All Title Author
Keywords Abstract


Platelet Indices in Patients with Acute Coronary Syndrome

DOI: 10.4236/jbm.2015.311009, PP. 71-76

Keywords: Platelets, Platelet Indices, Acute Coronary Syndrome, CK-MB

Full-Text   Cite this paper   Add to My Lib

Abstract:

The platelet indices Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Plate-letcrit (PCT) provided by automated hematology analysis are rarely used in clinical practice. Platelets play a central role in the pathogenesis of acute coronary syndromes (ACS) and high MPV has been associated to more reactive platelets and regarded as an independent risk factor for myocardial infarction. In this study, platelet indices were evaluated in 39 patients with ACS presenting two altered biochemical parameters, C reactive protein (CRP) and creatine kinase fraction MB (CK-MB). The results obtained showed significantly higher MPV and PDW values in the group with ACS in comparison to the control group. Also observed was a weak but significant positive correlation between MPV and CK-MB. In view of findings of previous studies, which have associated macroplatelets with higher thrombotic potential our results suggest that the use of the MPV and PDW indices as additional and complementary markers may contribute to the investigation and follow-up of thrombotic risk in patients with ACS.

References

[1]  Venturinelli, M.L., Hovnan, A., Soeiro, A.M., Nicolau, J.C., Ramires, J.A.F.; D’Amico, E.A. and Serrano Júnior, C.V. (2006) Ativacao plaquetária em formas clínicas distintas da doenca arterial coronariana (papel da P-selectina e de outros marcadores nas anginas estável e instável. Arquivos Brasileiros de Cardiologia, 87, 446-450.
http://dx.doi.org/10.1590/S0066-782X2006001700008
[2]  Khode, V., Sindhur, J., Kanbur, D., Ruikar, K. and Nallulwar, S. (2012) Mean Platelet Volume and Other Platelet Volume Indices in Patients with Stable Coronary Artery Disease and Acute Myocardial Infarction: A Case Control Study. Journal of Cardiovascular Disease Research, 3, 272-275.
http://dx.doi.org/10.4103/0975-3583.102694
[3]  Endler, G., Klimesch, A., Sunder-Plassmann, H., Schillinger, M., Exner, M. and Mannhalter, C. (2002) Mean Platelet Volume Is an Independent Risk Factor for Myocardial Infarction but Not for Coronary Artery Disease. British Journal of Haematology, 117, 399-404.
http://dx.doi.org/10.1046/j.1365-2141.2002.03441.x
[4]  Wendland, A.E., Farias, M.G. and Manfroi, W.C. (2009) Volume plaquetário médio e doenca cardiovascular. Jornal Brasileiro de Patologia e Medicina Laboratorial, 45, 371-378.
http://dx.doi.org/10.1590/S1676-24442009000500005
[5]  Greisenegger, S., Endler, G., Hisieh, K., Tentschert, S., Mannhalter, C. and Lalouscheck, W. (2004) Is Elevated Mean Platelet Volume Associated with a Worse Outcome in Patients with Acute Ischemic Cerebrovascular Events? Stroke, 35, 1688-1691.
http://dx.doi.org/10.1161/01.STR.0000130512.81212.a2
[6]  Lippi, G., Filippozzi, L., Salvagno, G.L., Montagnana, M., Franchini, M. and Guidi, G.C. (2009) Increased Mean Platelet Volume in Patients with Acute Coronary Syndromes. Archives of Pathology & Laboratory Medicine, 133, 1441-1443.
[7]  Farias, M. and Bó, S.D. (2008) Determinacao do intervalo de referência para o volume plaquetário médio (VPM) utilizando o analisador hematológico Pentra 120 ABX. RBAC, 40, 39-41.
[8]  Jurcut, C., Caraiola, S., Nitescu, D., Mihai, C., Baicus, A., Predeteanu, D., Ginghina, C. and Tanasescu, C. (2010) Platelet Histogram Indices and Cardiovascular Disease in Patients with Rheumatoid Arthritis. Romanian Journal of Internal Medicine, 48, 51-55.
[9]  Yang, A., Pizulli, L. and Lüderitz, B. (2006) Mean Platelet Volume as Marker of Restenosis after Percutaneous Transluminal Coronary Angioplasty in Patients with Stable and Unstable Angina Pectoris. Thrombosis Research, 117, 371-377.
http://dx.doi.org/10.1016/j.thromres.2005.04.004
[10]  Yilmaz, M.B., Cihan, G., Guray, Y., Guray, U., Kisacik, H.L. and Sasmaz, H. (2008) Role of Mean Platelet Volume in Triaging Acute Coronary Syndromes. Journal of Thrombosis and Thrombolysis, 26, 49-54.
http://dx.doi.org/10.1007/s11239-007-0078-9
[11]  Chu, H., Chen, W.-L., Huang, C.-C., Chang, H.-Y., Kuo, H.-Y., Gau, C.-M., Chang, Y.-C. and Shen, Y.-S. (2011) Diagnostic performance of mean platelet volume for patients with acute coronary syndrome visiting an emergency department with acute chest pain: the Chinese scenario. Emergency Medicine Journal, 28, 569-574.
http://dx.doi.org/10.1136/emj.2010.093096
[12]  Guthikonda, S., Alviar, C.L. and Vaduganathan, M. (2008) Role of Reticulated Platelets and Platelet Size Heterogeneity on Platelet Activity after Dual Antiplatelet Therapy with Aspirin and Clopidogrel in Patients with Stable Coronary Artery Disease. Journal of the American College of Cardiology, 52, 743-749.
http://dx.doi.org/10.1016/j.jacc.2008.05.031
[13]  Grove, E.L. (2012) Antiplatelet Effect of Aspirin in Patients with Coronary Artery Disease. Danish Medical Journal, 59, B4506.
[14]  De Luca, G., Secco, G.G., Iorio, S., Verdoia, M., Bellomo, G. and Marino, P. (2012) Short-Term Effects of Aspirin and Clopidogrel on Mean Platelet Volume among Patients with Acute Coronary Syndromes. A Single-Center Prospective Study. Blood Coagulation & Fibrinolysis, 23, 756-759.
http://dx.doi.org/10.1097/MBC.0b013e328358e941
[15]  Vassiladis, E., Barascuk, N., Didangelos, A. and Karsdal, M.A. (2012) Novel Cardiac-Specific Biomarkers and the Cardiovascular Continuum. Biomark Insights, 7, 45-57.
http://dx.doi.org/10.4137/BMI.S9536
[16]  Alexander, J.H., Sparapani, R.A., Mahaffey, K.W., Deckers, J.W., Newby, L.K., Ohman, E.M., Corbalán, R., Chierchia, S.L., Boland, J.B., Simoons, M.L., Califf, R.M., Topol, E.J. and Harrington, R.A. (2000) Association between Minor Elevations of Creatine Kinase-MB Level and Mortality in Patients with Acute Coronary Syndromes without ST-Segment Elevation. JAMA, 283, 347-353.
http://dx.doi.org/10.1001/jama.283.3.347
[17]  Capellan, O., Hollander, J.E. and Pollack Jr., C. (2003) Prospective Evaluation of Emergency Department Patients with Potential Coronary Syndromes Using Initial Absolute CK-MB vs. CK-MB Relative Index. Journal of Emergency Medicine, 24, 361-367.
http://dx.doi.org/10.1016/S0736-4679(03)00030-1
[18]  Osuna, P.P., Ballesteros, F., Munoz, J.L., Fernández, P.L., Jiménez, A., Domínguez, M. and Luengo, C. (1998) Influencia del volumen plaquetario médio sobre el pronostico a corto plazo del infarto agudo de miocárdio. Revista Espanola de Cardiología, 51, 816-822.
http://dx.doi.org/10.1016/S0300-8932(98)74825-0
[19]  Schultheiss, H.P., Tschoepe, D., Esser, J., Schwippert, B., Roesen, P., Nieuwenhuis, H.K., Schmidt-Soltau, C. and Strauer, B. (1994) Large Platelets Continue to Circulate in an Activated State after Myocardial Infarction. European Journal of Clinical Investigation, 24, 243-247.
http://dx.doi.org/10.1111/j.1365-2362.1994.tb01081.x

Full-Text

comments powered by Disqus