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Carbohydrate-Derived Organocatalysts for the Reduction of Imines with Trichlorosilane

DOI: 10.4236/msce.2015.36008, PP. 48-53

Keywords: Carbohydrate, Organocatalyst, Reduction, Imine

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Abstract:

The backbone of D-glucosamine hydrochloride was fine-tuned and modified by protecting the hydroxyl groups. In order to reduce imines with trichlorosilane, the carbohydrate-derived organocatalysts were prepared and screened. Methyl-4,6-O-benzylidene-2-amino-2-deoxy-α-D-glucopyr anoside was found as the best catalyst. The reduction was proceeded under CHCl3 as solvent at 40?C, affording 68% - 94% yield.

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