Malignant peripheral nerve sheath tumor is a rare soft tissue sarcoma. Breast is an extremely rare location of this lesion and presentation as a breast lump in the absence of pain or previous benign neural tumor is even rarer. We report such a lesion in a 60 year-old female who presented with hard and painless breast lump for 2 years. Histopathology revealed a malignant spindle cell tumor of low grade potential. It was subsequently confirmed to be malignant peripheral nerve sheath tumor (MPNST) on the basis of immunopositivity for vimentin, neurone specific enolase and S-100.
B. S. Ducatman, B. W. Scheithauer, D. G. Piepgras, H. M. Reiman and D. M. Ilstrup, “Malignant Peripheral Nerve Sheath Tumours: A Clinicopathologic Study of 120 Cases,” Cancer, Vol. 57, No. 10, May 1986, pp. 2006-2021.
J. M. Baehring, R. A. Betensky and T. T. Batchelor, “Malignant Peripheral Nerve Sheath Tumour: The Cli- nical Spectrum and Outcome of Treatment,” Neurology, Vol. 61, No. 5, September 2003, pp. 696-698.
J. M. Yi, E. J. Moon, S. J. Oh, A. Lee , Y. J. Suh, J. M. Baek, S. H. Choi and S. S. Jung, “Malignant Peripheral Nerve Sheath Tumor of the Breast in a Patient without Neurofibromatosis: A Case Report,” Journal of breast cancer, Vol. 12, No. 3, September 2009, pp. 223-226.
O. H. Woo, H. S. Yong, J. B. Lee, A. Kim, B.H. Koo and E. Y. Kang, “A Giant Malignant Peripheral Nerve Sheath Tumour of the Breast: CT and Pathological Findings,” British Journal of Radiology, Vol. 80, No. 950, 2007, pp. 44-47. doi:10.1259/bjr/30984808
W. B. Laskin, T. A. Silverman and F. M. Enzinger, “Postradiation Soft Tissue Sarcomas. An Analysis of 53 Cases,” Cancer, Vol. 62, No. 11, December 1988, pp. 2330-2340.
S. Malas, H. E. Krawitz, R. K. Sur, R. R. Uijs, S. J. Nayler and C. V. Levin, “Von Recklinghausen’s Disease Associated with a Primary Malignant Schwannoma of the Breast,” Journal of Surgical Oncolgy, Vol. 59, No. 4,
August 1995, pp. 273-275. doi:10.1002/jso.2930590415
K. K. Dhingra, S. Mandal, S. Roy and N. Khurana, “Malignant Peripheral Nerve Sheath Tumor of the Breast: Case Report,” World Journal of Surgical Oncology, Vol. 5, 2007, p. 142. doi:10.1186/1477-7819-5-142
R. Berrada, A. Chahtane, A. Lakhdar, Z. Elhanchi, D. Ferhati, A. Baidada, A. Kharbach, F. Kettani and A. Chaoui, “Malignant Schwannoma of the Breast. A Case Report,” Journal of Gynecology Obstetrics Biology and Reproduction, Vol. 27, 1998, pp. 441-444.
C. Thanapaisal, S. Koonmee and S. Siritunyaporn, “Malignant Peripheral Nerve Sheath Tumor of Breast in Patient without von Recklinghausen’s Neurofibromatosis: A Case Report,” Journal of Medical Association of Thailand, Vol. 89, No. 3, march 2006, pp. 377-379.