This paper explores the historical narrations of AIDS in Indonesia that shape its construction. It will focus on the relation between Governmental and Islamic responses to HIV/AIDS. In this research, we will focus on the governmental official commission on AIDS prevention (KPA) which is concern about HIV and AIDS and MUI as a government Islamic institution. This paper will argued that the responses of both parties in the Indonesian “narrations” of HIV/AIDS can influence the practice of AIDS prevention. Government ways to treat AIDS in Indonesia have changed overtime in line with the development of medical and social work efforts to cope with the problem of HIV/AIDS. However the Islamic institution response in Indonesia does not change anymore and seems not to have seriously attention in the issue of HIV/AIDS, it can be look from the unchanging MUI’s fatwa which is limited the problem of AIDS solely as morality problem.