Central East Antarctica ice cores preserve stratigraphic records of mineral dust originating from remote sources in the Southern Hemisphere, and represent useful indicators of climatic variations on glacial-interglacial time scales. The peripheries of the East Antarctic Ice Sheet, where ice-free areas with the potential to emit dust exist, have been less explored from this point of view. Here we present a new profile of dust deposition flux and grain size distributions from an ice core drilled at Talos Dome (Northern Victoria Land, East Antarctica), where there is a significant input of dust from proximal Antarctic ice-free areas. We analyze dust and stable water isotopes variations from the Last Glacial Maximum to the Late Holocene, and compare them to the EPICA Dome C profiles from Central East Antarctica. The smaller glacial-interglacial variations at Talos Dome compared to Dome C, and a distinctive decreasing trend during the Holocene, characterize the TALDICE dust profile. By deciphering the composite dust signal from both remote and local sources, we show the potential of this combined proxy of source activity and atmospheric transport to give information on both regional and larger spatial scales. In particular, we show how a regional signal, which we related to the deglaciation history of the Ross Sea embayment, can be superimposed to the broader scale glacial-interglacial variability that characterizes other Antarctic sites.