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Physical Activity and Blood Lipids and Lipoproteins in Dialysis Patients

DOI: 10.1155/2012/106914

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The relationship between physical activity and blood lipids and lipoproteins in dialysis patients is reviewed in the context of the potentially confounding factors such as nutritional intake, cigarette smoking, obesity, alcohol intake, and physical activity levels in the general population and additional confounding factors such as mode of dialysis and diabetes in dialysis patients. The known associations in the general population of physical activity with high-density-lipoprotein cholesterol subfractions and apolipoprotein A-I are more pronounced in hemodialysis patients than in peritoneal dialysis patients even after adjusting for these confounding factors. Examining studies on the effects of physical activity on blood lipids and lipoproteins, the most consistent observation is the noted decrease in triglycerides and increase in high-density-lipoprotein cholesterol and insulin sensitivity in hemodialysis patients. The changes in lipids and lipoproteins in hemodialysis patients could be caused by changes in activity levels of lipoprotein lipase, insulin sensitivity, and/or glucose metabolism. Future research investigating the relationship between physical activity and blood lipids and lipoproteins in dialysis patients should direct research towards the underlying mechanisms for changes in blood lipids and lipoproteins. 1. Introduction Atherosclerotic heart disease is the leading cause of mortality among patients with chronic kidney disease [1–3]. Chronic kidney disease is associated with dyslipidemia, which seems to persist as renal failure advances and continues to affect clinical outcomes in patients on hemodialysis (HD) and peritoneal dialysis (PD) [4–13]. Patients on HD and PD are at increased risk for atherosclerotic heart disease, which is due at least in part to atherogenic lipid and lipoprotein abnormalities [1]. One study [14] compared traditional atherosclerotic heart disease risk factors among new dialysis patients with those in the general population and reported that the dialysis patients had a high prevalence of diabetes, hypertension, low physical activity, low high-density-lipoprotein cholesterol (HDL-C), and high triglycerides (TG). Exercise capacity as measured by maximal oxygen uptake in HD and PD patients is lower than in sedentary normal controls [15], but dialysis patients regardless of the treatment mode could benefit from appropriate exercise training in order to increase physical working capacity [16–18]. The positive association of physical activity with HDL-C has been reported in the general population [19–21]. Although a

References

[1]  S. S. Prichard, “Impact of dyslipidemia in end-stage renal disease,” Journal of the American Society of Nephrology, vol. 14, no. 9, supplement 4, pp. S315–S320, 2003.
[2]  R. N. Foley, P. S. Parfrey, and M. J. Sarnak, “Epidemiology of cardiovascular disease in chronic renal disease,” Journal of the American Society of Nephrology, vol. 9, no. 12, supplement, pp. S16–S23, 1998.
[3]  C. A. Herzog, J. Z. Ma, and A. J. Collins, “Poor long-term survival after acute myocardial infarction among patients on long-term dialysis,” The New England Journal of Medicine, vol. 339, no. 12, pp. 799–805, 1998.
[4]  E. Kimak and J. Solski, “ApoA- and apoB-containing lipoproteins and Lp(a) concentration in non-dialyzed patients with chronic renal failure,” Renal Failure, vol. 24, no. 4, pp. 485–492, 2002.
[5]  T. Shoji, Y. Nishizawa, T. Kawagishi et al., “Atherogenic lipoprotein changes in the absence of hyperlipidemia in patients with chronic renal failure treated by hemodialysis,” Atherosclerosis, vol. 131, no. 2, pp. 229–236, 1997.
[6]  G. Monzani, F. Bergesio, R. Ciuti et al., “Lipoprotein abnormalities in chronic renal failure and dialysis patients,” Blood Purification, vol. 14, no. 3, pp. 262–272, 1996.
[7]  M. R. Yi?ito?lu, M. F. Polat, F. Ak?ay, Z. Ari, B. S. Uyanik, and H. M. ?zilgili, “Increased lipoprotein (a) and its relationships with other parameters of lipoprotein metabolism in chronic renal failure treated by hemodialysis,” Japanese Heart Journal, vol. 38, no. 1, pp. 83–89, 1997.
[8]  T. Sakurai, T. Oka, H. Hasegawa, N. Igaki, S. Miki, and T. Goto, “Comparison of lipids, apoproteins and associated enzyme activities between diabetic and nondiabetic end-stage renal disease,” Nephron, vol. 61, no. 4, pp. 409–414, 1992.
[9]  E. Kimak, J. Solski, L. Janicka, A. Ksaziek, and K. Janicki, “Concentration of Lp(a) and other apolipoproteins in predialysis, hemodialysis, chronic ambulatory peritoneal dialysis and post-transplant patients,” Clinical Chemistry and Laboratory Medicine, vol. 38, no. 5, pp. 421–425, 2000.
[10]  K. C. Siamopoulos, M. S. Elisaf, H. T. Bairaktari, M. B. Pappas, G. D. Sferopoulos, and N. G. Nikolakakis, “Lipid parameters including lipoprotein (a) in patients undergoing CAPD and hemodialysis,” Peritoneal Dialysis International, vol. 15, no. 8, pp. 342–347, 1995.
[11]  P. O. A. Attman, O. G. Samuelsson, J. Moberly et al., “Apolipoprotein B-containing lipoproteins in renal failure: the relation to mode of dialysis,” Kidney International, vol. 55, no. 4, pp. 1536–1542, 1999.
[12]  T. Shoji, Y. Nishizawa, H. Nishitani, M. Yamakawa, and H. Morii, “Impaired metabolism of high density lipoprotein in uremic patients,” Kidney International, vol. 41, no. 6, pp. 1653–1661, 1992.
[13]  J. B. Moberly, P. O. Attman, O. Samuelsson, A. C. Johansson, C. Knight-Gibson, and P. Alaupovic, “Alterations in lipoprotein composition in peritoneal dialysis patients,” Peritoneal Dialysis International, vol. 22, no. 2, pp. 220–228, 2002.
[14]  J. C. Longenecker, J. Coresh, N. R. Powe et al., “Traditional cardiovascular disease risk factors in dialysis patients compared with the general population: the CHOICE study,” Journal of the American Society of Nephrology, vol. 13, no. 7, pp. 1918–1927, 2002.
[15]  P. Painter, D. Messer-Rehak, P. Hanson, et al., “Exercise capacity in hemodialysis, CAPD, and renal transplant patients,” Nephron, vol. 42, no. 1, pp. 47–51, 1986.
[16]  P. Koufaki, T. H. Mercer, P. F. Naish, et al., “Effects of exercise training on aerobic and functional capacity of end-stage renal disease patients,” Clinical Physiology and Functional Imaging, vol. 22, no. 2, pp. 115–124, 2002.
[17]  A. Deligiannis, E. Kouidi, E. Tassoulas, P. Gigis, A. Tourkantonis, and A. Coats, “Cardiac effects of exercise rehabilitation in hemodialysis patients,” International Journal of Cardiology, vol. 70, no. 3, pp. 253–266, 1999.
[18]  E. Konstantinidou, G. Koukouvou, E. Kouidi, A. Deligiannis, and A. Tourkantonis, “Exercise training in patients with end-stage renal disease on hemodialysis: comparison of three rehabilitation programs,” Journal of Rehabilitation Medicine, vol. 34, no. 1, pp. 40–45, 2002.
[19]  M. Yao, A. H. Lichtenstein, S. B. Roberts et al., “Relative influence of diet and physical activity on cardiovascular risk factors in urban Chinese adults,” International Journal of Obesity, vol. 27, no. 8, pp. 920–932, 2003.
[20]  O. H. Forde, D. S. Thelle, E. Arnesen, and O. D. Mjos, “Distribution of high density lipoprotein cholesterol according to relative body weight, cigarette smoking and leisure time physical activity,” Acta Medica Scandinavica, vol. 219, no. 2, pp. 167–171, 1986.
[21]  K. Yano, D. M. Reed, J. D. Curb, et al., “Biological and dietary correlates of plasma lipids and lipoproteins among elderly Japanese men in Hawaii,” Arteriosclerosis, vol. 6, no. 4, pp. 422–433, 1986.
[22]  R. Masuda, H. Imamura, K. Mizuuchi, K. Miyahara, H. Kumagai, and H. Hirakata, “Physical activity, high-density lipoprotein cholesterol subfractions and lecithin: cholesterol acyltransferase in dialysis patients,” Nephron Clinical Practice, vol. 111, no. 4, pp. c253–c259, 2009.
[23]  A. P. Goldberg, J. M. Hagberg, J. A. Delmez, et al., “Metabolic effects of exercise training in hemodialysis patients,” Kidney International, vol. 18, no. 6, pp. 754–761, 1980.
[24]  A. P. Goldberg, J. M. Hagberg, J. A. Delmez, et al., “The metabolic and psychological effects of exercise training in hemodialysis patients,” American Journal of Clinical Nutrition, vol. 33, no. 7, pp. 1620–1628, 1980.
[25]  A. P. Goldberg, E. M. Geltman, J. M. Hagberg, et al., “Therapeutic benefits of exercise training for hemodialysis patients,” Kidney International, vol. 24, no. 16, pp. S-303–S-309, 1983.
[26]  D. Mozaffarian, A. Ascherio, F. B. Hu et al., “Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men,” Circulation, vol. 111, no. 2, pp. 157–164, 2005.
[27]  R. N. Lemaitre, I. B. King, D. Mozaffarian, L. H. Kuller, R. P. Tracy, and D. S. Siscovick, “N-3 polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: The Cardiovascular Health Study,” American Journal of Clinical Nutrition, vol. 77, no. 2, pp. 319–325, 2003.
[28]  J. L. Breslow, “N-3 Fatty acids and cardiovascular disease,” American Journal of Clinical Nutrition, vol. 83, no. 6, supplement, pp. 1477S–1482S, 2006.
[29]  F. B. Hu, L. Bronner, W. C. Willett et al., “Fish and omega-3 fatty acid intake and risk of coronary heart disease in women,” Journal of the American Medical Association, vol. 287, no. 14, pp. 1815–1821, 2002.
[30]  T. Nakamura, A. Azuma, T. Kuribayashi, H. Sugihara, S. Okuda, and M. Nakagawa, “Serum fatty acid levels, dietary style and coronary heart disease in three neighbouring areas in Japan: the Kumihama study,” British Journal of Nutrition, vol. 89, no. 2, pp. 267–272, 2003.
[31]  S. M. Grundy and M. A. Denke, “Dietary influences on serum lipids and lipoproteins,” Journal of Lipid Research, vol. 31, no. 7, pp. 1149–1172, 1990.
[32]  L. Djoussé, D. K. Arnett, H. Coon, M. A. Province, L. L. Moore, and R. C. Ellison, “Fruit and vegetable consumption and LDL cholesterol: The National Heart, Lung, and Blood Institute Family Heart Study,” American Journal of Clinical Nutrition, vol. 79, no. 2, pp. 213–217, 2004.
[33]  R. B. Singh, S. S. Rastogi, M. A. Niaz, S. Ghosh, R. Singh, and S. Gupta, “Effect of fat-modified and fruit- and vegetable-enriched diets on blood lipids in the Indian Diet Heart Study,” American Journal of Cardiology, vol. 70, no. 9, pp. 869–874, 1992.
[34]  R. B. Singh, S. Ghosh, and R. Singh, “Effects on serum lipids of adding fruits and vegetables to prudent diet in the Indian experiment of infarct survival (IEIS),” Cardiology, vol. 80, no. 3-4, pp. 283–293, 1992.
[35]  A. T. Merchant, S. S. Anand, L. E. Kelemen et al., “Carbohydrate intake and HDL in a multiethnic population,” American Journal of Clinical Nutrition, vol. 85, no. 1, pp. 225–230, 2007.
[36]  N. M. McKeown, J. B. Meigs, S. Liu et al., “Dietary carbohydrates and cardiovascular disease risk factors in the Framingham offspring cohort,” Journal of the American College of Nutrition, vol. 28, no. 2, pp. 150–158, 2009.
[37]  H. Imamura, K. Tanaka, C. Hirae et al., “Relationship of cigarette smoking to blood pressure and serum lipids and lipoproteins in men,” Clinical and Experimental Pharmacology and Physiology, vol. 23, no. 5, pp. 397–402, 1996.
[38]  H. Imamura, K. Teshima, N. Miyamoto, and T. Shirota, “Cigarette smoking, high-density lipoprotein cholesterol subfractions, and lecithin: cholesterol acyltransferase in young women,” Metabolism, vol. 51, no. 10, pp. 1313–1316, 2002.
[39]  H. Imamura, K. Uchida, and D. Kobata, “Relationship of cigarette smoking with blood pressure, serum lipids and lipoproteins in young Japanese women,” Clinical and Experimental Pharmacology and Physiology, vol. 27, no. 5-6, pp. 364–369, 2000.
[40]  H. Imamura, K. Miyahara, A. Nagata, et al., “Cigarette smoking, HDL-C subfractions, and lecithin:cholesterol acyltransferase in collegiate men,” Health Evaluation and Promotion, vol. 39, pp. 535–539, 2012.
[41]  J. R. Ortlepp, J. Metrikat, M. Albrecht, P. Maya-Pelzer, H. Pongratz, and R. Hoffmann, “Relation of body mass index, physical fitness, and the cardiovascular risk profile in 3127 young normal weight men with an apparently optimal lifestyle,” International Journal of Obesity, vol. 27, no. 8, pp. 979–982, 2003.
[42]  N. Nakanishi, K. Nakamura, S. Ichikawa, K. Suzuki, and K. Tatara, “Relationship between lifestyle and serum lipid and lipoprotein levels in middle-aged Japanese men,” European Journal of Epidemiology, vol. 15, no. 4, pp. 341–348, 1999.
[43]  H. Schr?der, J. Marrugat, R. Elosua, and M. I. Covas, “Relationship between body mass index, serum cholesterol, leisure-time physical activity, and diet in a Mediterranean Southern-Europe population,” British Journal of Nutrition, vol. 90, no. 2, pp. 431–439, 2003.
[44]  A. Taniguchi, M. Fukushima, M. Sakai et al., “The role of the body mass index and triglyceride levels in identifying insulin-sensitive and insulin-resistant variants in Japanese non-insulin-dependent diabetic patients,” Metabolism, vol. 49, no. 8, pp. 1001–1005, 2000.
[45]  T. Kamihama, H. Imamura, C. Nishimura, et al., “Relationship between body mass index and blood pressure, serum lipids and lipoproteins in young Japanese women,” Health Evaluation Promotion, vol. 29, pp. 519–521, 2002 (Japanese).
[46]  T. Kamihama, H. Imamura, C. Nishimura, et al., “Relationship between body mass index and blood pressure, serum lipids and lipoproteins in young Japanese men,” Health Evaluation Promotion, vol. 29, pp. 592–595, 2002 (Japanese).
[47]  H. Imamura, M. Matsubara, M. Minayoshi, et al., “A criterion for evaluation of obesity based on the relationship between percent body fat and medical examination parameters,” The Japanese Journal of Physical Fitness and Sports Medicine, vol. 41, pp. 70–78, 1992 (Japanese).
[48]  H. Imamura, M. Matsubara, M. Minayoshi, et al., “A criterion for evaluation of obesity in men based on the relationship between percent body fat and medical examination parameters,” Japanese Journal of Physical Fitness and Sports Medicine, vol. 41, pp. 322–329, 1992 (Japanese).
[49]  K. Teshima, H. Imamura, K. Uchida, et al., “Relationship of simple predictors of obesity with coronary heart disease risk factors and nutrient intake in collegiate women,” Health Evaluation Promotion, vol. 31, pp. 463–468, 2004 (Japanese).
[50]  R. P. Donahue, T. J. Orchard, L. H. Kuller, and A. L. Drash, “Lipids and lipoproteins in a young adult population. The Beaver County Lipid Study,” American Journal of Epidemiology, vol. 122, no. 3, pp. 458–467, 1985.
[51]  J. M. Gaziano, J. E. Buring, J. L. Breslow et al., “Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction,” The New England Journal of Medicine, vol. 329, no. 25, pp. 1829–1834, 1993.
[52]  M. Russell, M. L. Cooper, M. R. Frone, and J. W. Welte, “Alcohol drinking patterns and blood pressure,” American Journal of Public Health, vol. 81, no. 4, pp. 452–457, 1991.
[53]  P. T. Williams, K. M. Vranizan, M. A. Austin, and R. M. Krauss, “Associations of age, adiposity, alcohol intake, menstrual status, and estrogen therapy with high-density lipoprotein subclasses,” Arteriosclerosis and Thrombosis, vol. 13, no. 11, pp. 1654–1661, 1993.
[54]  C. Nishimura, H. Imamura, K. Uchida, et al., “The relationship of alcohol intake to blood pressure and serum lipids and lipoprotein in men,” Japanese Journal of Multiphasic Health Testing and Services, vol. 26, pp. 144–149, 1999 (Japanese).
[55]  C. Nishimura, H. Imamura, Y. Masuda, et al., “The relationship of alcohol intake to blood pressure and serum lipids and lipoprotein in women,” Japanese Journal of Multiphasic Health Testing and Services, vol. 27, pp. 260–264, 2000 (Japanese).
[56]  P. T. Williams, “Interactive effects of exercise, alcohol, and vegetarian diet on coronary artery disease risk factors in 9242 runners: The National Runners' Health Study,” American Journal of Clinical Nutrition, vol. 66, no. 5, pp. 1197–1206, 1997.
[57]  S. R. Choudhury, H. Ueshima, Y. Kita et al., “Alcohol intake and serum lipids in a Japanese population,” International Journal of Epidemiology, vol. 23, no. 5, pp. 940–947, 1994.
[58]  R. D. Langer, M. H. Criqui, and D. M. Reed, “Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease,” Circulation, vol. 85, no. 3, pp. 910–915, 1992.
[59]  P. O. Attman, O. Samuelsson, and P. Alaupovic, “Diagnosis and classification of dyslipidemia in renal disease,” Blood Purification, vol. 14, no. 1, pp. 49–57, 1996.
[60]  D. C. Wheeler, “Abnormalities of lipoprotein metabolism in CAPD patients,” Kidney International, vol. 50, supplement 56, pp. S41–S46, 1996.
[61]  K. Saku, J. Sasaki, S. Naito, and K. Arakawa, “Lipoprotein and apolipoprotein losses during continuous ambulatory peritoneal dialysis,” Nephron, vol. 51, no. 2, pp. 220–224, 1989.
[62]  A. Kandoussi, C. Cachera, R. Reade, D. Pagniez, J. C. Fruchart, and A. Tacquet, “Apo AIV in plasma and dialysate fluid of CAPD patients: comparison with other apolipoproteins,” Nephrology Dialysis Transplantation, vol. 7, no. 10, pp. 1026–1029, 1992.
[63]  G. Franceschini, P. Maderna, and C. R. Sirtori, “Reverse cholesterol transport: physiology and pharmacology,” Atherosclerosis, vol. 88, no. 2-3, pp. 99–107, 1991.
[64]  P. D. Wood and W. L. Haskell, “The effect of exercise on plasma high density lipoproteins,” Lipids, vol. 14, no. 4, pp. 417–427, 1979.
[65]  C. Nishimura, H. Imamura, Y. Komatsu, et al., “Physical fitness, blood properties, and nutritional intake of female college soccer players,” Journal of Exercise Sports Physiology, vol. 2, pp. 159–166, 1995 (Japanese).
[66]  E. Suter and M. R. Hawes, “Relationship of physical activity, body fat, diet, and blood lipid profile in youths 10-15 yr,” Medicine and Science in Sports and Exercise, vol. 25, no. 6, pp. 748–754, 1993.
[67]  J. Skoumas, C. Pitsavos, D. B. Panagiotakos et al., “Physical activity, high density lipoprotein cholesterol and other lipids levels, in men and women from the ATTICA study,” Lipids in Health and Disease, vol. 2, article 1, 2003.
[68]  S. Kodama, S. Tanaka, K. Saito et al., “Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis,” Archives of Internal Medicine, vol. 167, no. 10, pp. 999–1008, 2007.
[69]  J. L. Durstine, P. W. Grandjean, P. G. Davis, M. A. Ferguson, N. L. Alderson, and K. D. DuBose, “Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis,” Sports Medicine, vol. 31, no. 15, pp. 1033–1062, 2001.
[70]  H. Yoshida, T. Ishikawa, M. Suto et al., “Effects of supervised aerobic exercise training on serum adiponectin and parameters of lipid and glucose metabolism in subjects with moderate dyslipidemia,” Journal of Atherosclerosis and Thrombosis, vol. 17, no. 11, pp. 1160–1166, 2010.
[71]  M. A. Kantor, E. M. Cullinane, P. N. Herbert, and P. D. Thompson, “Acute increase in lipoprotein lipase following prolonged exercise,” Metabolism, vol. 33, no. 5, pp. 454–457, 1984.
[72]  E. Ritz, J. Augustin, J. Bommer, et al., “Should hyperlipemia of renal failure be treated?” Kidney International, vol. 28, no. 17, supplement, pp. S-84–S-87, 1985.
[73]  A. C. Goldberg and G. Schonfeld, “Effects of diet on lipoprotein metabolism,” Annual Review of Nutrition, vol. 5, pp. 195–212, 1985.
[74]  P. Painter and S. W. Zimmerman, “Exercise in end-stage renal disease,” American Journal of Kidney Diseases, vol. 7, no. 5, pp. 386–394, 1986.

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