic scheme and parameters of the drive for the hydraulic manipulation system at the preliminary stage – the stage of development of the technical proposal for the design of the mobile machine. The approach enables the source to lay the subject to further design of the optimal values of the most important quantitative characteristics that determine the realization of the highest values of quality designed manipulation systems. For manipulation systems of hydraulic mobile machine appropriate to use such indicators of quality as its own weight and the capacity of the pumping installation. Pre-design optimization allows to comprehensively determine the optimum combination of a sufficiently large number of basic design parameters – the characteristic dimensions of metal constructions of manipulation systems (lengths, dimensions, cross sections, links, and mounting dimensions for hydraulic drives) and characteristics of the hydraulic equipment (working pressure and flow rate of the working fluid).