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Keywords Abstract

Molecular Dynamics Insight into the Interaction Mechanism of Inhibitor PMI with MDMX

DOI: 10.12677/hjcb.2012.23003, PP. 27-33

Keywords: p53-MDMX相互作用;分子动力学;MM-PBSA;结合自由能
p53-MDMX Interaction
, Molecular Dynamics, MM-PBSA, Binding Free Energy

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Restoration of p53 function is considered to be a new therapeutic strategy for anti-cancers. Molecular Dynamics (MD) simulations coupled with Molecular


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