背景：真菌以不同方式和程度累及脑组织、脑膜和颅内血管，其中颅内真菌性肉芽肿(intracranial fungal granuloma, IFG)并不常见，但死亡率高(50%~63%)。国内IFG文献多见于成人病例的个案报道，少见儿童报道。方法：11岁大女性患儿1例，因“反复右枕部疼痛3个月，加重伴呕吐半月”入院，入院查体无异常，MRI提示颅内占位性病变，遂给予手术处理，术后诊断颅内真菌性肉芽肿，并给予术后抗真菌治疗及护理。结果：术后患儿头痛症状消失，至本文投送之日，患儿无临床症状再次出现。结论：手术联合抗真菌治疗IFG仍应作为目前首选治疗方案。
Background: Fungi can intrude into brain, meninges and intracranial blood vessels in different ways, causing several diseases including intracranial fungal granuloma (IFG), which is not common but has a high mortality rate (50% - 63%). Domestic literature about IFG is mostly reported in adult population other than children population. Methods: A 11 year-old female was admitted to the inpatient apartment of pediatrics. The patient showed repeated right occiput pain for more than 3 months, aggravated with vomiting for 15 days. Physical examination on admission revealed no abnormalities. MRI revealed intracranial space-occupying lesions. Then we gave her surgical treatment. The postoperative diagnosis was intracranial fungal granuloma, so that we gave her the antifungal treatment and nursing. Results: The patient showed no more headache ever since the surgery. Until the date of sending out this paper, the patient showed no abnormal clinical manifestations. Conclusion: At present, surgery combined with antifungal therapy should still be considered as the ultimate choice of IFG treatment.
A. A. Siddiqui, A. A. Shah and S. H. Bashir. Craniocerebrala- spergillosis of sinonasal origin in immu-nocompetent patients: Clinical spectrum and outcome in 25 cases. Neurosurgery, 2004, 55(3): 602-613.