Esomeprazole is the S-isomer of Omeprazole and it is
a proton pump inhibitor (PPI). Esomeprazole is used in acid-related disorders
and it is available as several brands in the market which makes it difficult
for doctors to select the effective, safe and economic one for patients.
Therefore we have decided to establish pharmaceutical equivalence among the
different brands of esomeprazole available in Karachi, Pakistan. In our present
study different brands of esomeprazole are evaluated for weight variation,
hardness and dissolution. Disintegration Test shows results for NEX 01, ESS 02,
EZI 03 and they disintegrate in 1.35, 1.15 and 2.15 minutes respectively. Dissolution
test demonstrate the result as NEX 01, ESS 02, EZI 03 is 100.00% for NEX,
117.87% for ESS and 80.66%. The results showed that all parameters
weight-variation, hardness, dissolution of different brands of esomeprazole are
in accordance with the USP limits.
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Huma, D. and Safila, N. (2014) Manufacturing of New Formulations of Isosorbide Mononitrate by Dry Granulation Method and Their Comparative Evaluation with Brands Available in the Market. International Research Journal of Pharmacy, 5, 168-171.
Naveed, S., Naseem, Y., Samie, S., Khan, S. and Ramzan, S. (2014) Degradation Study of Five Different Brands of Ciprofloxacin Using UV-Visible Spectrophotometer and Their Comparative Study. International Research Journal of Pharmacy, 5, 189-190. http://www.irjponline.com/admin/php/uploads/2130_pdf.pdf
Naveed, S. and Qamar, F. (2014) Comparative Study of Different Brands of Alprazolam. Global Journal of Medical Research, 14, 25-28. https://globaljournals.org/GJMR_Volume14/5-Comparative-Study-of-Different-Brands.pdf
Naveed, S. and Waheed, N. (2014) Comparative Study of Three Different Brands of Doxycycline Capsules Available in Karachi. Open Access Library Journal, 1, 1-7. http://dx.doi.org/10.4236/oalib.1100458 http://www.oalib.com/paper/3052751#.U5GpAXKSytk