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新生儿先天性凝血因子VII缺乏一例报道
Neonatal Congenital Absence of Clotting Factor VII: A Case Report

DOI: 10.12677/ACRP.2015.31001, PP. 1-3

Keywords: 新生儿,先天性凝血因子VII缺乏,新生儿出血症
Newborn
, Coagulation Factor VII, Hemorrhagic Disease of Newborn

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Abstract:

目的:探讨新生儿先天性凝血因子VII缺乏的原因和治疗方法。方法:对我科发现的1例新生儿先天性凝血因子VII缺乏病例进行临床资料的回顾性分析。结果:患儿因无明显原因及诱因发现皮肤出血点,转入新生儿重症监护室,经送检凝血因子VII:C 0.5%,提示凝血因子VII缺乏症,送检其父母、姐姐的凝血因子VII C分别为:28.5%、31.0%、和25.2%,提示与遗传因素有关。经反复输注凝血酶原复合物、新鲜冰冻血浆等治疗后,康复出院。结论:在临床工作中,新生儿存在凝血功能异常,治疗效果不满意,应及时完善凝血因子检查,以避免漏诊、误诊,延误病情。
Objective: To investigate the causes and treatment of congenital absence of clotting factor VII. Me-thod: The clinical data of one infant with the disease of congenital absence of clotting factor VII in our department were retrospectively analyzed. Result: The infant was transferred to neonatal ICU because of the skin bleeding for no apparent reason. The determination of coagulation factor VII was C 0.5%, revealing the coagulation factor VII deficiency. The coagulation factor VII C of the in-fant’s parents and sister was respectively 28.5%, 31.0% and 25.2%, indicating the relationship with genetic factors. After repeated infusion of fresh frozen plasma and prothrombin complex, the infant recovered and was discharged from hospital. Conclusion: In clinical work, coagulant function abnormality of neonatal repeatedly, we should check the clotting factor as soon as possible in order to avoid missed diagnosis, misdiagnosis and delay treatment.

References

[1]  涂传清, 吴建曾, 李建辉, 张勤, 黄绵清 (2006) 一个遗传性凝血因子Ⅶ缺乏症家系研究及文献复习. 临床血液学杂志, 6, 348-349.
[2]  洪国, 连云宗, 李极品 (2008) 凝血因子VIIC329G突变导致遗传性凝血因子VII缺乏症. 中国实验诊断学, 11, 1358-1360.
[3]  丁秋兰, 王鸿利, 王学锋, 王明山 (2003) 遗传性凝血因子VII缺陷症家系基因型与临床表型的关系. 临床血液学杂志, 9, 220-224.
[4]  胡亚美, 江载芳 (2002) 诸福棠实用儿科学. 第7版, 人民卫生出版社, 北京, 1816-1817.

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