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华西医学  2014 

盐酸氨基葡萄糖与双醋瑞因治疗骨关节炎的临床对照研究

DOI: 10.7507/1002-0179.20140339, PP. 1111-1114

Keywords: 盐酸氨基葡萄糖,双醋瑞因,骨关节炎

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Abstract:

目的 比较盐酸氨基葡萄糖与双醋瑞因治疗骨关节炎(OA)的疗效及安全性。方法 选取2011年1月-2012年3月120例OA患者,随机分为盐酸氨基葡萄糖组(A组)、双醋瑞因组(B组)和盐酸氨基葡萄糖联合双醋瑞因组(C组),治疗12周后观察治疗前后临床疗效和安全性。结果 3组患者治疗后较治疗前在20m步行痛、关节触痛、采用西方安大略和麦克马斯特大学骨关节炎指数评分(WOMAC)的骨关节炎指数和健康状况均有明显改善(P<0.05);3组停药1个月后上述指标与治疗结束时相比差异无统计学意义(P>0.05);C组患者改善率优于A、B组(P<0.05);3组患者不良反应发生率差异无统计学意义(P>0.05),均未出现严重不良反应。结论 盐酸氨基葡萄糖与双醋瑞因单用治疗OA疗效和安全性相当,联合应用可取得比单用更好的疗效。

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