Joint operation of flood control and hydropower generation for the Three Gorges cascade and Qingjiang cascade reservoirs in China was studied in this paper. The flood control and hydropower generation models were established for individual and joint operation of the cascade reservoirs. The models have considered reservoir flood prevention storage and electric compensation benefits among cascade reservoirs and were solved by the progressive optimality algorithms. Four typical years of 1954, 1981, 1982 and 1998 of the Yichang hydrological stations were selected to derive the design flood hydrographs. The results show that the average of Jingjiang River flood control standards can be raised to and 150-year and 168-year return periods respectively. The daily inflow data of consecutive hydrological years of 1982 - 1987 were used to test the models. Compared with the design operation rules, the joint operation of the multi-reservoir system can generate 5.992 billion kWh of extra power annual or an increase of 5.37% by the objective function of maximum hydropower generation. Through reservoir storage compensation, the spilled water of the Three Gorges and Qingjiang cascade reservoirs was decreased by 57.741 and 5.384 billion m3, respectively.