Recsod? has been used for treating epilepsy and ophthalmological disease. Oxidative stress has been demonstrated to be a pathogenic chain of these diseases. Parameters of pro- and antioxidant systems were studied in all the patients treated. Recsod? drug was shown to produce positive effect in all the patients. Improvement of patients’ clinical condition correlated with an increase in antioxidant activities. Antioxidants, in particular, the recombinant human SOD drug, proved to be effective in treatment of some neurological and ophthalmological diseases.
Gutteridge, J.M.C. and Halliwell, B. (2000) Free Radicals and Antioxidants in the Year 2000. Annals of the New York Academy of Sciences, 899, 136-147. http://dx.doi.org/10.1111/j.1749-6632.2000.tb06182.x
Halliwell, B. (1992) Reactive Oxygen Species and the Central Nervous System. In: Packer, L., Philipko, L. and Christen, Y., Eds., Free Radical in the Brain. Aging, Neurological and Mental Disorders. Springer-Verlag, Berlin, 21-40.
Levadnaya, O.V., Dontchenko, G.V., Valutsina, V.M., et al. (1998) The Ratio between Values of Activity of the Antioxidant System in Various Tissues of Intact Animals. Ukrainian Biochemical Journal, 70, 53-58.
Beatty, S., Koh, H., Phil, M., Henson, D. and Boulton, M. (2000) The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration. Survey of Ophthalmology, 45, 115-134.
Freitas, R. (2009) Investigation of Oxidative Stress Involvement in Hippocampus in Epilepsy Model Induced by Pilocarpine. Neuroscience Letters, 462, 225-229. http://dx.doi.org/10.1016/j.neulet.2009.07.037
Chang, S.J. and Yu, B.C. (2010) Mitochondrial Matters of the Brain: Mitochondrial Dysfunction and Oxidative Status in Epilepsy. Journal of Bioenergetics and Biomembranes, 42, 457-459. http://dx.doi.org/10.1007/s10863-010-9317-4
Gavrilov, V.B., Gavrilov, A.R. and Mazhul, L.M. (1987) Analysis of Methods of Determining Products of Lipid Peroxidation in Serum Test with Thiobarbituric Acid. The Issues of Medical Chemistry, 33, 118-122.
Kostyuk, V.A., Potapovitch, A.I. and Kovaleva, Z.V. (1990) Simple and Sensitive Method for Determining the Activity of Superoxide Dismutase, Based on the Oxidation Reaction of Quercetin. The Issues of Medical Chemistry, 36, 88-91.
Prashar, S., Pandav, S.S., Gupta, A. and Nath, R. (1993) Antioxidant Enzymes in RBCs Biological Index of Age Related Macular Degeneration. Acta Ophthalmologica (Copenh), 71, 214-218.
Delcourt, C., Cristol, J.P., Tessier, F., Léger, C.L., Descomps, B. and Papoz, L. (1999) Age-Related Macular Degeneration and Antioxidant Status in the POLA Study. Archives of Ophthalmology, 117, 1384-1390.
Alekseev, V.N. and Usachev, V.V. (2003) Study of the Efficacy of the Drug Rexod in Patients with Primary Open-Angle Glaucoma. Saturday Papers Dedicated to the 90th Anniversary of Department, State Medical Academy of Them, Mechnikov, Glaucoma and Other Eye Diseases, SPb, 97-106.
Stefanov, A.V., Derimedved, L.V., Churilova, I.V., Drogovoz, S.M., Kutsenko, T.A. and Shchekina, E.G. (2004) Clinical and Experimental Substantiation of Application of Superoxide Dismutase in Medicine. Publishing House of Pau, Golden, p. 288.
Dubinina, E.E., Sofronova, L.N., Litvinenko, L.A. and Muschkatina, O.F. (1991) Diagnostic Value of Determines the State of the Antioxidant System in Retinopathy of Prematurity. Issues of Protection of Motherhood and Childhood, 36, 30-34.
Ben-Menachem, E., Kyllerman, M. and Marklund, S. (2000) Superoxide Dismutase and Glutathione Peroxidase Function in Progressive Myoclonus Epilepsies. Epilepsy Research, 40, 33-39. http://dx.doi.org/10.1016/S0920-1211(00)00096-6
Chen, D., Lu, Y., Yu, W., Luo, J., Xiao, Z., Xiao, F. and Wang, X. (2012) Clinical Value of Decreased Superoxide Dismutase 1 in Patients with Epilepsy. Seizure: European Journal of Epilepsy, 21, 508-511.