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PHARMACOLOGICAL SCREENING OF AYURVEDIC ANTIHYPERLIPIDEMIC FORMULATION: AN AYURVEDIC APPROACH

Keywords: Antilipidemic action , Ayurveda , Capparis decidua , Ziipus jujube , Ricinus communis.

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Abstract:

Doctrines of Ayurveda have momentous value even in the life of present day human life. These principles are based on the extraordinary observations and experimentations at various levels. Hence one cannot easily deny the observations put forward by the philosophers. According to one of its great preceptors Charaka- the dictum of Ayurveda is to maintain health of healthy people and to alleviate disorders in the diseased persons. The references of medicinal uses of herbs are recorded in Rgveda and Atharvaveda. Nighantus, the well-known compilations- are the very rich sources of herbal drug data ranging from identification, collection to therapeutics uses of the drugs.Since previous two decades there has been an increasing status emphasized on screening of herbs for hypolipidemic actions in order to reduce the risk of heart and other related disease. The high expenses and side effects of hyperlipidemia medications have led many populaces to search for alternate treatments. Only a few studies have been conducted to evaluate the effect of herbs mentioned in Ayurvedic texts on hyperlipidemia. Capparis Deciduas F., Ricinus Communis L., and Zizyphus Jujuba L. are traditionally used as antihyperlipidemic drugs as per Ayurvedic literature. Hence the present study was undertaken to investigate the antihyperlipidemic effect of a polyherbal formulation, prepared using the above three medicinal plants against Triton WR-1339 and High fat diet induced hyperlipidemia in rats. The probable mechanism of action of the extract may be inhibition of HMG-CoA reductase enzyme pathway.

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