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Health  2016 

LDL-Related Intolerance to Glucose, Diastolic Hypertension and Additive Effects of Smoking Were Found with Three Female Study Groups

DOI: 10.4236/health.2016.83026, PP. 230-250

Keywords: Combined Telemedical Care: Women’s Health, Obesity, LDL-Intolerance to Glucose, Diastolic Hypertension, Ratio of Serum Albumin to Triglycerides (Alb/Trig), Albuminuria

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Abstract:

Initial prodiabetic risk profiles were invented here with three female study groups consisting of primarily healthy women (A1: 1990-1999, n = 160; A2: 2009, n = 88; A: n = 248, 36 ± 14 years; B: 2014: n = 65, aged 37± 11 years). Significantly higher blood pressure was found comparing intolerance versus tolerance to glucose (p < 0.05, IGTT, 22 of 68). High LDL-cholesterol (LDL-C) showed additive effects as LDL-related intolerance was further related with rise of blood pressure (p < 0.05), of triglycerides (p = 0.02), of fasting blood glucose (p = 0.07) and of urine pathology (p = 0.07). High LDL-C of women who reported smoking at baseline was correlated with diastolic hypertension whereby alcohol problems overlapped (p = 0.036, A). Unhealthy combinations were found consisting of LDL-related intolerance to glucose, LDL-related smoking, of alcohol-related hypertriglyceridemia or of combined drinking and smoking testing urine pathology over the course of time. Obese women were at direct risk for hypertension in the presence of high LDL-C and submaximal ratio of serum albumin to triglycerides (Alb/Trig). Obese women reacted highly sensitive to critical alcohol consumption showing then macroalbuminuria. Current participants who disowned daily alcohol consumption showed healthy morning urines and normal fasting blood glucose. Mild decrease of HDL-C was observed during heavy smoking of relatively young women who had normal biomarkers. Women with intolerance to glucose were at direct risk for hypertension whereby high LDL-C and/or smoking triggered prodiabetic risk profiles. Obese women had elevated LDL-C during hypertension and reacted highly sensitive to alcohol-related proteinuria and/or hematuria.

References

[1]  Korth, R.M. (2014) Women with Overweight, Mixed Hyperlipidemia, Intolerance to Glucose and Diastolic Hypertension. Health, 6, 454-467.
http://dx.doi.org/10.4236/health.2014.65064
[2]  Korth, R.M. (2006) Gender, Obesity, Alcohol Use, Hyperlipidemia, Hypertension and Decline of Renal Endothelial Barriers. Journal Men’s Health & Gender, 3, 279-289.
http://dx.doi.org/10.1016/j.jmhg.2005.08.006
[3]  Korth, R.M. (2012) Two Male Study Groups with Adiposity and Hypertriglyceridemia Were at Risk for Hypertension. Health, 4, 1390-1395.
http://dx.doi.org/10.4236/health.2012.412A201
[4]  Korth, R.M. (2007) Obesity Mediated Hypertension While Alcohol Use Declined Renal Endothelial Barriers of Women. The FASEB Journal, 21, A1361.
[5]  Korth, R.M. (2002) AHA-Syndromes. Chemistry and Physics of Lipids, 118, 96-97.
[6]  Korth, R.M. (2009) Gender Dyslipidemia and Ether Phospholipids. The FASEB Journal, 19, 109.
[7]  Korth, R., Zimmermann, K. and Richter, W. (1994) Lipoprotein-Associated paf (LA-paf) Was Found in Washed Human Platelets and Monocyte/Macrophage-Like U 937 Cells. Chemistry and Physics of Lipids, 70, 109-119.
http://dx.doi.org/10.1016/0009-3084(94)90079-5
[8]  Korth, R.M. (1997) VLDL and PAF Binding to Human Endothelial Cells. Chemistry and Physics of Lipids, 88, 134.
[9]  Korth, R. (1999) Treatment and Prevention of Disorders Mediated by LA-paf or Endothelial Cells. United States Patent Publication No. 5895785.
[10]  Korth, R.M., Hirafuji, M., Benveniste, J. and Russo-Marie, F. (1995) Human Umbilical Vein Endothelial Cells: Specific Binding of Platelet-Activating Factor and Cytosolic Calcium Flux. Biochem Pharmacol, 49, 1793-1799.
http://dx.doi.org/10.1016/0006-2952(95)00025-U
[11]  Korth, R.M. (1997) Specific Binding Sites for 1-O-Alkyl-sn-Glyceryl-3-Phosphorylcholine on Intact Human Blood Neutrophils. International Archives of Allergy and Immunology, 113, 460-464.
http://dx.doi.org/10.1159/000237623
[12]  Korth, R. and Middeke, M. (1991) Long Time Incubation of Monocytic U 937 Cells with LDL Increase Specific PAF-Acether Binding and the Cellular Acetylhydrolase Activity. Chemistry and Physics of Lipids, 59, 207-213.
http://dx.doi.org/10.1016/0009-3084(91)90020-C
[13]  Korth, R., Bidault, J., Palmantier, R., Benveniste, J. and Ninio, E. (1993) Human Platelets Release a Paf-Acether: Acetylhydrolase Similar to That in Plasma. Lipids, 28, 193-199.
http://dx.doi.org/10.1007/BF02536639
[14]  Korth, R.M. (2000) Comparison of Phosphocholines in Plasma and Cerebrospinal Fluids (CSF). The FASEB Journal, 14, A72.
[15]  Korth, R. and Benveniste, J. (1987) BN 52021 Displaces [3H]paf-Acether from and Inhibits Its Binding to Intact Human Platelets. European Journal of Pharmacology, 142, 331-341.
http://dx.doi.org/10.1016/0014-2999(87)90071-9
[16]  Korth, R., Nunez, D., Bidault, J. and Benveniste, J. (1988) Comparison of Three paf-Acether Receptor Antagonists Ginkgolides. European Journal of Pharmacology, 152, 101-110.
http://dx.doi.org/10.1016/0014-2999(88)90840-0
[17]  Korth, R.M. (2014) Novel compositions against alkyl-acyl-GPC, the derivatives and products thereof. European Patent Publication No. 1965791B1.
[18]  Meade, C.J., Heuer, H. and Kempe, R. (1991) Commentary: Biochemical Pharmacology of Platelet-Activating Factor (and paf Antagonists) in Relation to Clinical and Experimental Thrombocytopenia. Biochemical Pharmacology, 41, 657-668.
[19]  Ihida, K., Predescu, D., Czekay, R.P. and Palade, G.E. (1999) Platelet Activating Factor Receptor (PAF-R) Is Found in a Large Endosomal Compartment in Human Umbilical Vein Endothelial Cells. Journal of Cell Science, 112, 285-295.
[20]  Nistor, A. and Simionescu, M. (1986) Uptake of Low Density Lipoproteins by the Hamster Lung. Interactions with Capillary Endothelium. The American Review of Respiratory Disease, 134, 1266-1272.
[21]  Wu, R., Lemne, C., De Faire, U. and Frostegard, J. (1997) Antibodies to Platelet-Activating Factor Are Associated with Borderline Hypertension, Early Atherosclerosis and the Metabolic Syndrome. Journal of Internal Medicine, 246, 389-397.
http://dx.doi.org/10.1046/j.1365-2796.1999.00570.x
[22]  Me.G., Richard, G. and White, T.W. (2007) Gap Junctions: Basic Structure and Function. Journal of Investigative Dermatology, 127, 2516-2524.
http://dx.doi.org/10.1038/sj.jid.5700770
[23]  Louis, S.F. and Zaharadka, P. (2010) Vascular Smooth Muscle Cell Motility: From Migration to Invasion. Experi- mental & Clinical Cardiology, 15, e75-e85.
[24]  Pizzimenti, S., Ciamporcero, E., Daga, M., Pettazzoni, P., Arcaro, A. Cetrangolo, G., Minelli, R., Dianzani, C., Lepore, A., Gentile, F. and Barrera, G. (2013) Interaction of Aldehydes Derived from Lipid Peroxidation and Membrane Proteins. Frontiers in Physiology, 4, 242.
[25]  van der Vusse, G.J. (2009) Albumin as Fatty Acid Transporter. Drug Metabolism and Pharmacokinetics, 24, 300-307.
http://dx.doi.org/10.2133/dmpk.24.300
[26]  Ambrosio, G., Oriente, A., Napoli, C., Palumbo, G., Chiarello, P., Marone, G., Conorelli, M., Chiariello, M. and Trigginai, M. (1994) Oxygen Radicals Inhibit Plasma Acetylhydrolase, the Enzyme That Catabolized Platelet Activting Factor. Journal of Clinical Investigation, 93, 2408-2416.
http://dx.doi.org/10.1172/JCI117248
[27]  Silva, I.T., Mello, A.P.Q. and Damasceno, N.R.T. (2011) Antioxidant and Inflammatory Aspects of Lipoproteins-Associated Phospholipases A2 (LP-PLA2): A Review. Lipids in Health and Disease, 10, 170-175.
http://dx.doi.org/10.1186/1476-511X-10-170
[28]  Gregson, J., Stirnadel-Farrant, H.A., Doobaree, I. and Koro, C. (2012) Variation of Lipoprotein Associated Phosphoplipases A2 across Demographic Characteristics and Cardiovascular Risk Factors: A Systematic Review of Literature. Atherosclerosis, 225, 11-21.
http://dx.doi.org/10.1016/j.atherosclerosis.2012.06.020
[29]  Patja, K., Jousilahti, P., Hu, G., Valle, T., Quiao, Q. and Tuomilehto, J. (2005) Effects of Smoking, Obesity and Physical Activity on the Risk of Type 2 Diabetes in Middle-Aged Finnish Men and Women. Journal of Internal Medicine, 258, 356-362.
http://dx.doi.org/10.1111/j.1365-2796.2005.01545.x
[30]  Saito, T., Urushihara, M., Kotani, Y., Kagami, S. and Kobori, H. (2009) Increased Urinary Angiotensinogen Is Precedent to Increased Urinary Albumin in Patients with Type 1 Diabetes. The American Journal of the Medical Sciences, 338, 478-480.
http://dx.doi.org/10.1097/MAJ.0b013e3181b90c25
[31]  Dell’Omo, G., Penno, G., Pucci, L., Mariani, M., Del Prato, S. and Pedrinelli, R. (2014) Abnormal Capillary Permeability and Endothelial Dysfunction in Hypertension with Comorbid Metabolic Syndrome. Atherosclerosis, 172, 383-389.
http://dx.doi.org/10.1016/j.atherosclerosis.2003.11.013
[32]  Barzilay, J.J., Peterson, D., Cushman, M., Heckbert, S.R., Cao, J.J., Blaum, C., Tracy, R.P., Klein, R. and Herrington, D.M. (2004) The Relationship of Cardiovascular Risk Factors to Microalbuminuria in Older Adults with or without Diabetes Mellitus or Hypertension: The Cardiovascular Health Study. American Journal of Kidney Diseases, 44, 25-34.
http://dx.doi.org/10.1053/j.ajkd.2004.03.022
[33]  Kristjansson, K., Ljungmann, S., Bengtsson, C., Bjorkel, C. and Sigurdsson, J.A. (2001) Microproteinuria and Long-Term Prognosis with Respect to Renal Function and Survival in Normotensive and Hypertensive Women. Scandinavian Journal of Urology and Nephrology, 35, 63-70.
http://dx.doi.org/10.1080/00365590151030868
[34]  Uribarri, J., Woodruff, S., Goodman, S., Cai, W., Chen, X., Pyzik, R., Yong, A., Striker, G.E. and Vlassara, H. (2010) Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet. Journal of the Academy of Nutrition and Dietetics, 110, 911-916.
http://dx.doi.org/10.1016/j.jada.2010.03.018
[35]  Faure, P., Troncy, L., Lecomte, M., Wiernsperger, N., Lagarde, M., Ruggerio, D. and Halimi, S. (2005) Albumin Antioxidant Capacity Is Modified by Methylglyoxal. Diabetes & Metabolism, 31, 169-177.
http://dx.doi.org/10.1016/S1262-3636(07)70183-0
[36]  Muoio, D.M. (2010) Intramuscular Triacylglycerol and Insulin Resistance: Guilty as Charged or Wrongly Used. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 180, 281-288.
http://dx.doi.org/10.1016/j.bbalip.2009.11.007
[37]  Berenson, G.S., Srinivasan, S.R., Bao, W., Newmann, W.P., Tracy, R.E. and Wattigney, W.A. (1998) Association between Multiple Cardiovascular Risk Factors and Atherosclerosis in Children and Young Adults. The New England Journal of Medicine, 338, 1650-1656.
http://dx.doi.org/10.1056/NEJM199806043382302
[38]  Woo Baidal, J.A. and Taveras, E.M. (2014) Protecting Progress against Childhood Obesity—The National School Lunch Program. The New England Journal of Medicine, 371, 1862-1865.
http://dx.doi.org/10.1056/nejmp1409353
[39]  Volek, J.S., Fernandez, M.L., Feinman, R.D. and Phinney, S.D. (2008) Dietary Carbohydrate Restricition Induces a Unique Metablic State Positively Affecting Atherogenic Dyslipidemia, Fatty Acid Partioning, and Metabolic Syn- drome. Progress in Lipid Research, 47, 307-318.
http://dx.doi.org/10.1016/j.plipres.2008.02.003
[40]  Shufelt, C.J. and Merz, N.B. (2009) Contraceptive Hormone Use and Cardiovascular Disease. State-of-the-Art-Paper. Journal of the American College of Cardiology, 53, 221-231.
http://dx.doi.org/10.1016/j.jacc.2008.09.042
[41]  Georgieva, A.M., Cate, H.T., Keulen, E.T.P., van Oerle, R., Govers-Riemslag, J.W.G., Hamulyak, K., van der Kallen, C.J.H., van Greevenbrock, M.M.J. and de Bruin, T.W.A. (2004) Prothrombotic Markers of Familial Combined Hyperlipidemia. Evidence of Endothelial Cell Activation and Relation to Metabolic Syndrome. Atherosclerosis, 175, 345-351.
http://dx.doi.org/10.1016/j.atherosclerosis.2004.04.006
[42]  Heydarkhan-Hagvall, S., Helenius, G., Johansson, B.R., Li, J.Y., Mattson, E. and Risberg, B. (2003) Co-Culture of Endothelial Cells and Smooth Muscle Cells Affects Gene Expression of Angioneic Factors. Journal of Cellular Biochemistry, 89, 1250-1259.
http://dx.doi.org/10.1002/jcb.10583
[43]  Canaud, G., Bienaime, F., Tabarin, F., Bataillon, G., Seilhean, D., Noel, L.H, Dragon-Durey, M.L., Snanoudi, R., Friedlander, G., Halbwacgs-Mecarelli, L., Legendre, C. and Terzi, F. (2014) Inhibition of the mTORC Pathway in the Antiphospholipid Syndrome. The New England Journal of Medicine, 371, 303-312.
http://dx.doi.org/10.1056/NEJMoa1312890
[44]  Sacks, F.M., Svetkey, L.P., Vollmer, W.M., Appel, L.J., Bray, G.A., Harsha, D., Obarzanek, E., Conlin, P.R., Miller, E.R., Simons-Morton, D.G., Karanja, N., Lin, P.-H., et al., DASH-Sodium Collaboration Research Group (2001) Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet. The New England Journal of Medicine, 344, 3-10.
http://dx.doi.org/10.1056/NEJM200101043440101
[45]  Salmon, A.H.J., Ferguson, J.K., Burford, J.L., Gevorgyan, H., Nakiano, D., Harper, S.J., Bates, D.O. and Peti-Peterdi, J. (2012) Loss of the Endothelial Glycocalyx Links Albuminuria and Vascular Dysfunction. Journal of the Amercian Society of Nephrology, 23, 1339-1350.
http://jasn.asnjournals.org
[46]  Man, R.Y.K. (1988) Lysophosphatidylcholine-Induced Arrhythmias and Its Accumulation in the Rat Perfused Heart. British Journal of Pharmacology, 93, 412-416.
http://dx.doi.org/10.1111/j.1476-5381.1988.tb11448.x
[47]  Chen, Y., Zhang, H., Zhang, Y., Lu, N., Zhang, L. and Shi, L. (2015) Exercise Intensity-Dependent Reverse and Adverse Remodeling of Voltage-Gated Ca2+ Channels in Mesenteric Arteries from Spontaneously Hypertensive Rats. Hypertension Research, 38, 656-665.
http://dx.doi.org/10.1038/hr.2015.56
[48]  Dominiczak, A.F., Negrim, D.C., Clark, J.S., Brosnan, J., McBride, M.W. and Alexander, M.Y. (2000) State-of-the- Art Lectures: Genes and Hypertension. Hypertension, 35, 164-172.
http://dx.doi.org/10.1161/01.HYP.35.1.164
[49]  Nebte, A., O’Donnell, M.J., Rangarajan, S., McQueen, M.J., Poirier, P., et al. (2014) Association of Urinary Sodium and Potassium Excretion with Blood Pressure. The New England Journal of Medicine, 371, 601-611.
http://dx.doi.org/10.1056/NEJMoa1311989
[50]  Furukawa, M., Narahara, H., Yasuda, K. and Johnston, J. (1993) Presence of Platelet-Activating Factor-Acetylhydro- lase in Milk. The Journal of Lipid Research, 34, 1603-1609.
[51]  Fruhwirth, B. and Hermetter, A. (2007) Seeds and Oil of the Syrian Oil Pumpkin: Components and Biological Activities. European Journal of Lipid Science and Technology, 109, 1128-1140.
http://dx.doi.org/10.1002/ejlt.200700105
[52]  Korth, R.M. (2003) Alcohol, Obesity, Hypertension and Endothelial Irritation. The FASEB Journal, 17, 4-5.
[53]  Korth, R.M. (2006) Association of Intolerance to Glucose with Rising Blood Pressure or Proteinuria/Hematuria. Journal of Vascular Research, 43, S90.
[54]  Korth, R.M. (2007) PO3-59 Smoking, Borderline LDL Levels and Renal Small Vessel Disease of Women with Overweight. Atherosclerosis Supplements, 8, 32-33.
http://dx.doi.org/10.1016/S1567-5688(07)71069-3
[55]  Korth, R.M. (2008) Aging Women with LDL-Related Borderline Syndromes. Chemistry and Physics of Lipids, 154, S47-S48.
http://dx.doi.org/10.1016/j.chemphyslip.2008.05.129
[56]  Chopra, S., Cherian, D. and Jacob, J.J. (2011) The Thyroid Hormone, Parathyroid Hormone and Vitamin D Associated Hypertension. Indian Journal of Endocrinology and Metabolism, 15, S354-S360.
[57]  Evans, R. (1988) The Steroid and Thyroid Hormone Receptor Superfamily. Science, 240, 889-895.
http://dx.doi.org/10.1126/science.3283939
[58]  Visser, M., Bouter, L.M., McQuillan, G.M., Wener, M.H. and Harris, T.B. (1990) Elevated C-Reactive Protein Level in Overweight and Obese Adults. JAMA, 282, 2131-2135.
[59]  Kraus, A.R. (2008) Alkoholkonsum, alkoholbezogene Probleme und Trends. Ergebnisse des epidemiologischen Suchtsurvy 2003. Robert Koch Institut, Gesundheitsberichterstattung des Bundes 2008, Heft 40.
[60]  Go, A.S., Chertow, G.M., Fan, D., McCulloch, C.E. and Hsu, C.Y. (2004) Chronic Kidney Disease and the Risks of Death, Cardiovascular Events and Hospitalization. The New England Journal of Medicine, 351, 1296-1305.
http://dx.doi.org/10.1056/NEJMoa041031
[61]  Sava, L., Pillai, S., More, U. and Sontakke, A. (2005) Serum Calcium Measurement: Total versus Free (Ionized) Calcium. Indian Journal of Clinical Biochemistry, 20, 158-161.
http://dx.doi.org/10.1007/BF02867418
[62]  Cook, N.R. and Ridker, P.M. (2014) Further Insight into Cardiovascular Risk Calculator: The Roles of Statins, Revascularizations and Underascertainment in the Women’s Health Study. JAMA Internal Medicine, 174, 1964-1971.
http://dx.doi.org/10.1001/jamainternmed.2014.5336
[63]  Chapman, M.J., Ginsberg, H.N., Amareno, P., et al. (2011) Triglyceride-Rich Lipoproteins and High-Density Lipoprotein Cholesterol in Patients at High Risk of Cardiovascular Disease: Evidence and Guidance for Management. European Heart Journal, 32, 1345-1361.
http://dx.doi.org/10.1093/eurheartj/ehr112
[64]  Bartz, R., Li, W.H., Venable, B., Zehmer, J.K., Welti, M.R., Aderson, R.G.W., Liu, P. and Chapman, K.D. (2007) Lipidomics Reveal That Adiposome Store Ether Lipids and Mediate Phospholipid Traffic. The Journal of Lipid Research, 48, 837-847.
http://dx.doi.org/10.1194/jlr.M600413-JLR200
[65]  Vergeer, M., Holleboom, A.G., Kastelein, J.J.P. and Kuivenhoven, J.A. (2010) The HDL Hypothesis: Does High-Density Lipoprotein Protect from Atherosclerosis. The Journal of Lipid Research, 51, 2058-2073.
http://dx.doi.org/10.1194/jlr.R001610
[66]  Lamarche, B. and Paradi, M.E. (2007) Endothelial Lipase and the Metabolic Syndrome. Current Opinion in Lipidology, 18, 298-303.
http://dx.doi.org/10.1097/MOL.0b013e328133857f
[67]  Slattery, C., Zhang, L.A., Kelly, D.J., Thorn, P., Nikolic-Paterson, D.J., Tesch, G.H. and Poronnik, P. (2008) In Vivo Visualization of Albumin Degradation in the Proximal Tubule. Kidney International, 74, 1480-1486.
http://dx.doi.org/10.1038/ki.2008.463
[68]  Osicka, T.M., Panagiotopoulos, S., Jerums, G. and Comper, W.D. (1997) Fractional Clearance of Albumin Is Influenced by Its Degradation during Renal Passage. Clinical Science, 93, 557-564. http://dx.doi.org/10.1042/cs0930557
[69]  Bond, H., Sibley, C.P., Balment, R.J. and Ashton, N. (2005) Increased Renal Tubular Reabsorbation of Calcium and Magnesium by the Offspring of Diabetic Rat Pregnancy. Pediatric Research, 57, 890-895.
http://dx.doi.org/10.1203/01.PDR.0000157720.50808.97
[70]  Savige, J., Rana, K., Tonna, S., Buzza, M., Daghar, H. and Wang, Y.Y. (2003) Thin Basement Membrane Nephropathy. Kidney Inernational, 64, 1169-1178.
http://dx.doi.org/10.1046/j.1523-1755.2003.00234.x
[71]  Collar, J.R., Ladva, S., Cairns, T.D. and Cattell, V. (2001) Red Cell Traverse through Thin Glomerular Basement Membranes. Kidney International, 59, 2069-2072.
[72]  Jacob, M., Bruegger, D., Rehm, M., Stoeckelhuber, M., Welsch, U., Conzen, P. and Becker, B.F. (2007) The Endothelial Glycocalyx Affords Compatibility of Starling’s Principle and High Cardiac Interstitial Albumin Levels. Cardiovascular Research, 73, 575-586.
http://dx.doi.org/10.1016/j.cardiores.2006.11.021
[73]  Shukla, A., Grisouard, J., Ehemann, V., Hermani, A., Enzmann, H. and Mayer, D. (2009) Analysis of Signaling Pathways Related to Cell Proliferation Stimulated by Insulin Analogs in Human Mammary Epithelial Cell Lines. Endocrine-Related Cancer, 16, 429-441.
http://dx.doi.org/10.1677/ERC-08-0240
[74]  Waterworth, D.M., Talmud, P.J., Luan, J., Flavell, D.M., Byrne, C.E., Humphries, S.E. and Wareham, N.J. (2003) Variants in the APOC3 Promoter Insulin Responsive Element Modualte Secretion and Lipids in Middle-Aged Men. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1637, 200-206.
http://dx.doi.org/10.1016/S0925-4439(03)00021-8
[75]  The TG and HDL Working Group of the Exome Sequencing Project, National-Heart, Lung and Blood Institute (2014) Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease. The New England Journal of Medicine, 371, 22-31.
http://dx.doi.org/10.1056/NEJMoa1307095
[76]  Fouchier, S.W., Sankatsing, J., Peter, J., Castillo, S., Pocovi, M., Alonos, R., Kastelein, J.J.P. and Defesche, J.C. (2005) High Frequency of APOB Gene Mutations Causing Familial Hypobetalipoproteinaemia in Patients of Dutch and Spanish Descent. Journal of Medical Genetics, 42, e23.
[77]  Chen, P., Jou, Y.-S., Fann, C.S., Chen, J.-W., Chung, C.-M., Lin, C.-Y., Wu, S.-Y., Kang, M.-J., Chen, Y.-C., Jong, Y.-S., Lo, H.-M., Kang, C.-S., Chen, C.-C., Chang, H.-C., Huangk, N.-K., Wu, Y.-L. and Pan, W.-H. (2009) Lipoprotein Lipase Variants Associated with an Endophenotype of Hypertension: Hypertension Combined with Elevated Triglycerides. Human Mutation, 30, 49-55.
http://dx.doi.org/10.1002/humu.20812
[78]  Hiramoto, M., Yoshida, H., Imaizumi, T., Yoshimizu, N. and Satoh, K. (1997) A Mutation in Plasma Platelet Activating Factor Acetylhydrolase (Val279-Phe) Is a Genetic Risk Factor for Stroke. Stroke, 28, 2417-2420.
http://dx.doi.org/10.1161/01.STR.28.12.2417
[79]  Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennachio, L.A., Boerwinkle, E., Cohen, J. and Hobbs, H. (2008) Genetic Variation in PNPLA3 Confers Susceptibility to Nonalcoholic Fatty Liver Disease. Nature Genetics, 40, 1461-1465.
http://dx.doi.org/10.1038/ng.257
[80]  Cichoz-Lach, H., Partyck, J., Nesina, I., Celinski, K., Slomka, M. and Wojcierowsli, J. (2007) Alcohol Dehydrogenase and Aldehyde Dehydrogenase Gene Polymorphism in Alcohol Liver Cirrhosis and Alcohol Chronic Pancreatitis among Polish Individuals. Scandinavian Journal of Gastroenterology, 42, 493-498.
http://dx.doi.org/10.1080/00365520600965723
[81]  The ACCORD Study Groupand ACCORD Eye Study Group (2010) Effects of Medical Therapies on Retinopathy Progression in Type 2 Diabetes. The New England Journal of Medicine, 363, 233-244.
http://dx.doi.org/10.1056/NEJMoa1001288
[82]  Winkler, K., Abletshauser, C., Friedrich, I., Hoffmann, M.M., Wieland, H. and Marz, W. (2004) Fluvastatin Slow-Release Lowers Platelet-Activating Factor Acetylhydrolase Activity: A Placebo-Controlled Trial in Patients with Type 2 Diabetes. The Journal of Clinical Endocrinology & Metabolism, 89, 1153-1159.
http://dx.doi.org/10.1210/jc.2003-031494
[83]  Cole, P. and Rabassada, X. (2005) Enhanced Hypercholesterolemia Therapy: The Ezetimibe/Simvastatin Tablet. Drugs Today, 41, 317-327.
http://dx.doi.org/10.1358/dot.2005.41.5.893614
[84]  Weingartner, O., Bohm, M. and Lauf, U. (2009) Controversial Role of Plant Sterols Esters in the Management of Hypercholestrolemia. European Heart Journal, 40, 404-409.
[85]  Brand-Herrmann, S.M., Kuznetsova, T., Wiechert, A., Stolarz, K., Tikhonoff, V., Schmidt-Peterson, K., Telgmann, R., Casiglia, E., Wang, J.G., Thijs, L., Staessen, J.A. and Brand, E. (2005) Alcohol Intake Modulates the Genetic Association between HDL Cholesterol and the PPARγ2 Pro12Ala Polymorphism. The Journal of Lipid Research, 46, 913-919.
http://dx.doi.org/10.1194/jlr.M400405-JLR200
[86]  Davies, S.S., Pontsler, A.V., Marathe, G.K., Harrison, K.A., Murphy, R.C., Hinshaw, J.C., Prestwich, G.D., Hilaire, A.S.T., Prescott, S.M., Zimmerman, G.A. and McIntyre, T.M. (2001) Oxidized Alkyl Phospholipids Are Specific High Affinity Peroxisome Proliferator-Activated Receptor γ Ligands and Agonists. The Journal of Biological Chemistry, 276, 16015-16023.
http://dx.doi.org/10.1074/jbc.M100878200
[87]  Cepeda-Benito, A., Reynoso, J.T. and Erath, S. (2004) Meta-Analysis of the Efficacy of Nicotine Replacement Therapy for Smoking Cessation: Differences between Men and Women. Journal of Consulting and Clinical Psycho- logy, 72, 712-722.
http://dx.doi.org/10.1037/0022-006X.72.4.712
[88]  Song, W., Wang, L., Dou, L.-Y., Wang, Y., Xu, Y., Chen, L.F. and Yan, X.W. (2015) The Implication of Cigarette Smoking and Cessation on Macrophage Cholesterol Efflux in Coronary Artery Disease Patients. The Journal of Lipid Research, 56, 682-691.
http://dx.doi.org/10.1194/jlr.P055491
[89]  Bundeszentrale für gesundheitliche Aufklarung. Internet Presentation 2015. www.rauchfreiinfo.de
[90]  Vulimir, S.V., Misa, M., Hamm, J.T., Mitchell, M. and Berger, A. (2009) Effects of Mainstream Cigarette Smoke on the Global Metabolome of Human Lung Epithelial Cells. Chemical Research in Toxicology, 22, 492-503.
http://dx.doi.org/10.1021/tx8003246
[91]  Fragerstrom, K. and Aubin, H.J. (2009) Management of Smoking Cessation in Patients with Psychiatric Disorders. Current Medical Research and Opinion, 25, 511-518.
http://dx.doi.org/10.1185/03007990802707568

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