between Nigerian Bonny Light crude oil (NBLCO) induced
hypoglycaemia and endogenous serum insulin concentration; the role of
antioxidant vitamin C or E supplementation was the focus of this study. Forty
adult male Wistar rats were randomly divided into group I, which served as the
control, group II, which was oral gavaged 6 ml/kg of NBLCO, groups III and IV, which
were in addition to 6 ml/kg of NBLCO supplemented with 9 ml/kg and 1 mg/kg of
vitamin E or C, respectively for 28 days. Results showed that NBLCO
significantly (p < 0.05) lower
body weight and food intake compared with control. These effects exerted by
NBLCO were however significantly (p <
0.05) reversed by vitamin E or C supplementation. The NBLCO significantly (p < 0.05) reduced fasting blood
glucose (FBG) when compared with control, the antioxidant vitamins supplementation
significantly (p < 0.05) reversed
the crude oil effect. The mean serum insulin level in NBLCO, vitamin E or C
supplemented groups is not significantly different from the control. There was
no significant correlation between FBG and fasting serum insulin concentrations
in all the groups on day 28. It has been demonstrated in this study that direct
oral ingestion of crude oil (NBLCO) could reduce food intake, body weight and
cause hypoglycemia; the hypoglycemia may not be a function of serum insulin
concentration. Interestingly, the hazardous effects of NBLCO could be
ameliorated with antioxidant vitamin C or E supplementation.
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