Twelve new triazole derivatives of Phrymarolin were prepared from Phrymarolin I and the structures of all the derivatives were fully characterized by 1H-NMR, 13C-NMR and MS spectral data analyses. Larvicidal activities against 4rd instar larvae of Culex pipiens pallens of these Phrymarolin analogues were assayed. Although the triazole derivatives of Phrymarolin showed certain larvicidal activity, they showed lower activity than Phrymarolin I. The typical non-natural groups triazole substituents reduced the larvicidal activity of Phrymarolin derivatives.
Park, I.K.; Shin, S.C.; Kim, C.S.; Lee, H.J.; Choi, W.S.; Ahn, Y.J. Larvicidal activity of lignans identified in Phryma leptostachya Var. asiatica roots against three mosquito species. J. Agric. Food Chem 2005, 53, 969–972.
Seo, S.M.; Park, I.K. Larvicidal activity of medicinal plant extracts and lignan identified in Phryma leptostachya var. asiatica roots against housefly (Musca domestica L.). Parasitol. Res 2012, 110, 1849–1853.